OR8G1

Summary

OR8G1 (olfactory receptor family 8 subfamily G member 1, HGNC:8484) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 8G1 (Q15617). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3’ end deletion.

Source: NCBI Gene 26494 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 29 total
• MANE Select transcript: NM_001002905

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8484
Approved symbol	OR8G1
Name	olfactory receptor family 8 subfamily G member 1
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Aliases	TPCR25, HSTPCR25
Ensembl gene	ENSG00000197849
Ensembl biotype	protein_coding
Entrez	26494

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641972

RefSeq mRNA: 1 — MANE Select: NM_001002905 NM_001002905

CCDS: CCDS73407

Canonical transcript exons

ENST00000641972 — 3 exons

Exon	Start	End
ENSE00003812828	124249660	124254364
ENSE00003812900	124247801	124247880
ENSE00003813723	124241095	124241364

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 69.17.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0138 / max 12.6304, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117358	0.0138	3

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	69.17	gold quality
secondary oocyte	CL:0000655	62.32	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	52.54	gold quality
middle temporal gyrus	UBERON:0002771	45.68	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
oviduct epithelium	UBERON:0004804	41.63	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	40.27	gold quality
jejunum	UBERON:0002115	40.18	gold quality
cartilage tissue	UBERON:0002418	40.06	gold quality
mammary duct	UBERON:0001765	39.98	gold quality
mucosa of sigmoid colon	UBERON:0004993	39.95	gold quality
colonic mucosa	UBERON:0000317	39.86	gold quality
deltoid	UBERON:0001476	39.83	gold quality
saphenous vein	UBERON:0007318	39.83	gold quality
parotid gland	UBERON:0001831	39.81	gold quality
urethra	UBERON:0000057	39.80	gold quality
heart right ventricle	UBERON:0002080	39.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.59

Regulation

Is transcription factor: no

Cross-species orthologs

27 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8g19	ENSMUSG00000049708
mus_musculus	Or8g30	ENSMUSG00000057349
mus_musculus	Or8g17	ENSMUSG00000058820
mus_musculus	Or8g21	ENSMUSG00000059595
mus_musculus	Or8g20	ENSMUSG00000062649
mus_musculus	Or8g28	ENSMUSG00000063380
mus_musculus	Or8g23	ENSMUSG00000094182
mus_musculus	Or8g32	ENSMUSG00000094269
mus_musculus	Or8g34	ENSMUSG00000094745
mus_musculus	Or8g26	ENSMUSG00000094970
mus_musculus	Or8g18	ENSMUSG00000096109
mus_musculus	Or8g27	ENSMUSG00000096555
rattus_norvegicus		ENSRNOG00000069156
rattus_norvegicus	Or8g18c	ENSRNOG00000069965
rattus_norvegicus	Or8g21	ENSRNOG00000070533
rattus_norvegicus	Or8g30	ENSRNOG00000073447
rattus_norvegicus	Or8g20e	ENSRNOG00000075099
rattus_norvegicus	Or8g34	ENSRNOG00000075420
rattus_norvegicus	Or8g34b	ENSRNOG00000075547
rattus_norvegicus	Or8g26c	ENSRNOG00000076721
rattus_norvegicus	Or8g26	ENSRNOG00000079933
rattus_norvegicus	Or8g28	ENSRNOG00000082314
rattus_norvegicus	Or8g23	ENSRNOG00000082549
rattus_norvegicus	Or8g17d	ENSRNOG00000082629
rattus_norvegicus	Or8g20b	ENSRNOG00000082989
rattus_norvegicus	Or8g20	ENSRNOG00000088588
rattus_norvegicus	Or8g18e	ENSRNOG00000090255

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 8G1 — Q15617 (reviewed: Q15617)

Alternative names: Olfactory receptor OR11-281, Olfactory receptor TPCR25

All UniProt accessions (2): A0A126GVX6, Q15617

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Polymorphism. A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity, thus producing a pseudogene.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001002905* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15617-F1	90.62	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 27 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, YOSHIMURA_MAPK8_TARGETS_UP, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, WP_GPCRS_OTHER

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

174 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8G1	H0YL38	H0YL38	433
OR8G1	ZNF280D	Q6N043	430
OR8G1	CRYBG2	Q8N1P7	430
OR8G1	CYLC1	P35663	418
OR8G1	KIAA1755	Q5JYT7	417
OR8G1	FTHL17	Q9BXU8	400
OR8G1	LCE1F	Q5T754	390
OR8G1	NIBAN2	Q96TA1	365
OR8G1	CDYL2	Q8N8U2	357
OR8G1	VWA5A	O00534	349
OR8G1	CHRNA10	Q9GZZ6	348
OR8G1	C2orf78	A6NCI8	348
OR8G1	GNG13	Q9P2W3	323
OR8G1	ACSM5	Q6NUN0	323
OR8G1	ZNF79	Q15937	320

IntAct

116 interactions, top by confidence:

A	B	Type	Score
OR8G1	MAST2	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	GRID2IP	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	TAMALIN	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	MAGI1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	SHANK1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	PDZD7	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	MAGI2	psi-mi:“MI:0407”(direct interaction)	0.440
MAGI3	OR8G1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	ARHGEF12	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	NHERF4	psi-mi:“MI:0407”(direct interaction)	0.440
PARD3B	OR8G1	psi-mi:“MI:0407”(direct interaction)	0.440
MAST1	OR8G1	psi-mi:“MI:0407”(direct interaction)	0.440
TJP2	OR8G1	psi-mi:“MI:0407”(direct interaction)	0.440
DLG1	OR8G1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	WHRN	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	SCRIB	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	GORASP1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	PICK1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	NOS1	psi-mi:“MI:0407”(direct interaction)	0.440
APBA3	OR8G1	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	TIAM2	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	IL16	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	RAPGEF6	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	APBA2	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	DLG3	psi-mi:“MI:0407”(direct interaction)	0.440
OR8G1	LIN7B	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (1): OR8G1 (Affinity Capture-MS)

ESM2 similar proteins: A6NCV1, A6NF89, A6NJZ3, A6NL08, A6NM76, O95221, P0C7N1, P0C7N5, P37070, P37071, P37072, Q15617, Q60886, Q6IEU7, Q8N127, Q8NGE1, Q8NGG0, Q8NGG8, Q8NGP8, Q8NGP9, Q8NGR8, Q8NGS9, Q8NGT0, Q8NGT1, Q8NGX3, Q8NH01, Q8NH10, Q8NH51, Q8NH69, Q8VEW5, Q8VF65, Q8VF66, Q8VF76, Q8VFD0, Q8VFD3, Q8VFK2, Q8VG02, Q8VG03, Q8VG04, Q8VG07

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 72 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Ras activation upon Ca2+ influx through NMDA receptor	5	59.5×	7e-07
Unblocking of NMDA receptors, glutamate binding and activation	5	56.6×	7e-07
Negative regulation of NMDA receptor-mediated neuronal transmission	5	56.6×	7e-07
Assembly and cell surface presentation of NMDA receptors	10	52.9×	2e-13
Dopamine Neurotransmitter Release Cycle	5	51.7×	1e-06
Long-term potentiation	5	49.6×	1e-06
Neurexins and neuroligins	11	45.1×	9e-14
Protein-protein interactions at synapses	7	38.7×	3e-08

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	11	92.6×	4e-17
protein localization to synapse	6	66.6×	4e-08
receptor clustering	7	63.3×	3e-09
regulation of postsynaptic membrane neurotransmitter receptor levels	6	43.1×	4e-07
cell-cell adhesion	10	14.7×	1e-07
protein-containing complex assembly	8	13.2×	8e-06
chemical synaptic transmission	7	7.8×	8e-04
intracellular signal transduction	8	4.4×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

29 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	25
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

322 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124249700:G:GG	donor_gain	0.8600
11:124249704:C:CG	donor_gain	0.8600
11:124249773:GAATC:G	donor_gain	0.8200
11:124249702:GAC:G	donor_gain	0.8100
11:124249699:A:AG	donor_gain	0.8000
11:124249790:GTG:G	donor_gain	0.8000
11:124249774:A:T	donor_gain	0.7600
11:124249700:GTGAC:G	donor_gain	0.7500
11:124249701:TGACT:T	donor_gain	0.7500
11:124249702:GACTG:G	donor_gain	0.7500
11:124249703:ACTGA:A	donor_gain	0.7500
11:124249704:C:G	donor_gain	0.7200
11:124249783:G:GA	donor_gain	0.7200
11:124249792:G:GA	donor_gain	0.6900
11:124249680:C:A	donor_gain	0.6800
11:124249866:GCA:G	acceptor_gain	0.6700
11:124249748:C:G	donor_gain	0.6600
11:124250088:A:AG	donor_gain	0.6600
11:124249868:A:AG	acceptor_gain	0.6500
11:124249869:G:GG	acceptor_gain	0.6500
11:124249914:A:G	acceptor_gain	0.6500
11:124250345:A:AG	acceptor_gain	0.6500
11:124250346:G:GG	acceptor_gain	0.6500
11:124249677:T:G	donor_gain	0.6400
11:124250346:GCAT:G	acceptor_gain	0.6400
11:124249683:G:GT	donor_gain	0.6300
11:124249807:C:T	donor_gain	0.6300
11:124249826:C:G	donor_gain	0.6300
11:124249869:GTCT:G	acceptor_gain	0.6100
11:124250331:T:G	acceptor_gain	0.6100

AlphaMissense

2056 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:124249709:T:C	F12L	0.918
11:124249711:C:A	F12L	0.918
11:124249711:C:G	F12L	0.918
11:124250546:A:C	S291R	0.850
11:124250548:C:A	S291R	0.850
11:124250548:C:G	S291R	0.850
11:124249710:T:C	F12S	0.841
11:124250177:T:C	F168L	0.835
11:124250179:C:A	F168L	0.835
11:124250179:C:G	F168L	0.835
11:124250207:T:C	F178L	0.827
11:124250209:C:A	F178L	0.827
11:124250209:C:G	F178L	0.827
11:124250306:A:C	S211R	0.827
11:124250308:C:A	S211R	0.827
11:124250308:C:G	S211R	0.827
11:124250429:T:C	F252L	0.827
11:124250431:T:A	F252L	0.827
11:124250431:T:G	F252L	0.827
11:124249766:T:C	F31L	0.816
11:124249768:C:A	F31L	0.816
11:124249768:C:G	F31L	0.816
11:124250533:C:A	N286K	0.788
11:124250533:C:G	N286K	0.788
11:124250383:A:C	K236N	0.784
11:124250383:A:T	K236N	0.784
11:124250399:A:C	S242R	0.774
11:124250401:C:A	S242R	0.774
11:124250401:C:G	S242R	0.774
11:124250210:T:A	C179S	0.769

dbSNP variants (sampled 300 via entrez): RS1000660106 (11:124254188 T>C), RS1001151606 (11:124240716 G>A), RS1001153944 (11:124252524 G>A,T), RS1001437572 (11:124239468 T>A), RS1001712152 (11:124241737 G>A), RS1001720017 (11:124244583 A>G), RS1001762011 (11:124252067 A>G), RS1001892493 (11:124246572 A>G), RS1001953828 (11:124247711 AAGAGAGAGAGGG>A), RS1002013409 (11:124240871 T>G), RS1002784950 (11:124251792 T>G), RS1002989158 (11:124243247 A>G), RS1003160880 (11:124248725 A>G,T), RS1003686177 (11:124239175 A>C), RS1003852265 (11:124243754 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation, increases methylation	2
ferrous chloride	increases expression	1
CGP 52608	affects binding, increases reaction	1
Acetaminophen	decreases expression	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.