OR9G4

Summary

OR9G4 (olfactory receptor family 9 subfamily G member 4, HGNC:15322) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 9G4 (Q8NGQ1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 283189 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_001005284

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15322
Approved symbol	OR9G4
Name	olfactory receptor family 9 subfamily G member 4
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000172457
Ensembl biotype	protein_coding
Entrez	283189

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 2 protein_coding_CDS_not_defined, 2 protein_coding

ENST00000641505, ENST00000641581, ENST00000641668, ENST00000641980

RefSeq mRNA: 2 — MANE Select: NM_001005284 NM_001005284, NM_001390832

CCDS: CCDS31537

Canonical transcript exons

ENST00000575017 — 0 exons

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.43	gold quality
tonsil	UBERON:0002372	33.52	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.95	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
spleen	UBERON:0002106	30.82	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
monocyte	CL:0000576	28.61	gold quality
urinary bladder	UBERON:0001255	28.59	gold quality
leukocyte	CL:0000738	28.52	gold quality
liver	UBERON:0002107	28.29	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.36	gold quality
islet of Langerhans	UBERON:0000006	26.89	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.23	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.79	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.44	gold quality
endometrium	UBERON:0001295	24.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or9g4	ENSMUSG00000075211
rattus_norvegicus	Or9g4	ENSRNOG00000086035

Paralogs (96): OR5C1 (ENSG00000148215), OR5F1 (ENSG00000149133), OR8K1 (ENSG00000150261), OR5M9 (ENSG00000150269), OR14K1 (ENSG00000153230), OR8J3 (ENSG00000167822), OR5I1 (ENSG00000167825), OR5AU1 (ENSG00000169327), OR9K2 (ENSG00000170605), OR8B12 (ENSG00000170953), OR10H3 (ENSG00000171936), OR8I2 (ENSG00000172154), OR8U1 (ENSG00000172199), OR10V1 (ENSG00000172289), OR5A1 (ENSG00000172320), OR5A2 (ENSG00000172324), OR5B12 (ENSG00000172362), OR5B2 (ENSG00000172365), OR9I1 (ENSG00000172377), OR5AR1 (ENSG00000172459), OR5AP2 (ENSG00000172464), OR8J1 (ENSG00000172487), OR5B3 (ENSG00000172769), OR10W1 (ENSG00000172772), OR5M3 (ENSG00000174937), OR5J2 (ENSG00000174957), OR10H4 (ENSG00000176231), OR5AN1 (ENSG00000176495), OR14C36 (ENSG00000177174), OR6B3 (ENSG00000178586), OR10Q1 (ENSG00000180475), OR8G2P (ENSG00000181214), OR5AK2 (ENSG00000181273), OR5AK3P (ENSG00000181282), OR5M8 (ENSG00000181371), OR8D4 (ENSG00000181518), OR8H1 (ENSG00000181693), OR8K5 (ENSG00000181752), OR8H3 (ENSG00000181761), OR8H2 (ENSG00000181767)

Protein

Protein identifiers

Olfactory receptor 9G4 — Q8NGQ1 (reviewed: Q8NGQ1)

Alternative names: Olfactory receptor OR11-216

All UniProt accessions (1): A0A286YFA5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001005284, NP_001377761 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGQ1-F1	85.92	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 112–194

Glycosylation sites (1): 20

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), signal transduction (GO:0007165), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

214 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR9G4	YPEL4	Q96NS1	430
OR9G4	GNG8	Q9UK08	410
OR9G4	THSD7B	Q9C0I4	371
OR9G4	ANO2	Q9NQ90	363
OR9G4	CNGA2	Q16280	362
OR9G4	NLRP11	P59045	358
OR9G4	GNG13	Q9P2W3	325
OR9G4	LAIR2	Q6ISS4	317
OR9G4	GNAL	P38405	315
OR9G4	PGLS	O95336	301
OR9G4	GNGT2	O14610	272
OR9G4	ADCY3	O60266	269
OR9G4	ECI2	O75521	267
OR9G4	ATP6V0C	P27449	259
OR9G4	CXXC5	Q7LFL8	252

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NL26, O14581, O76100, O95006, P34986, P37068, P37070, P37071, P58173, Q5TZ20, Q60890, Q60893, Q6IEU7, Q8N146, Q8NGA1, Q8NGE9, Q8NGG1, Q8NGG4, Q8NGI9, Q8NGL2, Q8NGP8, Q8NGQ1, Q8NGQ6, Q8NGS0, Q8NGZ4, Q8NGZ9, Q8NH01, Q8NH04, Q8NHC8, Q8VEW5, Q8VEZ0, Q8VF65, Q8VF66, Q8VF76, Q8VFD2, Q8VFL9, Q8VFM9, Q8VFX2, Q8VG02, Q8VG05

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P58180, Q13606, Q15615, Q60878, Q60881, Q60888, Q60893, Q6IEV9, Q6IEY1, Q6IF82, Q6UXT6, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGA1, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD3, Q8NGD4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

257 predictions. Top by Δscore:

Variant	Effect	Δscore
11:56743644:T:TA	donor_gain	0.9100
11:56743681:C:CA	donor_gain	0.8700
11:56743762:T:TA	donor_gain	0.7400
11:56743098:C:CT	acceptor_gain	0.7200
11:56743594:G:C	donor_gain	0.6600
11:56742891:CAGG:C	acceptor_gain	0.6500
11:56743105:A:C	acceptor_gain	0.6400
11:56743215:CAA:C	acceptor_gain	0.6200
11:56743680:T:A	donor_gain	0.6200
11:56742997:A:C	donor_gain	0.6000
11:56743099:A:T	acceptor_gain	0.6000
11:56743216:A:T	acceptor_gain	0.6000
11:56743068:T:TA	donor_gain	0.5900
11:56743098:C:T	acceptor_gain	0.5900
11:56743113:A:C	acceptor_gain	0.5900
11:56743724:A:C	donor_gain	0.5900
11:56743755:T:A	donor_gain	0.5800
11:56742895:C:CC	acceptor_gain	0.5700
11:56742994:A:C	acceptor_gain	0.5600
11:56743229:C:CT	acceptor_gain	0.5500
11:56743113:A:AC	acceptor_gain	0.5400
11:56743022:TG:T	donor_gain	0.5100
11:56743105:A:AC	acceptor_gain	0.5000
11:56742983:GCCTT:G	acceptor_gain	0.4900
11:56742995:TAA:T	donor_gain	0.4900
11:56742996:AAA:A	donor_gain	0.4900
11:56743223:G:GC	acceptor_gain	0.4900
11:56743501:T:C	donor_gain	0.4800
11:56743593:A:AC	donor_gain	0.4800
11:56742986:T:C	acceptor_gain	0.4700

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000666467 (11:56750597 C>A,T), RS1000720385 (11:56744814 T>C), RS1000724504 (11:56750286 A>G), RS1000750612 (11:56747725 A>G), RS1001209245 (11:56747934 A>G), RS1001434843 (11:56747067 C>G,T), RS1001536389 (11:56747364 A>G), RS1001585256 (11:56747643 T>C), RS1001677459 (11:56741781 T>C), RS1003261054 (11:56746248 C>A,G), RS1004615010 (11:56741182 T>C,G), RS1004703385 (11:56745644 C>T), RS1004757148 (11:56745892 C>T), RS1004977157 (11:56746771 A>G), RS1005271632 (11:56748817 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000080_3	Hemostatic factors and hematological phenotypes	7.000000e-08
GCST002942_10	Percentage gas trapping	7.000000e-07
GCST010242_400	HDL cholesterol levels	7.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0007628	gas trapping measurement
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Malathion	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Sodium Selenite	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.