ORC3

Summary

ORC3 (origin recognition complex subunit 3, HGNC:8489) is a protein-coding gene on chromosome 6q15, encoding Origin recognition complex subunit 3 (Q9UBD5). Component of the origin recognition complex (ORC) that binds origins of replication. It is a selective cancer dependency (DepMap: 42.5% of cell lines).

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

Source: NCBI Gene 23595 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 136 total — 2 likely-pathogenic
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 42.5% of screened cell lines
• MANE Select transcript: NM_012381

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8489
Approved symbol	ORC3
Name	origin recognition complex subunit 3
Location	6q15
Locus type	gene with protein product
Status	Approved
Aliases	IMAGE50150, LATHEO
Ensembl gene	ENSG00000135336
Ensembl biotype	protein_coding
OMIM	604972
Entrez	23595

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 24 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000257789, ENST00000392844, ENST00000468486, ENST00000478028, ENST00000508875, ENST00000546266, ENST00000681069, ENST00000850561, ENST00000891527, ENST00000891528, ENST00000891529, ENST00000891530, ENST00000891531, ENST00000891532, ENST00000891533, ENST00000891534, ENST00000891535, ENST00000891536, ENST00000911372, ENST00000911373, ENST00000911374, ENST00000954635, ENST00000954636, ENST00000954637, ENST00000954638, ENST00000954639, ENST00000954640

RefSeq mRNA: 3 — MANE Select: NM_012381 NM_001197259, NM_012381, NM_181837

CCDS: CCDS43486, CCDS5012, CCDS56440

Canonical transcript exons

ENST00000392844 — 20 exons

Exon	Start	End
ENSE00000918674	87665754	87665833
ENSE00000918675	87664743	87664859
ENSE00000918676	87663003	87663144
ENSE00000918680	87636407	87636486
ENSE00000918681	87634845	87634961
ENSE00000918682	87621950	87622013
ENSE00000918683	87621354	87621487
ENSE00000918684	87616314	87616427
ENSE00000918685	87612089	87612248
ENSE00000918686	87609096	87609229
ENSE00001513332	87656906	87656982
ENSE00001855575	87667018	87667451
ENSE00003546411	87594353	87594407
ENSE00003575034	87657921	87658018
ENSE00003614651	87605917	87606021
ENSE00003630477	87603384	87603528
ENSE00003644874	87607673	87607824
ENSE00003652621	87653116	87653249
ENSE00003676139	87601784	87601881
ENSE00004282117	87590135	87590192

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 93.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 31.1069 / max 731.9796, expressed in 1796 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
68841	31.1069	1796

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
triceps brachii	UBERON:0001509	93.58	gold quality
calcaneal tendon	UBERON:0003701	92.72	gold quality
adrenal tissue	UBERON:0018303	92.35	gold quality
ventricular zone	UBERON:0003053	91.35	gold quality
gluteal muscle	UBERON:0002000	91.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.90	gold quality
embryo	UBERON:0000922	90.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.29	gold quality
ganglionic eminence	UBERON:0004023	90.29	gold quality
right adrenal gland	UBERON:0001233	90.03	gold quality
right adrenal gland cortex	UBERON:0035827	89.96	gold quality
biceps brachii	UBERON:0001507	89.68	gold quality
left adrenal gland	UBERON:0001234	89.24	gold quality
islet of Langerhans	UBERON:0000006	89.16	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	89.04	gold quality
sperm	CL:0000019	89.00	gold quality
adrenal gland	UBERON:0002369	88.93	gold quality
right uterine tube	UBERON:0001302	88.79	gold quality
deltoid	UBERON:0001476	88.76	gold quality
left adrenal gland cortex	UBERON:0035825	88.71	gold quality
vastus lateralis	UBERON:0001379	88.66	silver quality
male germ cell	CL:0000015	88.55	gold quality
adrenal cortex	UBERON:0001235	88.54	gold quality
pons	UBERON:0000988	88.33	gold quality
myocardium	UBERON:0002349	88.20	gold quality
quadriceps femoris	UBERON:0001377	88.10	silver quality
muscle of leg	UBERON:0001383	87.98	gold quality
gastrocnemius	UBERON:0001388	87.96	gold quality
muscle organ	UBERON:0001630	87.96	gold quality
skeletal muscle organ	UBERON:0014892	87.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting ORC3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-8054	99.48	70.81	2084
HSA-MIR-508-5P	99.41	64.25	1248
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-8066	99.05	68.66	1532
HSA-MIR-3908	98.75	67.31	1160
HSA-MIR-3145-5P	98.57	67.83	900
HSA-MIR-5572	98.55	65.84	970
HSA-MIR-3680-5P	98.06	66.20	394
HSA-MIR-4294	97.86	65.72	1110
HSA-MIR-3198	97.84	65.64	579
HSA-MIR-4309	97.84	65.45	588
HSA-MIR-6514-3P	97.52	66.50	808
HSA-MIR-6855-5P	97.51	66.03	830
HSA-MIR-4798-3P	95.89	63.63	104
HSA-MIR-191-5P	95.88	67.82	171

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 42.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• Functional studies of the Drosophila homolog (PMID:10402192)
• Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. (PMID:15910003)
• Lifetime severity of positive symptoms was significantly (P = 2.50 x 10(-5)) associated with a SNP within the origin recognition complex subunit 3-like (ORC3L) gene, a gene implicated in synaptic plasticity. (PMID:18628273)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	orc3	ENSDARG00000008805
mus_musculus	Orc3	ENSMUSG00000040044
rattus_norvegicus	Orc3	ENSRNOG00000008314
drosophila_melanogaster	Orc3	FBGN0005654

Protein

Protein identifiers

Origin recognition complex subunit 3 — Q9UBD5 (reviewed: Q9UBD5)

Alternative names: Origin recognition complex subunit Latheo

All UniProt accessions (2): Q9UBD5, U3KQL3

UniProt curated annotations — full annotation on UniProt →

Function. Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Subunit / interactions. Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.

Subcellular location. Nucleus. Chromosome.

Post-translational modifications. Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle.

Similarity. Belongs to the ORC3 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9UBD5-1	1	yes
Q9UBD5-2	2
Q9UBD5-3	3

RefSeq proteins (3): NP_001184188, NP_036513, NP_862820 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020795	ORC3	Family
IPR040855	ORC_WH_C	Domain
IPR045663	ORC3_ins	Domain
IPR045667	ORC3_N	Domain

Pfam: PF07034, PF18137, PF19675

Enzyme classification (BRENDA):

• EC 3.6.4.B8 — (BRENDA: organisms, substrates, inhibitors, Km, kcat entries)

UniProt features (66 total): helix 31, strand 9, sequence variant 8, turn 7, sequence conflict 6, modified residue 2, splice variant 2, chain 1

Structure

Experimental structures (PDB)

15 structures.

PDB	Method	Resolution (Å)
7JPO	ELECTRON MICROSCOPY	3.2
7JPQ	ELECTRON MICROSCOPY	3.5
8S0D	ELECTRON MICROSCOPY	3.6
7JPP	ELECTRON MICROSCOPY	3.7
7CTE	ELECTRON MICROSCOPY	3.8
8S0E	ELECTRON MICROSCOPY	3.8
7JPR	ELECTRON MICROSCOPY	4
8S0C	ELECTRON MICROSCOPY	4
8S0F	ELECTRON MICROSCOPY	4.1
7JPS	ELECTRON MICROSCOPY	4.4
7CTF	ELECTRON MICROSCOPY	4.8
7CTG	ELECTRON MICROSCOPY	5
5UJ8	X-RAY DIFFRACTION	6
8RWV	ELECTRON MICROSCOPY	6.68
5UJM	ELECTRON MICROSCOPY	18

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UBD5-F1	80.51	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 23, 516

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation
R-HSA-176187	Activation of ATR in response to replication stress
R-HSA-68616	Assembly of the ORC complex at the origin of replication
R-HSA-68689	CDC6 association with the ORC:origin complex
R-HSA-68867	Assembly of the pre-replicative complex
R-HSA-68949	Orc1 removal from chromatin
R-HSA-68962	Activation of the pre-replicative complex

MSigDB gene sets: 139 (showing top): chr6q15, REACTOME_DNA_REPLICATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS, RIZKI_TUMOR_INVASIVENESS_3D_DN, PATIL_LIVER_CANCER, GOBP_NEURAL_PRECURSOR_CELL_PROLIFERATION, MODULE_239, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, DODD_NASOPHARYNGEAL_CARCINOMA_UP, FISCHER_DREAM_TARGETS, BECKER_TAMOXIFEN_RESISTANCE_DN, ACEVEDO_LIVER_CANCER_UP, GOBP_DNA_REPLICATION

GO Biological Process (5): DNA replication (GO:0006260), DNA replication initiation (GO:0006270), regulation of DNA replication (GO:0006275), glial cell proliferation (GO:0014009), neural precursor cell proliferation (GO:0061351)

GO Molecular Function (3): DNA replication origin binding (GO:0003688), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (10): chromosome, telomeric region (GO:0000781), chromatin (GO:0000785), origin recognition complex (GO:0000808), nucleus (GO:0005634), nucleoplasm (GO:0005654), nuclear pre-replicative complex (GO:0005656), nuclear origin of replication recognition complex (GO:0005664), nuclear body (GO:0016604), DNA replication preinitiation complex (GO:0031261), chromosome (GO:0005694)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Assembly of the pre-replicative complex	2
DNA Replication Pre-Initiation	2
E2F mediated regulation of DNA replication	1
G2/M Checkpoints	1
Switching of origins to a post-replicative state	1
G1/S Transition	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nucleoplasm	3
nuclear protein-containing complex	3
DNA metabolic process	2
cell population proliferation	2
chromosome	2
cellular anatomical structure	2
origin recognition complex	2
intracellular membraneless organelle	2
DNA biosynthetic process	1
DNA-templated DNA replication	1
DNA replication	1
regulation of DNA metabolic process	1
gliogenesis	1
sequence-specific double-stranded DNA binding	1
nucleic acid binding	1
binding	1
chromosomal region	1
protein-containing complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
pre-replicative complex	1
MCM complex	1
nuclear chromosome	1
nuclear pre-replicative complex	1
protein-DNA complex	1

Protein interactions and networks

STRING

1659 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ORC3	ORC5	O43913	997
ORC3	ORC4	O43929	996
ORC3	ORC6	Q9Y5N6	989
ORC3	ORC2	Q13416	953
ORC3	CDT1	Q9H211	821
ORC3	MCM3	P25205	813
ORC3	CDC6	Q99741	775
ORC3	LRWD1	Q9UFC0	732
ORC3	MCM5	P33992	711
ORC3	CDC45	O75419	709
ORC3	MCM4	P33991	709
ORC3	DBF4	Q9UBU7	703
ORC3	ORC1	Q13415	680
ORC3	MCM6	Q14566	680
ORC3	SMC3	Q9UQE7	630

IntAct

93 interactions, top by confidence:

A	B	Type	Score
MCMBP	MCM3	psi-mi:“MI:0914”(association)	0.890
ORC1	ORC5	psi-mi:“MI:0915”(physical association)	0.870
ORC1	ORC5	psi-mi:“MI:0914”(association)	0.870
ORC1	ORC3	psi-mi:“MI:0407”(direct interaction)	0.820
ORC2	ORC5	psi-mi:“MI:0914”(association)	0.810
ORC2	ORC5	psi-mi:“MI:0915”(physical association)	0.810
ORC2	ORC4	psi-mi:“MI:0914”(association)	0.810
ORC4	ORC2	psi-mi:“MI:0914”(association)	0.810
ORC2	ORC3	psi-mi:“MI:0915”(physical association)	0.700
ORC6	ORC3	psi-mi:“MI:0407”(direct interaction)	0.660
ORC6	ORC3	psi-mi:“MI:0915”(physical association)	0.660
ORC3	ORC5	psi-mi:“MI:0407”(direct interaction)	0.590
ORC4	ORC3	psi-mi:“MI:0407”(direct interaction)	0.590
ORC3	ORC5	psi-mi:“MI:0914”(association)	0.590

BioGRID (165): ORC3 (Protein-peptide), ORC3 (Protein-peptide), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC2 (Co-fractionation), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS), ORC3 (Affinity Capture-MS)

ESM2 similar proteins: A6NES4, A7E2Y6, A8C752, A8C754, A8C756, B0I564, D3Z750, E0CZ22, E1BP36, E9Q2M9, O35821, O43156, O70576, P50851, Q0V9L1, Q15021, Q15051, Q32PJ3, Q4R180, Q5DJU3, Q5TGP6, Q642P2, Q66H56, Q692V3, Q6DCF2, Q6NXR4, Q6P2S7, Q6P3V7, Q6YHU6, Q6ZS30, Q6ZS81, Q6ZUA9, Q7M6Y6, Q7TPV4, Q7Z745, Q8BGV4, Q8BP00, Q8C3S2, Q8IYW2, Q8K368

Diamond homologs: Q32PJ3, Q4R180, Q55BR6, Q5DJU3, Q9JK30, Q9UBD5

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
ORC3	“form complex”	ORC	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 69 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of the pre-replicative complex	12	83.3×	1e-18
Activation of ATR in response to replication stress	12	76.7×	2e-18
DNA Replication Pre-Initiation	6	40.5×	2e-07
Synthesis of DNA	6	38.4×	2e-07
Orc1 removal from chromatin	10	38.0×	8e-12
DNA Replication	7	35.4×	3e-08
G1/S Transition	7	34.7×	3e-08
Switching of origins to a post-replicative state	5	32.0×	8e-06

GO biological processes:

GO term	Partners	Fold	FDR
DNA replication initiation	13	137.5×	3e-23
DNA replication	7	19.6×	1e-05
DNA damage response	7	6.3×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

136 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	2
Uncertain significance	100
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
3068442	NM_012381.4(ORC3):c.647T>A (p.Val216Asp)	Likely pathogenic
3068448	NM_012381.4(ORC3):c.873+4A>G	Likely pathogenic

SpliceAI

3968 predictions. Top by Δscore:

Variant	Effect	Δscore
6:87594349:ATAG:A	acceptor_gain	1.0000
6:87594351:AG:A	acceptor_gain	1.0000
6:87594352:GG:G	acceptor_gain	1.0000
6:87601781:TA:T	acceptor_loss	1.0000
6:87601782:A:AG	acceptor_gain	1.0000
6:87601782:AGAG:A	acceptor_gain	1.0000
6:87601783:G:GA	acceptor_gain	1.0000
6:87601783:GA:G	acceptor_gain	1.0000
6:87601783:GAGG:G	acceptor_gain	1.0000
6:87601783:GAGGA:G	acceptor_gain	1.0000
6:87603382:A:AG	acceptor_gain	1.0000
6:87603383:G:GG	acceptor_gain	1.0000
6:87603539:G:GG	donor_gain	1.0000
6:87609083:A:AG	acceptor_gain	1.0000
6:87609083:AAT:A	acceptor_gain	1.0000
6:87609083:AATG:A	acceptor_gain	1.0000
6:87609084:A:G	acceptor_gain	1.0000
6:87609085:T:TA	acceptor_gain	1.0000
6:87621485:G:GT	donor_gain	1.0000
6:87621925:AT:A	acceptor_gain	1.0000
6:87621930:T:TA	acceptor_gain	1.0000
6:87621931:G:A	acceptor_gain	1.0000
6:87654340:G:GT	donor_gain	1.0000
6:87654354:GCAC:G	donor_gain	1.0000
6:87657919:A:AG	acceptor_gain	1.0000
6:87657920:G:GA	acceptor_gain	1.0000
6:87662979:T:G	acceptor_gain	1.0000
6:87664741:A:AG	acceptor_gain	1.0000
6:87664742:G:GG	acceptor_gain	1.0000
6:87665749:AAAAG:A	acceptor_gain	1.0000

AlphaMissense

4700 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:87664851:T:A	W648R	0.998
6:87664851:T:C	W648R	0.998
6:87667047:T:C	L687P	0.997
6:87664813:T:C	L635P	0.996
6:87667034:G:C	A683P	0.996
6:87663119:T:C	L603P	0.995
6:87667038:T:A	V684D	0.993
6:87667059:G:A	G691E	0.993
6:87667102:A:C	R705S	0.993
6:87667102:A:T	R705S	0.993
6:87621390:A:C	S342R	0.991
6:87621392:T:A	S342R	0.991
6:87621392:T:G	S342R	0.991
6:87665754:G:C	A651P	0.991
6:87667025:T:C	F680L	0.991
6:87667026:T:C	F680S	0.991
6:87667027:T:A	F680L	0.991
6:87667027:T:G	F680L	0.991
6:87667065:T:A	I693K	0.991
6:87603514:C:A	A103D	0.990
6:87664819:T:C	L637P	0.990
6:87665757:T:C	F652L	0.990
6:87665759:T:A	F652L	0.990
6:87665759:T:G	F652L	0.990
6:87663116:C:A	A602E	0.989
6:87664843:T:C	L645P	0.989
6:87667101:G:C	R705T	0.989
6:87663115:G:C	A602P	0.988
6:87664815:C:G	H636D	0.988
6:87667104:T:C	L706P	0.988

dbSNP variants (sampled 300 via entrez): RS1000007823 (6:87660876 T>G), RS1000009061 (6:87604799 A>G), RS1000033201 (6:87603321 C>T), RS1000054225 (6:87648301 C>T), RS1000058665 (6:87592965 C>T), RS1000076356 (6:87656409 G>A), RS1000122511 (6:87646982 A>G,T), RS1000166157 (6:87598516 T>C), RS1000209377 (6:87642224 T>G), RS1000240537 (6:87641955 A>G,T), RS1000263057 (6:87610443 A>C,G), RS1000323799 (6:87646226 T>C), RS1000368857 (6:87637027 A>G), RS1000428492 (6:87648663 A>G), RS1000430516 (6:87590091 C>T)

Disease associations

OMIM: gene MIM:604972 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001762_245	Obesity-related traits	4.000000e-06
GCST001762_760	Obesity-related traits	4.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005106	body composition measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067165 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
Cyclosporine	increases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
2,2’-methylenebis(4-methyl-6-tert-butylphenol)	affects expression, affects response to substance	1
beta-lapachone	decreases expression	1
cobaltous chloride	increases expression	1
beta-methylcholine	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
azoxystrobin	decreases expression	1
CGP 52608	affects binding, increases reaction	1
deguelin	decreases expression	1
abrine	decreases expression	1
pyrachlostrobin	decreases expression	1
bisphenol S	increases methylation	1
picoxystrobin	decreases expression	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Cannabidiol	increases expression	1
Cisplatin	increases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases methylation	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652944	Binding	Binding affinity to human ORC3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.