OR8J3

Summary

OR8J3 (olfactory receptor family 8 subfamily J member 3, HGNC:15312) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 8J3 (Q8NGG0). Odorant receptor.

Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane.

Source: NCBI Gene 81168 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 45 total
• MANE Select transcript: NM_001004064

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15312
Approved symbol	OR8J3
Name	olfactory receptor family 8 subfamily J member 3
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000167822
Ensembl biotype	protein_coding
Entrez	81168

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000641489, ENST00000641913, ENST00000642058

RefSeq mRNA: 1 — MANE Select: NM_001004064 NM_001004064

CCDS: CCDS31520

Canonical transcript exons

ENST00000642058 — 2 exons

Exon	Start	End
ENSE00003813011	56134721	56138497
ENSE00003814056	56140173	56140201

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.80.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	37.80	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
granulocyte	CL:0000094	34.16	gold quality
monocyte	CL:0000576	33.92	gold quality
leukocyte	CL:0000738	33.82	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
muscle tissue	UBERON:0002385	32.28	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.71	gold quality
tonsil	UBERON:0002372	28.54	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.66	gold quality
lymph node	UBERON:0000029	27.57	gold quality
blood	UBERON:0000178	26.86	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
adrenal tissue	UBERON:0018303	26.49	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.18	gold quality
pancreas	UBERON:0001264	25.00	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.77

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8j3	ENSMUSG00000075198
rattus_norvegicus	Or8j3	ENSRNOG00000066809

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 8J3 — Q8NGG0 (reviewed: Q8NGG0)

Alternative names: Olfactory receptor OR11-173

All UniProt accessions (2): A0A126GVE3, Q8NGG0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004064* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 4, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGG0-F1	89.50	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 265

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_B, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

146 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8J3	TRIM48	Q8IWZ4	505
OR8J3	TRIM51	Q9BSJ1	476
OR8J3	ZNF737	O75373	369
OR8J3	CFAP47	Q6ZTR5	300
OR8J3	POTEM	A6NI47	295
OR8J3	VWA3B	Q502W6	276
OR8J3	TM4SF20	Q53R12	246
OR8J3	ANTXR1	Q9H6X2	228
OR8J3	NPIPA5	E9PKD4	228
OR8J3	ZNF277	Q9NRM2	225
OR8J3	FRMD1	Q8N878	224
OR8J3	NPIPA3	F8WFD2	224
OR8J3	KIF25	Q9UIL4	224
OR8J3	CEP20	Q96NB1	220
OR8J3	ZNF385D	Q9H6B1	210

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NCV1, A6NF89, A6NJZ3, A6NL08, A6NM76, O95221, P0C7N1, P0C7N5, P37070, P37071, P37072, Q15617, Q60886, Q6IEU7, Q8N127, Q8NGE1, Q8NGG0, Q8NGG8, Q8NGP8, Q8NGP9, Q8NGR8, Q8NGS9, Q8NGT0, Q8NGT1, Q8NGX3, Q8NH01, Q8NH10, Q8NH51, Q8NH69, Q8VEW5, Q8VF65, Q8VF66, Q8VF76, Q8VFD0, Q8VFD3, Q8VFK2, Q8VG02, Q8VG03, Q8VG04, Q8VG07

Diamond homologs: A0A2R8YED5, O14581, O43749, O76099, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23275, P30955, P47890, P58173, P58181, P59922, Q15617, Q15619, Q15622, Q60878, Q60881, Q60895, Q6IEU7, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N0Y5, Q8N146, Q8N162, Q8N628, Q8NG98, Q8NGA1, Q8NGC2, Q8NGE5, Q8NGF4, Q8NGF8, Q8NGG0, Q8NGG3, Q8NGG4, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

192 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56137543:A:C	donor_gain	0.8200
11:56137252:G:C	donor_gain	0.7800
11:56136879:CAATG:C	acceptor_gain	0.7600
11:56137038:CCT:C	acceptor_gain	0.6900
11:56137040:T:C	acceptor_gain	0.6700
11:56136883:G:C	acceptor_gain	0.6500
11:56137519:G:C	donor_gain	0.6500
11:56137688:CAGTG:C	donor_gain	0.6500
11:56137689:AGTGA:A	donor_gain	0.6500
11:56137244:C:CT	donor_gain	0.6400
11:56137316:C:CT	donor_gain	0.6300
11:56137689:A:AC	donor_gain	0.6300
11:56137040:T:TC	acceptor_gain	0.6100
11:56137459:A:AC	donor_gain	0.6000
11:56137460:C:CC	donor_gain	0.6000
11:56137538:A:C	donor_gain	0.6000
11:56137037:TC:T	acceptor_gain	0.5900
11:56137045:A:AC	acceptor_gain	0.5900
11:56137313:C:CT	donor_gain	0.5900
11:56137413:T:A	donor_gain	0.5900
11:56137414:C:CA	donor_gain	0.5900
11:56137454:T:TA	donor_gain	0.5900
11:56137596:C:A	donor_gain	0.5900
11:56136883:G:GC	acceptor_gain	0.5800
11:56137503:G:A	donor_gain	0.5800
11:56137541:A:AC	donor_gain	0.5800
11:56137542:C:CC	donor_gain	0.5800
11:56137039:C:CC	acceptor_gain	0.5700
11:56137039:C:T	acceptor_gain	0.5600
11:56137045:A:C	acceptor_gain	0.5600

AlphaMissense

2060 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56137683:A:C	F12L	0.921
11:56137683:A:T	F12L	0.921
11:56137685:A:G	F12L	0.921
11:56137188:A:C	F177L	0.908
11:56137188:A:T	F177L	0.908
11:56137190:A:G	F177L	0.908
11:56137227:G:C	F164L	0.853
11:56137227:G:T	F164L	0.853
11:56137229:A:G	F164L	0.853
11:56137407:G:C	F104L	0.853
11:56137407:G:T	F104L	0.853
11:56137409:A:G	F104L	0.853
11:56137684:A:G	F12S	0.850
11:56137365:C:A	M118I	0.848
11:56137365:C:G	M118I	0.848
11:56137365:C:T	M118I	0.848
11:56137354:C:G	R122P	0.837
11:56136846:G:C	S291R	0.824
11:56136846:G:T	S291R	0.824
11:56136848:T:G	S291R	0.824
11:56136966:G:C	F251L	0.822
11:56136966:G:T	F251L	0.822
11:56136968:A:G	F251L	0.822
11:56137509:A:C	N70K	0.817
11:56137509:A:T	N70K	0.817
11:56136888:A:C	F277L	0.811
11:56136888:A:T	F277L	0.811
11:56136890:A:G	F277L	0.811
11:56137005:A:C	F238L	0.790
11:56137005:A:T	F238L	0.790

dbSNP variants (sampled 300 via entrez): RS1000569534 (11:56138492 C>A,T), RS1000875825 (11:56140069 G>A), RS1000989856 (11:56140427 T>C), RS1001192874 (11:56138709 T>A), RS1001645896 (11:56136700 T>C), RS1001884252 (11:56141412 C>T), RS1001977893 (11:56135212 T>C), RS1002079244 (11:56138174 A>G), RS1002516652 (11:56137801 A>G), RS1002632427 (11:56138119 A>G), RS1002662113 (11:56138429 A>G), RS1003190788 (11:56135060 A>C), RS1003624053 (11:56142085 T>A), RS1004083822 (11:56140741 C>T), RS1004517359 (11:56140625 T>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Fulvestrant	decreases methylation	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Coal	increases abundance, increases expression	1
Smoke	increases abundance, increases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.