OR9G1

Summary

OR9G1 (olfactory receptor family 9 subfamily G member 1, HGNC:15319) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 9G1 (Q8NH87). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390174 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_001005213

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15319
Approved symbol	OR9G1
Name	olfactory receptor family 9 subfamily G member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000174914
Ensembl biotype	protein_coding
Entrez	390174

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000642097

RefSeq mRNA: 1 — MANE Select: NM_001005213 NM_001005213

CCDS: CCDS31536

Canonical transcript exons

ENST00000573911 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 77.72.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.72	gold quality
sural nerve	UBERON:0015488	41.10	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
monocyte	CL:0000576	36.52	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
leukocyte	CL:0000738	35.71	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.41	gold quality
apex of heart	UBERON:0002098	34.69	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.83	gold quality
tonsil	UBERON:0002372	31.78	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
liver	UBERON:0002107	29.99	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.19	gold quality
urinary bladder	UBERON:0001255	28.48	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
placenta	UBERON:0001987	27.41	gold quality
primary visual cortex	UBERON:0002436	27.33	gold quality
blood	UBERON:0000178	26.98	gold quality
islet of Langerhans	UBERON:0000006	26.89	gold quality
adrenal tissue	UBERON:0018303	26.89	gold quality
cortex of kidney	UBERON:0001225	26.85	gold quality
calcaneal tendon	UBERON:0003701	26.52	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or9g20	ENSMUSG00000075209
rattus_norvegicus	Or9g20	ENSRNOG00000030662

Paralogs (33): TACR2 (ENSG00000075073), PROKR2 (ENSG00000101292), GPR50 (ENSG00000102195), TACR1 (ENSG00000115353), GPR75 (ENSG00000119737), PRLHR (ENSG00000119973), GPR83 (ENSG00000123901), MCHR1 (ENSG00000128285), OR11H1 (ENSG00000130538), MTNR1B (ENSG00000134640), MCHR2 (ENSG00000152034), NPY1R (ENSG00000164128), NPY5R (ENSG00000164129), MTNR1A (ENSG00000168412), PROKR1 (ENSG00000169618), TACR3 (ENSG00000169836), OR11H4 (ENSG00000176198), OR11H6 (ENSG00000176219), OR9A2 (ENSG00000179468), GPR88 (ENSG00000181656), GPR19 (ENSG00000183150), NPY2R (ENSG00000185149), OR11G2 (ENSG00000196832), NPY4R (ENSG00000204174), OR11A1 (ENSG00000204694), OR9A1P (ENSG00000237621), OR11H12 (ENSG00000257115), OR9A4 (ENSG00000258083), OR11H2 (ENSG00000258453), OR11H7 (ENSG00000258806), NPY4R2 (ENSG00000264717), OR10X1 (ENSG00000279111), OR51F1 (ENSG00000280021)

Protein

Protein identifiers

Olfactory receptor 9G1 — Q8NH87 (reviewed: Q8NH87)

Alternative names: Olfactory receptor 9G5, Olfactory receptor OR11-114

All UniProt accessions (1): Q8NH87

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005213* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (34 total): sequence variant 14, topological domain 8, transmembrane region 7, sequence conflict 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH87-F1	85.61	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, KMT2D_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

252 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR9G1	MROH8	Q9H579	626
OR9G1	GARIN5B	Q8N5Q1	571
OR9G1	FAM217A	Q8IXS0	507
OR9G1	RSPH10B2	B2RC85	447
OR9G1	CALHM4	Q5JW98	447
OR9G1	GOLGA6L1	Q8N7Z2	447
OR9G1	MROH9	Q5TGP6	444
OR9G1	LINC03042	Q6ZUL3	435
OR9G1	SHANK3	Q9BYB0	407
OR9G1	RSPH10B	P0C881	399
OR9G1	FAM81B	Q96LP2	397
OR9G1	CCDC81	Q6ZN84	394
OR9G1	MFSD6L	Q8IWD5	392
OR9G1	TMPRSS12	Q86WS5	371
OR9G1	METTL21C	Q5VZV1	360

IntAct

0 interactions, top by confidence:

BioGRID (1): OR9G1 (Affinity Capture-MS)

ESM2 similar proteins: O14581, O76099, O76100, P0C7N8, P34982, P35898, P37067, P37068, P37069, P37071, Q60879, Q60887, Q7TR96, Q8N349, Q8NG92, Q8NG95, Q8NG98, Q8NGA0, Q8NGA2, Q8NGG1, Q8NGL0, Q8NGP2, Q8NGQ6, Q8NGS1, Q8NGY9, Q8NGZ9, Q8NH87, Q8NHC8, Q8VEZ0, Q8VF65, Q8VF66, Q8VFD2, Q8VFV4, Q8VG06, Q8VG09, Q8VG42, Q8VG44, Q8VGI5, Q8WZ94, Q95157

Diamond homologs: A6NDH6, A6NKK0, A6NL08, B2RN74, O43749, O76002, O95006, O95007, O95221, O95222, P0C626, P0C628, P0C7N5, P0C7N8, P0DN80, P0DN82, P23266, P23267, P23270, P23274, P34984, P34986, P58173, P58181, P58182, Q13606, Q13607, Q5TZ20, Q60889, Q60890, Q60893, Q60894, Q6IFH4, Q7TR96, Q8N0Y5, Q8N127, Q8NG75, Q8NG94, Q8NGC1, Q8NGC5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

309 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56700590:T:A	acceptor_gain	0.7400
11:56700449:G:GT	donor_gain	0.7200
11:56701219:ACTGT:A	acceptor_gain	0.7100
11:56700457:C:G	donor_gain	0.6900
11:56700450:A:T	donor_gain	0.6600
11:56700573:T:A	acceptor_gain	0.6600
11:56700819:AGC:A	donor_gain	0.6400
11:56700499:GTG:G	donor_gain	0.6200
11:56700935:T:TA	acceptor_gain	0.6100
11:56700501:G:GA	donor_gain	0.6000
11:56700682:C:A	donor_gain	0.5800
11:56700560:T:G	donor_gain	0.5700
11:56701235:T:G	acceptor_gain	0.5700
11:56701223:T:TA	acceptor_gain	0.5600
11:56701247:T:TA	acceptor_gain	0.5600
11:56701270:G:GT	donor_gain	0.5600
11:56700536:A:AG	donor_gain	0.5500
11:56700616:A:AG	acceptor_gain	0.5500
11:56700838:G:GA	donor_gain	0.5500
11:56701263:GAA:G	donor_gain	0.5500
11:56700571:ACT:A	acceptor_gain	0.5400
11:56701224:G:GA	donor_gain	0.5300
11:56700978:GAT:G	donor_gain	0.5200
11:56700598:T:TA	acceptor_gain	0.5100
11:56700680:GTC:G	donor_gain	0.5100
11:56700961:G:GT	donor_gain	0.5100
11:56701137:C:CG	donor_gain	0.5000
11:56700498:TGTG:T	donor_loss	0.4900
11:56700500:TGG:T	donor_loss	0.4900
11:56700501:GGTAG:G	donor_loss	0.4900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001061593 (11:56698586 T>C), RS1001214740 (11:56701129 A>G), RS1001722577 (11:56701335 A>T), RS1002185402 (11:56701947 A>G), RS1002217199 (11:56701547 C>A,T), RS1002854885 (11:56699803 A>G), RS1003181729 (11:56697398 C>T), RS1003293568 (11:56700016 A>G), RS1003800201 (11:56702390 C>T), RS1004098244 (11:56702372 T>C,G), RS1004353787 (11:56699460 C>A,T), RS1005663733 (11:56697954 A>C), RS1005957576 (11:56697838 T>C,G), RS1006048388 (11:56698191 A>G,T), RS1006062249 (11:56698363 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000080_3	Hemostatic factors and hematological phenotypes	7.000000e-08
GCST005688_6	Idiopathic intracranial hypertension	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.