OR8B2

Summary

OR8B2 (olfactory receptor family 8 subfamily B member 2, HGNC:8471) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 8B2 (Q96RD0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26595 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 96 total
• MANE Select transcript: NM_001005468

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8471
Approved symbol	OR8B2
Name	olfactory receptor family 8 subfamily B member 2
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000284680
Ensembl biotype	protein_coding
Entrez	26595

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641451

RefSeq mRNA: 1 — MANE Select: NM_001005468 NM_001005468

CCDS: CCDS31708

Canonical transcript exons

ENST00000641451 — 2 exons

Exon	Start	End
ENSE00003813023	124382394	124383360
ENSE00003813829	124384374	124384499

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 75.38.

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.38	silver quality
left testis	UBERON:0004533	46.48	gold quality
testis	UBERON:0000473	45.55	gold quality
right testis	UBERON:0004534	45.49	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
sperm	CL:0000019	42.39	silver quality
vastus lateralis	UBERON:0001379	41.41	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	40.27	gold quality
jejunum	UBERON:0002115	40.18	gold quality
cartilage tissue	UBERON:0002418	40.06	gold quality
oviduct epithelium	UBERON:0004804	40.03	gold quality
mammary duct	UBERON:0001765	39.98	gold quality
mucosa of sigmoid colon	UBERON:0004993	39.95	gold quality
deltoid	UBERON:0001476	39.83	gold quality
saphenous vein	UBERON:0007318	39.83	gold quality
parotid gland	UBERON:0001831	39.81	gold quality
oocyte	CL:0000023	39.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8b3b	ENSMUSG00000046150
mus_musculus	Or8b3	ENSMUSG00000049098
rattus_norvegicus	Or8b3	ENSRNOG00000062775
rattus_norvegicus	Or8b3c	ENSRNOG00000068253

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 8B2 — Q96RD0 (reviewed: Q96RD0)

Alternative names: Olfactory receptor OR11-309

All UniProt accessions (2): Q96RD0, A0A126GVQ4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005468* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96RD0-F1	89.41	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

76 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8B2	NCOA6	Q14686	368
OR8B2	NOVA1	P51513	326
OR8B2	OR51Q1	Q8NH59	263
OR8B2	ADPRS	Q9NX46	220
OR8B2	KCNF1	Q9H3M0	201
OR8B2	RPS4Y1	P22090	197
OR8B2	LHX5	Q9H2C1	196
OR8B2	FEZF1	A0PJY2	185
OR8B2	KCNG1	Q9UIX4	181
OR8B2	PTPN5	P54829	169
OR8B2	HOMER3	Q9NSC5	165
OR8B2	HEMGN	Q9BXL5	164
OR8B2	NNAT	Q16517	162
OR8B2	OR52D1	Q9H346	160
OR8B2	ELP5	Q8TE02	155

IntAct

0 interactions, top by confidence:

BioGRID (1): ZNF24 (Co-fractionation)

ESM2 similar proteins: A6NCV1, A6NF89, A6NJZ3, A6NL08, A6NM76, O95221, P0C7N1, P0C7N5, P37070, P37071, P37072, Q15617, Q60886, Q6IEU7, Q8N127, Q8NGE1, Q8NGG0, Q8NGG8, Q8NGP8, Q8NGP9, Q8NGR8, Q8NGS9, Q8NGT0, Q8NGT1, Q8NGX3, Q8NH01, Q8NH10, Q8NH51, Q8NH69, Q8VEW5, Q8VF65, Q8VF66, Q8VF76, Q8VFD0, Q8VFD3, Q8VFK2, Q8VG02, Q8VG03, Q8VG04, Q8VG07

Diamond homologs: A6NDH6, A6NET4, A6NHG9, A6NKK0, A6NL26, A6NMS3, O95221, P0C626, P0C628, P0C7N1, P0C7N5, P0DMU2, P0DN80, P34985, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60884, Q60886, Q60893, Q60894, Q6UXT6, Q7TS48, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

96 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	9
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

245 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124382587:C:T	acceptor_gain	0.8500
11:124382587:C:CT	acceptor_gain	0.8300
11:124383022:C:CT	acceptor_gain	0.7700
11:124382588:A:T	acceptor_gain	0.7000
11:124382475:C:CC	acceptor_gain	0.6900
11:124382471:CAAA:C	acceptor_gain	0.6500
11:124382504:CACAT:C	acceptor_gain	0.6400
11:124382673:C:CC	acceptor_gain	0.6200
11:124383225:A:AC	donor_gain	0.6000
11:124383226:C:CC	donor_gain	0.6000
11:124382511:G:GC	acceptor_gain	0.5900
11:124383221:GCCTA:G	donor_loss	0.5900
11:124383222:CCTA:C	donor_loss	0.5900
11:124383223:CTA:C	donor_loss	0.5900
11:124383224:TACCA:T	donor_loss	0.5900
11:124383225:ACCA:A	donor_loss	0.5900
11:124383023:G:T	acceptor_gain	0.5800
11:124382551:C:CT	acceptor_gain	0.5600
11:124383226:CCATG:C	donor_gain	0.5600
11:124383111:G:GC	acceptor_gain	0.5500
11:124382670:ATGCT:A	acceptor_loss	0.5400
11:124382671:TG:T	acceptor_gain	0.5400
11:124382671:TGCT:T	acceptor_loss	0.5400
11:124382672:GC:G	acceptor_loss	0.5400
11:124382673:C:CG	acceptor_loss	0.5400
11:124382674:T:G	acceptor_loss	0.5400
11:124382508:T:TC	acceptor_gain	0.5200
11:124383163:A:AC	donor_gain	0.5200
11:124383225:AC:A	donor_gain	0.5200
11:124383226:CC:C	donor_gain	0.5200

AlphaMissense

2072 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:124382840:G:C	F168L	0.812
11:124382840:G:T	F168L	0.812
11:124382842:A:G	F168L	0.812
11:124383308:A:C	F12L	0.801
11:124383308:A:T	F12L	0.801
11:124383310:A:G	F12L	0.801
11:124382630:G:C	F238L	0.707
11:124382630:G:T	F238L	0.707
11:124382632:A:G	F238L	0.707
11:124382711:A:C	S211R	0.681
11:124382711:A:T	S211R	0.681
11:124382713:T:G	S211R	0.681
11:124382588:A:C	F252L	0.677
11:124382588:A:T	F252L	0.677
11:124382590:A:G	F252L	0.677
11:124382591:A:C	F251L	0.653
11:124382591:A:T	F251L	0.653
11:124382593:A:G	F251L	0.653
11:124383251:A:C	F31L	0.611
11:124383251:A:T	F31L	0.611
11:124383253:A:G	F31L	0.611
11:124382573:G:C	F257L	0.601
11:124382573:G:T	F257L	0.601
11:124382575:A:G	F257L	0.601
11:124382636:T:A	K236N	0.594
11:124382636:T:G	K236N	0.594
11:124382516:G:C	F276L	0.586
11:124382516:G:T	F276L	0.586
11:124382518:A:G	F276L	0.586
11:124383038:A:C	F102L	0.585

dbSNP variants (sampled 300 via entrez): RS1000166192 (11:124397220 G>A,C), RS1000715058 (11:124389855 T>C), RS1000821067 (11:124382894 T>C), RS1000863538 (11:124389111 A>G), RS1000890054 (11:124384583 A>C), RS1001490222 (11:124394702 G>A), RS1001574328 (11:124386242 A>T), RS1001921269 (11:124383213 C>A,G,T), RS1002512997 (11:124393849 C>A), RS1002616536 (11:124394852 TTA>T), RS1003056885 (11:124399240 C>T), RS1003107428 (11:124386585 A>C), RS1003108702 (11:124393575 AC>A), RS1003801774 (11:124398098 C>G,T), RS1003827273 (11:124391098 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Cadmium	decreases expression	1
Endosulfan	decreases expression	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.