OR8K5

Summary

OR8K5 (olfactory receptor family 8 subfamily K member 5, HGNC:15315) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 8K5 (Q8NH50). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219453 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_001004058

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15315
Approved symbol	OR8K5
Name	olfactory receptor family 8 subfamily K member 5
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181752
Ensembl biotype	protein_coding
Entrez	219453

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000313447

RefSeq mRNA: 1 — MANE Select: NM_001004058 NM_001004058

CCDS: CCDS31521

Canonical transcript exons

ENST00000313447 — 1 exons

Exon	Start	End
ENSE00001271035	56159394	56160317

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 85.31.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.31	gold quality
granulocyte	CL:0000094	38.31	gold quality
ganglionic eminence	UBERON:0004023	37.61	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.64	gold quality
leukocyte	CL:0000738	28.25	gold quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	27.64	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.90	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
blood	UBERON:0000178	25.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.88	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8k16	ENSMUSG00000050603
mus_musculus	Or8k21	ENSMUSG00000075192
rattus_norvegicus	Or8k16	ENSRNOG00000084392
rattus_norvegicus	Or8k16b	ENSRNOG00000087401

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR9G4 (ENSG00000172457), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 8K5 — Q8NH50 (reviewed: Q8NH50)

Alternative names: Olfactory receptor OR11-174

All UniProt accessions (1): Q8NH50

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004058* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH50-F1	89.37	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 263

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11q12

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

296 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR8K5	PLEKHJ1	Q9NW61	478
OR8K5	TRIM48	Q8IWZ4	404
OR8K5	ZNF232	Q9UNY5	396
OR8K5	TRIM51	Q9BSJ1	393
OR8K5	ZNF804B	A4D1E1	375
OR8K5	APCDD1L	Q8NCL9	370
OR8K5	SLC45A4	Q5BKX6	356
OR8K5	ARK2C	Q6ZSG1	348
OR8K5	NYNRIN	Q9P2P1	327
OR8K5	RTL3	Q8N8U3	322
OR8K5	RPS6KC1	Q96S38	317
OR8K5	BEST3	Q8N1M1	305
OR8K5	TAAR5	O14804	302
OR8K5	SLC25A23	Q9BV35	301
OR8K5	NEK3	P51956	295

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NDL8, A6NF89, P0C617, P34983, P35898, P37067, P37069, P37070, P37072, Q60880, Q60886, Q8N127, Q8N162, Q8NG75, Q8NG78, Q8NGF7, Q8NGG0, Q8NGG3, Q8NGG5, Q8NGI9, Q8NGK9, Q8NGL1, Q8NGL3, Q8NGL4, Q8NGP2, Q8NGQ3, Q8NGS5, Q8NGS6, Q8NGV6, Q8NH48, Q8NH50, Q8NH51, Q8NH92, Q8NH93, Q8VEW2, Q8VEW6, Q8VF12, Q8VF13, Q8VF65, Q8VFD1

Diamond homologs: A6NCV1, A6NDL8, A6NF89, A6NIJ9, A6NJZ3, A6NL08, A6NL26, A6NM76, O43749, O76100, O95006, O95007, O95221, P0C626, P0C7N1, P0C7N5, P0DN81, P23266, P23267, P23269, P23272, P23274, P34984, P58173, P70526, Q13606, Q15619, Q15622, Q6IF82, Q6UXT6, Q7TQQ0, Q7Z3T1, Q8N148, Q8N628, Q8NG78, Q8NGA1, Q8NGC2, Q8NGC5, Q8NGE1, Q8NGE2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

178 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56160200:CCA:C	donor_gain	0.8500
11:56160145:G:C	donor_gain	0.7900
11:56160200:C:CT	donor_gain	0.7900
11:56160144:A:AC	donor_gain	0.7600
11:56160232:C:CA	donor_gain	0.7500
11:56159446:C:CC	acceptor_gain	0.7400
11:56160142:A:C	donor_gain	0.7000
11:56160255:AGG:A	donor_gain	0.7000
11:56159442:TAAG:T	acceptor_gain	0.6500
11:56159441:TTAAG:T	acceptor_gain	0.6400
11:56159445:GC:G	acceptor_loss	0.6400
11:56159446:C:CA	acceptor_loss	0.6400
11:56159447:T:G	acceptor_loss	0.6400
11:56160201:C:CT	donor_gain	0.6400
11:56160202:A:AC	donor_gain	0.6400
11:56160203:C:CC	donor_gain	0.6400
11:56160137:A:AC	donor_gain	0.6000
11:56160079:T:TG	acceptor_gain	0.5800
11:56159443:AAG:A	acceptor_gain	0.5700
11:56159444:AG:A	acceptor_gain	0.5600
11:56160099:A:AC	donor_gain	0.5600
11:56159477:C:CC	acceptor_gain	0.5400
11:56160187:G:C	donor_gain	0.5400
11:56160195:GCCCA:G	donor_loss	0.5200
11:56160197:CCACC:C	donor_loss	0.5200
11:56160198:CA:C	donor_loss	0.5200
11:56160199:A:C	donor_loss	0.5200
11:56160192:GTTGC:G	donor_loss	0.5100
11:56160194:TGC:T	donor_loss	0.5100
11:56160292:A:AC	donor_gain	0.5100

AlphaMissense

2035 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:56160282:G:C	F12L	0.779
11:56160282:G:T	F12L	0.779
11:56160284:A:G	F12L	0.779
11:56159814:G:C	F168L	0.749
11:56159814:G:T	F168L	0.749
11:56159816:A:G	F168L	0.749
11:56159826:A:C	F164L	0.746
11:56159826:A:T	F164L	0.746
11:56159828:A:G	F164L	0.746
11:56159787:A:C	F177L	0.699
11:56159787:A:T	F177L	0.699
11:56159789:A:G	F177L	0.699
11:56160135:A:C	F61L	0.693
11:56160135:A:T	F61L	0.693
11:56160137:A:G	F61L	0.693
11:56159565:G:C	F251L	0.631
11:56159565:G:T	F251L	0.631
11:56159567:A:G	F251L	0.631
11:56160225:G:C	F31L	0.613
11:56160225:G:T	F31L	0.613
11:56160227:A:G	F31L	0.613
11:56159487:A:C	F277L	0.609
11:56159487:A:T	F277L	0.609
11:56159489:A:G	F277L	0.609
11:56159547:G:C	F257L	0.603
11:56159547:G:T	F257L	0.603
11:56159549:A:G	F257L	0.603
11:56159604:G:C	F238L	0.594
11:56159604:G:T	F238L	0.594
11:56159606:A:G	F238L	0.594

dbSNP variants (sampled 300 via entrez): RS1000356154 (11:56161851 C>T), RS1001254018 (11:56159207 C>A), RS1002660606 (11:56160441 C>A,T), RS1002868369 (11:56160501 A>G), RS1003188515 (11:56159249 A>C,G), RS1005936809 (11:56161536 T>A), RS1006675681 (11:56159898 C>A,T), RS1006791962 (11:56161324 T>C), RS1007266078 (11:56161278 T>A,C), RS1007436141 (11:56161262 A>G), RS1009526509 (11:56160100 T>C), RS1010426782 (11:56159275 A>T), RS1010899202 (11:56162255 C>T), RS1011114652 (11:56159088 CAT>C), RS1011542100 (11:56159311 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation	1
Fulvestrant	decreases methylation, affects cotreatment	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.