OR8H3

Summary

OR8H3 (olfactory receptor family 8 subfamily H member 3, HGNC:15309) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 8H3 (Q8N146). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390152 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 55 total
• MANE Select transcript: NM_001005201

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15309
Approved symbol	OR8H3
Name	olfactory receptor family 8 subfamily H member 3
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181761
Ensembl biotype	protein_coding
Entrez	390152

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000313472

RefSeq mRNA: 1 — MANE Select: NM_001005201 NM_001005201

CCDS: CCDS31519

Canonical transcript exons

ENST00000313472 — 1 exons

Exon	Start	End
ENSE00001271051	56122373	56123311

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 38.03.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	38.03	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.70	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
monocyte	CL:0000576	28.54	gold quality
urinary bladder	UBERON:0001255	28.48	gold quality
leukocyte	CL:0000738	28.45	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
blood	UBERON:0000178	26.43	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.30	gold quality
calcaneal tendon	UBERON:0003701	25.06	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.51	gold quality
gastrocnemius	UBERON:0001388	24.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Cross-species orthologs

13 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8h10	ENSMUSG00000070875
mus_musculus	Or8h9	ENSMUSG00000075168
mus_musculus	Or8h8	ENSMUSG00000075169
mus_musculus	Or8h7	ENSMUSG00000075170
mus_musculus	Or8h6	ENSMUSG00000086338
rattus_norvegicus		ENSRNOG00000072999
rattus_norvegicus	Or8h7b	ENSRNOG00000073800
rattus_norvegicus	Or8h6	ENSRNOG00000076696
rattus_norvegicus	Or8h10c	ENSRNOG00000080512
rattus_norvegicus	Or8h10	ENSRNOG00000081867
rattus_norvegicus	Or8h11	ENSRNOG00000088724
rattus_norvegicus	Or8h9	ENSRNOG00000089485
rattus_norvegicus	Or8h7	ENSRNOG00000089624

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 8H3 — Q8N146 (reviewed: Q8N146)

Alternative names: Olfactory receptor OR11-172

All UniProt accessions (1): Q8N146

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005201* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N146-F1	88.11	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

230 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8H3	FAM217A	Q8IXS0	571
OR8H3	TEX22	C9J3V5	506
OR8H3	RSPH10B2	B2RC85	480
OR8H3	MROH9	Q5TGP6	479
OR8H3	RSPH10B	P0C881	445
OR8H3	CCDC81	Q6ZN84	432
OR8H3	MFSD6L	Q8IWD5	430
OR8H3	TMPRSS12	Q86WS5	417
OR8H3	TRIM48	Q8IWZ4	417
OR8H3	TRIM51	Q9BSJ1	397
OR8H3	KRTCAP3	Q53RY4	391
OR8H3	MIMS1	Q96ND0	377
OR8H3	ESPNL	Q6ZVH7	375
OR8H3	GPR62	Q9BZJ7	370
OR8H3	PCDHGA6	Q9Y5G7	370

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

257 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56122928:GCTCT:G	acceptor_gain	0.7700
11:56122387:G:GT	donor_gain	0.7500
11:56123111:G:GT	donor_gain	0.7100
11:56122656:C:CA	acceptor_gain	0.6900
11:56122723:AAT:A	acceptor_gain	0.6900
11:56122725:T:TA	acceptor_gain	0.6900
11:56122927:A:AG	acceptor_gain	0.6900
11:56122928:G:GG	acceptor_gain	0.6900
11:56122723:A:AG	acceptor_gain	0.6400
11:56122657:G:A	acceptor_gain	0.6300
11:56122422:G:T	donor_gain	0.6200
11:56122928:GCT:G	acceptor_gain	0.6200
11:56122381:TAG:T	donor_gain	0.6100
11:56122382:AGA:A	donor_gain	0.6100
11:56122439:GAG:G	donor_gain	0.6100
11:56122981:T:A	acceptor_gain	0.6100
11:56122923:TTTTA:T	acceptor_loss	0.6000
11:56122924:TTTA:T	acceptor_loss	0.6000
11:56122925:TTAGC:T	acceptor_loss	0.6000
11:56122926:TA:T	acceptor_loss	0.6000
11:56122928:G:GT	acceptor_loss	0.6000
11:56123111:G:T	donor_gain	0.6000
11:56122422:G:GT	donor_gain	0.5900
11:56122428:C:A	donor_gain	0.5900
11:56122463:C:G	donor_gain	0.5800
11:56122376:A:G	donor_gain	0.5700
11:56123242:TAG:T	acceptor_gain	0.5700
11:56122812:GGCCT:G	donor_gain	0.5600
11:56123026:T:G	acceptor_gain	0.5600
11:56123042:A:AG	acceptor_gain	0.5600

AlphaMissense

2052 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56122409:T:C	F13L	0.906
11:56122411:C:A	F13L	0.906
11:56122411:C:G	F13L	0.906
11:56122874:T:C	F168L	0.891
11:56122876:C:A	F168L	0.891
11:56122876:C:G	F168L	0.891
11:56123243:A:C	S291R	0.852
11:56123245:T:A	S291R	0.852
11:56123245:T:G	S291R	0.852
11:56122901:T:C	F177L	0.850
11:56122903:T:A	F177L	0.850
11:56122903:T:G	F177L	0.850
11:56122737:G:C	R122P	0.844
11:56122589:A:C	S73R	0.842
11:56122591:T:A	S73R	0.842
11:56122591:T:G	S73R	0.842
11:56122466:T:C	F32L	0.823
11:56122468:T:A	F32L	0.823
11:56122468:T:G	F32L	0.823
11:56122904:T:C	F178L	0.821
11:56122906:C:A	F178L	0.821
11:56122906:C:G	F178L	0.821
11:56122726:G:A	M118I	0.814
11:56122726:G:C	M118I	0.814
11:56122726:G:T	M118I	0.814
11:56122907:T:A	C179S	0.814
11:56122908:G:C	C179S	0.814
11:56122735:T:A	D121E	0.809
11:56122735:T:G	D121E	0.809
11:56122501:T:A	N43K	0.800

dbSNP variants (sampled 300 via entrez): RS1000017902 (11:56122442 G>A), RS1000623333 (11:56123285 A>C,G), RS1001465091 (11:56121130 A>T), RS1001832924 (11:56120888 C>T), RS1003774656 (11:56121954 A>G), RS1003868318 (11:56121871 TC>T,TCC), RS1004421828 (11:56121666 G>C,T), RS1007216616 (11:56123788 T>A,C), RS1007769664 (11:56123601 T>G), RS1007985221 (11:56121358 G>A), RS1011115552 (11:56122225 T>C), RS1011146496 (11:56122403 G>C), RS1011448493 (11:56121152 C>T), RS1011482703 (11:56121354 C>T), RS1013628177 (11:56120846 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005580_82	Intraocular pressure	2.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	2
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.