OR8G5

Summary

OR8G5 (olfactory receptor family 8 subfamily G member 5, HGNC:19622) is a protein-coding gene on chromosome 11q24.2, encoding Olfactory receptor 8G5 (Q8NG78). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219865 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 52 total — 1 pathogenic
• MANE Select transcript: NM_001005198

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19622
Approved symbol	OR8G5
Name	olfactory receptor family 8 subfamily G member 5
Location	11q24.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000255298
Ensembl biotype	protein_coding
Entrez	219865

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641707, ENST00000641992

RefSeq mRNA: 1 — MANE Select: NM_001005198 NM_001005198

CCDS: CCDS66256

Canonical transcript exons

ENST00000641992 — 2 exons

Exon	Start	End
ENSE00003811991	124264918	124266224
ENSE00003812384	124256376	124256634

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 86.72.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0265 / max 16.2905, expressed in 6 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117359	0.0265	6

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.19	gold quality
left testis	UBERON:0004533	56.81	gold quality
testis	UBERON:0000473	56.60	gold quality
right testis	UBERON:0004534	53.83	gold quality
placenta	UBERON:0001987	48.21	gold quality
bone marrow cell	CL:0002092	38.70	gold quality
duodenum	UBERON:0002114	37.92	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	36.80	gold quality
mucosa of transverse colon	UBERON:0004991	36.66	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
mucosa of stomach	UBERON:0001199	35.97	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.38	gold quality
bone marrow	UBERON:0002371	34.24	gold quality
muscle tissue	UBERON:0002385	33.81	gold quality
transverse colon	UBERON:0001157	33.18	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
rectum	UBERON:0001052	31.17	gold quality
urinary bladder	UBERON:0001255	31.03	silver quality
lower esophagus muscularis layer	UBERON:0035833	30.43	gold quality
lower esophagus	UBERON:0013473	30.38	gold quality
upper lobe of left lung	UBERON:0008952	30.02	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
vermiform appendix	UBERON:0001154	29.66	gold quality
lung	UBERON:0002048	29.56	gold quality
monocyte	CL:0000576	29.50	gold quality
leukocyte	CL:0000738	29.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.79

Regulation

Is transcription factor: no

Cross-species orthologs

27 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8g19	ENSMUSG00000049708
mus_musculus	Or8g30	ENSMUSG00000057349
mus_musculus	Or8g17	ENSMUSG00000058820
mus_musculus	Or8g21	ENSMUSG00000059595
mus_musculus	Or8g20	ENSMUSG00000062649
mus_musculus	Or8g28	ENSMUSG00000063380
mus_musculus	Or8g23	ENSMUSG00000094182
mus_musculus	Or8g32	ENSMUSG00000094269
mus_musculus	Or8g34	ENSMUSG00000094745
mus_musculus	Or8g26	ENSMUSG00000094970
mus_musculus	Or8g18	ENSMUSG00000096109
mus_musculus	Or8g27	ENSMUSG00000096555
rattus_norvegicus		ENSRNOG00000069156
rattus_norvegicus	Or8g18c	ENSRNOG00000069965
rattus_norvegicus	Or8g21	ENSRNOG00000070533
rattus_norvegicus	Or8g30	ENSRNOG00000073447
rattus_norvegicus	Or8g20e	ENSRNOG00000075099
rattus_norvegicus	Or8g34	ENSRNOG00000075420
rattus_norvegicus	Or8g34b	ENSRNOG00000075547
rattus_norvegicus	Or8g26c	ENSRNOG00000076721
rattus_norvegicus	Or8g26	ENSRNOG00000079933
rattus_norvegicus	Or8g28	ENSRNOG00000082314
rattus_norvegicus	Or8g23	ENSRNOG00000082549
rattus_norvegicus	Or8g17d	ENSRNOG00000082629
rattus_norvegicus	Or8g20b	ENSRNOG00000082989
rattus_norvegicus	Or8g20	ENSRNOG00000088588
rattus_norvegicus	Or8g18e	ENSRNOG00000090255

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 8G5 — Q8NG78 (reviewed: Q8NG78)

Alternative names: Olfactory receptor 8G6, Olfactory receptor OR11-298

All UniProt accessions (1): A0A126GW95

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005198* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG78-F1	83.27	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 132–214

Glycosylation sites (2): 16, 40

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr11q24, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

190 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8G5	SLC24A3	Q9HC58	514
OR8G5	PLBD2	Q8NHP8	470
OR8G5	GPAA1	O43292	378
OR8G5	H0YL38	H0YL38	369
OR8G5	ZNF280D	Q6N043	365
OR8G5	CRYBG2	Q8N1P7	360
OR8G5	GAS2L2	Q8NHY3	359
OR8G5	ALPG	P10696	350
OR8G5	KIAA1755	Q5JYT7	349
OR8G5	YBX2	Q9Y2T7	348
OR8G5	QRICH2	Q9H0J4	348
OR8G5	LDHAL6B	Q9BYZ2	332
OR8G5	TMEM87A	Q8NBN3	325
OR8G5	SCUBE2	Q9NQ36	323
OR8G5	TYW1	Q9NV66	323

IntAct

0 interactions, top by confidence:

BioGRID (1): OR8G5 (Protein-RNA)

ESM2 similar proteins: A6ND48, A6NFC9, B2RN74, O43869, O60412, O60431, P23265, P31388, P34987, P47883, P47884, P47887, P58170, Q0VAX9, Q5JRS4, Q60894, Q6IFN5, Q7Z3T1, Q8NG78, Q8NG84, Q8NG94, Q8NG99, Q8NGC0, Q8NGC1, Q8NGC5, Q8NGE7, Q8NGG2, Q8NGG3, Q8NGN1, Q8NGN2, Q8NGR1, Q8NGR2, Q8NGR6, Q8NGT2, Q8NGW1, Q8NGW6, Q8NGZ2, Q8NGZ5, Q8NH06, Q8NH07

Diamond homologs: A6NDH6, A6NET4, A6NHG9, A6NKK0, A6NL26, A6NMS3, O95221, P0C626, P0C628, P0C7N1, P0C7N5, P0DMU2, P0DN80, P34985, P37068, P37070, P37071, P37072, Q13606, Q15617, Q15620, Q60880, Q60882, Q60884, Q60886, Q60893, Q60894, Q6UXT6, Q7TS48, Q8N127, Q8N146, Q8N162, Q8NG75, Q8NG78, Q8NGC0, Q8NGF4, Q8NGF7, Q8NGG0, Q8NGG1, Q8NGG2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	47
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
150820	GRCh38/hg38 11q24.1-25(chr11:121689052-135075271)x1	Pathogenic

SpliceAI

231 predictions. Top by Δscore:

Variant	Effect	Δscore
11:124265038:T:TA	donor_gain	0.9600
11:124265039:A:AA	donor_gain	0.9600
11:124265029:GAATC:G	donor_gain	0.8000
11:124265036:T:G	donor_gain	0.6800
11:124265344:A:AG	donor_gain	0.6400
11:124264988:G:GT	donor_gain	0.6300
11:124265029:G:T	donor_gain	0.6200
11:124264958:GAC:G	donor_gain	0.5800
11:124264998:C:G	donor_gain	0.5800
11:124265040:G:GG	donor_gain	0.5800
11:124264960:C:CG	donor_gain	0.5600
11:124264866:GAGAA:G	donor_gain	0.5500
11:124265033:C:CG	donor_gain	0.5400
11:124265697:GCATT:G	acceptor_gain	0.5400
11:124264986:GAGAA:G	donor_gain	0.5300
11:124264960:C:G	donor_gain	0.5100
11:124265688:G:A	acceptor_gain	0.5000
11:124264956:GTGAC:G	donor_gain	0.4900
11:124264957:TGACT:T	donor_gain	0.4900
11:124265033:C:G	donor_gain	0.4900
11:124265104:C:G	donor_gain	0.4800
11:124265601:A:AG	acceptor_gain	0.4800
11:124265602:G:GG	acceptor_gain	0.4800
11:124264958:GACTA:G	donor_gain	0.4700
11:124264959:ACTAA:A	donor_gain	0.4700
11:124265697:GC:G	acceptor_gain	0.4700
11:124265107:T:G	donor_gain	0.4600
11:124265559:CCCAG:C	acceptor_gain	0.4600
11:124265560:CCAGC:C	acceptor_gain	0.4600
11:124265561:CAGCC:C	acceptor_gain	0.4600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000135627 (11:124261045 G>A,T), RS1000293379 (11:124255371 T>A), RS1000324015 (11:124255709 C>CT), RS1000416941 (11:124260170 C>T), RS1000438776 (11:124255961 T>C), RS1000681835 (11:124261674 G>A,C), RS1001097405 (11:124266248 GT>G,GTT), RS1001699599 (11:124258942 A>G), RS1002082363 (11:124256927 A>G), RS1002433128 (11:124257367 A>G), RS1003445747 (11:124262112 G>T), RS1003478935 (11:124262405 A>C), RS1003529145 (11:124261768 A>G), RS1003701024 (11:124255748 A>G), RS1003978824 (11:124257413 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
CGP 52608	affects binding, increases reaction	1
Lipopolysaccharides	increases expression, affects cotreatment, affects response to substance	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.