OR8H2

Summary

OR8H2 (olfactory receptor family 8 subfamily H member 2, HGNC:15308) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 8H2 (Q8N162). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390151 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 55 total
• MANE Select transcript: NM_001386064

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15308
Approved symbol	OR8H2
Name	olfactory receptor family 8 subfamily H member 2
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181767
Ensembl biotype	protein_coding
Entrez	390151

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000313503, ENST00000618136, ENST00000641311

RefSeq mRNA: 2 — MANE Select: NM_001386064 NM_001005200, NM_001386064

CCDS: CCDS31518

Canonical transcript exons

ENST00000313503 — 2 exons

Exon	Start	End
ENSE00001271073	56104872	56107658
ENSE00003811705	56103687	56103987

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 41.34.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	41.34	gold quality
granulocyte	CL:0000094	40.59	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
mucosa of stomach	UBERON:0001199	32.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
liver	UBERON:0002107	30.46	gold quality
leukocyte	CL:0000738	29.94	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.40	gold quality
prefrontal cortex	UBERON:0000451	29.19	gold quality
tonsil	UBERON:0002372	28.69	gold quality
duodenum	UBERON:0002114	28.14	gold quality
right lobe of liver	UBERON:0001114	27.98	gold quality
lymph node	UBERON:0000029	27.57	gold quality
blood	UBERON:0000178	27.55	gold quality
placenta	UBERON:0001987	27.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.28	gold quality
islet of Langerhans	UBERON:0000006	27.23	gold quality
superior frontal gyrus	UBERON:0002661	26.80	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
muscle of leg	UBERON:0001383	25.79	gold quality
pancreas	UBERON:0001264	24.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.11

Regulation

Is transcription factor: no

Cross-species orthologs

13 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8h10	ENSMUSG00000070875
mus_musculus	Or8h9	ENSMUSG00000075168
mus_musculus	Or8h8	ENSMUSG00000075169
mus_musculus	Or8h7	ENSMUSG00000075170
mus_musculus	Or8h6	ENSMUSG00000086338
rattus_norvegicus		ENSRNOG00000072999
rattus_norvegicus	Or8h7b	ENSRNOG00000073800
rattus_norvegicus	Or8h6	ENSRNOG00000076696
rattus_norvegicus	Or8h10c	ENSRNOG00000080512
rattus_norvegicus	Or8h10	ENSRNOG00000081867
rattus_norvegicus	Or8h11	ENSRNOG00000088724
rattus_norvegicus	Or8h9	ENSRNOG00000089485
rattus_norvegicus	Or8h7	ENSRNOG00000089624

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761)

Protein

Protein identifiers

Olfactory receptor 8H2 — Q8N162 (reviewed: Q8N162)

Alternative names: Olfactory receptor OR11-171

All UniProt accessions (2): A0A087WZH1, Q8N162

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001005200, NP_001372993* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N162-F1	88.31	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

162 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8H2	TRIM48	Q8IWZ4	447
OR8H2	TRIM51	Q9BSJ1	431
OR8H2	ZNF737	O75373	322
OR8H2	CSPP1	Q1MSJ5	310
OR8H2	SIRPB1	O00241	273
OR8H2	CFAP47	Q6ZTR5	256
OR8H2	POTEM	A6NI47	250
OR8H2	TOMM20L	Q6UXN7	247
OR8H2	VWA3B	Q502W6	245
OR8H2	DCTN2	Q13561	233
OR8H2	TM4SF20	Q53R12	205
OR8H2	MT1HL1	P0DM35	204
OR8H2	RAPGEFL1	Q9UHV5	203
OR8H2	KIF25	Q9UIL4	203
OR8H2	NPIPA5	E9PKD4	201

IntAct

0 interactions, top by confidence:

BioGRID (2): OR8H2 (Affinity Capture-MS), OR8H2 (Affinity Capture-Luminescence)

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

203 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56105781:G:GT	donor_gain	0.7300
11:56105327:G:A	acceptor_gain	0.6300
11:56105326:C:CA	acceptor_gain	0.6200
11:56105884:T:TA	acceptor_gain	0.6100
11:56105912:TAG:T	acceptor_gain	0.6100
11:56105598:GCTCT:G	acceptor_gain	0.6000
11:56105057:G:GT	donor_gain	0.5900
11:56105681:A:AG	acceptor_gain	0.5900
11:56105913:A:AG	acceptor_gain	0.5800
11:56105914:G:GG	acceptor_gain	0.5800
11:56105914:G:T	acceptor_gain	0.5800
11:56105781:G:T	donor_gain	0.5700
11:56105913:A:T	acceptor_gain	0.5600
11:56105363:G:A	acceptor_gain	0.5500
11:56105880:ATTGT:A	acceptor_gain	0.5500
11:56105882:T:A	acceptor_gain	0.5400
11:56105051:TAG:T	donor_gain	0.5300
11:56105052:AGA:A	donor_gain	0.5300
11:56105395:T:TA	acceptor_gain	0.5300
11:56105914:GTCTT:G	acceptor_gain	0.5300
11:56105393:AAT:A	acceptor_gain	0.5100
11:56105823:A:G	acceptor_gain	0.4900
11:56105362:T:A	acceptor_gain	0.4700
11:56105559:G:GG	donor_gain	0.4700
11:56105822:A:AG	acceptor_gain	0.4700
11:56105046:A:G	donor_gain	0.4600
11:56105221:T:G	donor_gain	0.4600
11:56105393:A:AG	acceptor_gain	0.4600
11:56105482:GGCCT:G	donor_gain	0.4600
11:56105914:GT:G	acceptor_gain	0.4600

AlphaMissense

2054 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56105079:T:C	F13L	0.843
11:56105081:C:A	F13L	0.843
11:56105081:C:G	F13L	0.843
11:56105259:A:C	S73R	0.826
11:56105261:T:A	S73R	0.826
11:56105261:T:G	S73R	0.826
11:56105913:A:C	S291R	0.816
11:56105915:T:A	S291R	0.816
11:56105915:T:G	S291R	0.816
11:56105544:T:C	F168L	0.793
11:56105546:C:A	F168L	0.793
11:56105546:C:G	F168L	0.793
11:56105571:T:C	F177L	0.789
11:56105573:T:A	F177L	0.789
11:56105573:T:G	F177L	0.789
11:56105799:A:C	S253R	0.789
11:56105801:C:A	S253R	0.789
11:56105801:C:G	S253R	0.789
11:56105407:G:C	R122P	0.764
11:56105396:G:A	M118I	0.763
11:56105396:G:C	M118I	0.763
11:56105396:G:T	M118I	0.763
11:56105793:T:C	F251L	0.763
11:56105795:T:A	F251L	0.763
11:56105795:T:G	F251L	0.763
11:56105136:T:C	F32L	0.759
11:56105138:T:A	F32L	0.759
11:56105138:T:G	F32L	0.759
11:56105574:T:C	F178L	0.744
11:56105576:C:A	F178L	0.744

dbSNP variants (sampled 300 via entrez): RS1000847903 (11:56103703 TGTG>T), RS1001541894 (11:56106109 T>A), RS1002726873 (11:56102364 G>A,C), RS1003105677 (11:56102525 A>C), RS1005035507 (11:56106073 C>A), RS1005410457 (11:56105862 G>A), RS1005666119 (11:56103121 A>G), RS1006052210 (11:56102356 G>A,T), RS1006686398 (11:56104184 T>C), RS1006800806 (11:56104394 C>T), RS1008215745 (11:56101810 A>T), RS1008767986 (11:56102055 C>T), RS1011270711 (11:56106129 T>A), RS1011554565 (11:56106379 G>A), RS1011763084 (11:56101758 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005024_18	Pursuit maintenance gain	4.000000e-06
GCST90000025_158	Appendicular lean mass	3.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008433	pursuit maintenance gain measurement
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
propionaldehyde	decreases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.