OR8G3

Summary

OR8G3 (olfactory receptor family 8 subfamily G member 3 (gene/pseudogene), HGNC:14698) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 8G3 (P0DMU2). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 387815 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14698
Approved symbol	OR8G3
Name	olfactory receptor family 8 subfamily G member 3 (gene/pseudogene)
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000255425
Ensembl biotype	protein_coding
Entrez	387815

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding_LoF

ENST00000641572, ENST00000641848

RefSeq mRNA: 0 — MANE Select: None

CCDS: CCDS91615

Canonical transcript exons

ENST00000641572 — 2 exons

Exon	Start	End
ENSE00003811791	124211707	124211870
ENSE00003812127	124214738	124215828

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 89.53.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.53	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.62	gold quality
mucosa of transverse colon	UBERON:0004991	48.49	gold quality
testis	UBERON:0000473	45.92	gold quality
left testis	UBERON:0004533	45.67	gold quality
right testis	UBERON:0004534	45.61	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.43	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
placenta	UBERON:0001987	29.62	silver quality
prefrontal cortex	UBERON:0000451	29.38	gold quality
monocyte	CL:0000576	29.13	gold quality
leukocyte	CL:0000738	28.99	gold quality
liver	UBERON:0002107	28.86	gold quality
gall bladder	UBERON:0002110	28.65	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.78	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
superior frontal gyrus	UBERON:0002661	27.02	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8g2b	ENSMUSG00000093934
mus_musculus	Or8g2	ENSMUSG00000095390
rattus_norvegicus		ENSRNOG00000082990
rattus_norvegicus	Or8g2c	ENSRNOG00000089100

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 8G3 — P0DMU2 (reviewed: P0DMU2)

Alternative names: Olfactory receptor OR11-297

All UniProt accessions (1): Q8NG87

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DMU2-F1	90.23	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 15 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, DACH1_TARGET_GENES, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, GOBP_NERVOUS_SYSTEM_PROCESS

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O43749, O76001, O76002, O76100, O95006, P0DMU2, P23266, P23269, P23272, P23274, P30953, P30955, P58173, P59922, P70526, Q13607, Q15619, Q60890, Q6UXT6, Q8N148, Q8N628, Q8NGA6, Q8NGL2, Q8NGS0, Q8NGS2, Q8NGX8, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NH04, Q8VGI1, Q8VGK5, Q8VGR9, Q95156, Q96R09, Q96R47, Q96R48, Q96R84, Q9GZK6

Diamond homologs: A4D2G3, A6ND48, A6NL26, O43749, O60412, O76099, P0C7N5, P0DMU2, P0DN82, P23265, P23266, P23269, P23272, P23273, P23274, P30953, P30955, P34984, P34985, P34986, P35896, P47887, P47890, P58173, P58181, P58182, P70526, Q0VAX9, Q13606, Q13607, Q15617, Q15619, Q60893, Q6IFN5, Q6UXT6, Q7TQQ0, Q7TRF3, Q8N127, Q8NG98, Q8NGA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000084746 (11:124210913 A>G), RS1000474550 (11:124210043 G>T), RS1000734199 (11:124212254 A>G), RS1000800710 (11:124213677 A>C), RS1001104273 (11:124212530 A>G), RS1001574913 (11:124214636 T>C), RS1002129480 (11:124213548 G>A), RS1003104034 (11:124209797 G>A,C), RS1003977853 (11:124213250 G>A), RS1004665145 (11:124214704 A>C,G), RS1006666821 (11:124215233 C>A,G), RS1006685489 (11:124211764 C>T), RS1006717364 (11:124215490 T>A), RS1006965344 (11:124210237 G>C,T), RS1007340769 (11:124214786 A>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.