OR8B3

Summary

OR8B3 (olfactory receptor family 8 subfamily B member 3, HGNC:8472) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 8B3 (Q8NGG8). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390271 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• MANE Select transcript: NM_001005467

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8472
Approved symbol	OR8B3
Name	olfactory receptor family 8 subfamily B member 3
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000284609
Ensembl biotype	protein_coding
Entrez	390271

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641139

RefSeq mRNA: 1 — MANE Select: NM_001005467 NM_001005467

CCDS: CCDS31709

Canonical transcript exons

ENST00000641139 — 2 exons

Exon	Start	End
ENSE00003813970	124395534	124397368
ENSE00003814123	124398690	124399024

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 78.37.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.37	gold quality
colonic epithelium	UBERON:0000397	41.17	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.08	gold quality
muscle tissue	UBERON:0002385	33.36	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
prefrontal cortex	UBERON:0000451	31.76	silver quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
testis	UBERON:0000473	30.88	gold quality
placenta	UBERON:0001987	30.11	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
left testis	UBERON:0004533	29.72	silver quality
right testis	UBERON:0004534	29.01	silver quality
liver	UBERON:0002107	28.42	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.99	gold quality
primary visual cortex	UBERON:0002436	27.84	gold quality
monocyte	CL:0000576	27.83	gold quality
leukocyte	CL:0000738	27.80	gold quality
frontal cortex	UBERON:0001870	27.73	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality
superior frontal gyrus	UBERON:0002661	26.89	gold quality
blood	UBERON:0000178	26.60	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-CURD-11	no	19.29
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8b3b	ENSMUSG00000046150
mus_musculus	Or8b3	ENSMUSG00000049098
rattus_norvegicus	Or8b3	ENSRNOG00000062775
rattus_norvegicus	Or8b3c	ENSRNOG00000068253

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 8B3 — Q8NGG8 (reviewed: Q8NGG8)

Alternative names: Olfactory receptor OR11-311

All UniProt accessions (1): Q8NGG8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005467* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 2, sequence conflict 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGG8-F1	90.75	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

186 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8B3	SMIM19	Q96E16	528
OR8B3	MRPS5	P82675	435
OR8B3	ANKMY2	Q8IV38	398
OR8B3	TBC1D8B	Q0IIM8	397
OR8B3	WDR17	Q8IZU2	372
OR8B3	C10orf90	Q96M02	370
OR8B3	DENND5B	Q6ZUT9	367
OR8B3	NDC1	Q9BTX1	356
OR8B3	TBATA	Q96M53	353
OR8B3	EME2	A4GXA9	324
OR8B3	KIF12	Q96FN5	322
OR8B3	CPNE8	Q86YQ8	321
OR8B3	SRSF8	Q9BRL6	321
OR8B3	PHACTR4	Q8IZ21	320
OR8B3	NXNL1	Q96CM4	310

IntAct

0 interactions, top by confidence:

BioGRID (1): OR8B3 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A6NCV1, A6NF89, A6NJZ3, A6NL08, A6NM76, O95221, P0C7N1, P0C7N5, P37070, P37071, P37072, Q15617, Q60886, Q6IEU7, Q8N127, Q8NGE1, Q8NGG0, Q8NGG8, Q8NGP8, Q8NGP9, Q8NGR8, Q8NGS9, Q8NGT0, Q8NGT1, Q8NGX3, Q8NH01, Q8NH10, Q8NH51, Q8NH69, Q8VEW5, Q8VF65, Q8VF66, Q8VF76, Q8VFD0, Q8VFD3, Q8VFK2, Q8VG02, Q8VG03, Q8VG04, Q8VG07

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

226 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124396595:C:T	acceptor_gain	0.9100
11:124396595:C:CT	acceptor_gain	0.8600
11:124397030:C:CT	acceptor_gain	0.7800
11:124397031:A:T	acceptor_gain	0.7700
11:124396596:A:T	acceptor_gain	0.7600
11:124397018:A:C	acceptor_gain	0.7600
11:124397021:C:CT	acceptor_gain	0.7300
11:124396483:C:CC	acceptor_gain	0.7100
11:124397011:A:C	acceptor_gain	0.7100
11:124397026:A:C	acceptor_gain	0.7100
11:124397022:A:T	acceptor_gain	0.6600
11:124396479:CAAA:C	acceptor_gain	0.6500
11:124397007:CAACA:C	acceptor_gain	0.6100
11:124397233:A:AC	donor_gain	0.6100
11:124397234:C:CC	donor_gain	0.6100
11:124397008:A:T	acceptor_gain	0.5900
11:124397229:GCCTA:G	donor_loss	0.5900
11:124397230:CCTA:C	donor_loss	0.5900
11:124397231:CTAC:C	donor_loss	0.5900
11:124397232:TA:T	donor_loss	0.5900
11:124397233:A:AG	donor_loss	0.5900
11:124397234:C:A	donor_loss	0.5900
11:124396512:CACAT:C	acceptor_gain	0.5800
11:124397013:G:C	acceptor_gain	0.5800
11:124397026:A:AC	acceptor_gain	0.5700
11:124396681:C:CC	acceptor_gain	0.5500
11:124397234:CCATG:C	donor_gain	0.5500
11:124396519:G:GC	acceptor_gain	0.5400
11:124396559:C:CT	acceptor_gain	0.5300
11:124397171:A:AC	donor_gain	0.5300

AlphaMissense

2077 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:124397316:A:C	F12L	0.933
11:124397316:A:T	F12L	0.933
11:124397318:A:G	F12L	0.933
11:124396848:G:C	F168L	0.894
11:124396848:G:T	F168L	0.894
11:124396850:A:G	F168L	0.894
11:124396719:A:C	S211R	0.839
11:124396719:A:T	S211R	0.839
11:124396721:T:G	S211R	0.839
11:124396482:A:C	S290R	0.834
11:124396482:A:T	S290R	0.834
11:124396484:T:G	S290R	0.834
11:124397317:A:G	F12S	0.781
11:124396638:G:C	F238L	0.769
11:124396638:G:T	F238L	0.769
11:124396640:A:G	F238L	0.769
11:124396599:A:C	F251L	0.759
11:124396599:A:T	F251L	0.759
11:124396601:A:G	F251L	0.759
11:124396596:A:C	F252L	0.749
11:124396596:A:T	F252L	0.749
11:124396598:A:G	F252L	0.749
11:124396987:C:G	R122P	0.745
11:124396626:G:C	S242R	0.725
11:124396626:G:T	S242R	0.725
11:124396628:T:G	S242R	0.725
11:124396816:C:G	C179S	0.721
11:124396817:A:T	C179S	0.721
11:124397259:A:C	F31L	0.717
11:124397259:A:T	F31L	0.717

dbSNP variants (sampled 300 via entrez): RS1000010634 (11:124403984 G>A,T), RS1000084005 (11:124404175 T>G), RS1000166192 (11:124397220 G>A,C), RS1000362928 (11:124410129 C>T), RS1001231219 (11:124406667 C>G), RS1001313789 (11:124408278 G>C,T), RS1001405602 (11:124400760 A>T), RS1001534475 (11:124408720 T>C), RS1001702542 (11:124402007 T>G), RS1001922091 (11:124407341 A>C), RS1002034432 (11:124400638 G>A,C), RS1002269873 (11:124406985 G>A), RS1002560914 (11:124400833 T>C), RS1002949244 (11:124405515 A>G), RS1003056885 (11:124399240 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002945_15	Emphysema imaging phenotypes	2.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007626	emphysema imaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.