OSBPL11

Summary

OSBPL11 (oxysterol binding protein like 11, HGNC:16397) is a protein-coding gene on chromosome 3q21.2, encoding Oxysterol-binding protein-related protein 11 (Q9BXB4). Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage.

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.

Source: NCBI Gene 114885 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 105 total
• MANE Select transcript: NM_022776

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16397
Approved symbol	OSBPL11
Name	oxysterol binding protein like 11
Location	3q21.2
Locus type	gene with protein product
Status	Approved
Aliases	ORP-11, ORP11, FLJ13012, FLJ13164
Ensembl gene	ENSG00000144909
Ensembl biotype	protein_coding
OMIM	606739
Entrez	114885

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 protein_coding

ENST00000296220, ENST00000910154, ENST00000910155, ENST00000910156, ENST00000910157, ENST00000931704, ENST00000931705, ENST00000931706, ENST00000953165

RefSeq mRNA: 1 — MANE Select: NM_022776 NM_022776

CCDS: CCDS3033

Canonical transcript exons

ENST00000296220 — 13 exons

Exon	Start	End
ENSE00000967853	125579865	125580040
ENSE00000967854	125578960	125579039
ENSE00000967855	125576189	125576365
ENSE00000967856	125567394	125567595
ENSE00001079273	125582910	125582978
ENSE00001079275	125560379	125560519
ENSE00001079276	125552181	125552679
ENSE00001079279	125547406	125547592
ENSE00001079281	125538451	125538633
ENSE00001079283	125531861	125532014
ENSE00001079287	125563698	125563843
ENSE00001154393	125594637	125595497
ENSE00001942711	125528858	125530580

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 95.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.6303 / max 103.9363, expressed in 1716 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44307	3.3579	1391
44304	2.1564	986
44305	1.8159	853
44306	1.4690	928
44303	0.8311	495

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
biceps brachii	UBERON:0001507	95.86	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	95.18	gold quality
vastus lateralis	UBERON:0001379	94.72	gold quality
diaphragm	UBERON:0001103	94.49	gold quality
quadriceps femoris	UBERON:0001377	94.12	gold quality
deltoid	UBERON:0001476	93.39	gold quality
gastrocnemius	UBERON:0001388	93.18	gold quality
skeletal muscle tissue	UBERON:0001134	93.12	gold quality
muscle organ	UBERON:0001630	92.91	gold quality
skeletal muscle organ	UBERON:0014892	92.91	gold quality
muscle of leg	UBERON:0001383	92.50	gold quality
monocyte	CL:0000576	92.20	gold quality
mononuclear cell	CL:0000842	92.04	gold quality
leukocyte	CL:0000738	91.73	gold quality
tibialis anterior	UBERON:0001385	91.73	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	91.54	gold quality
secondary oocyte	CL:0000655	91.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	91.19	gold quality
cranial nerve II	UBERON:0000941	90.95	gold quality
gluteal muscle	UBERON:0002000	90.39	gold quality
triceps brachii	UBERON:0001509	89.31	gold quality
muscle tissue	UBERON:0002385	89.00	gold quality
medial globus pallidus	UBERON:0002477	88.11	gold quality
choroid plexus epithelium	UBERON:0003911	87.89	gold quality
blood	UBERON:0000178	87.42	gold quality
globus pallidus	UBERON:0001875	86.95	gold quality
visceral pleura	UBERON:0002401	86.57	gold quality
body of tongue	UBERON:0011876	86.01	gold quality
oocyte	CL:0000023	85.86	gold quality
palpebral conjunctiva	UBERON:0001812	85.46	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.85
E-MTAB-6142	no	60.46

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

190 targeting OSBPL11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-548AA	99.96	70.64	3753

Literature-anchored findings (GeneRIF, showing 4)

• The OSBPL11 gene is involved in cholesterol and glucose metabolism in obese individuals. (PMID:19325544)
• The results identify ORP11 as an OSBP homologue distributing at the Golgi-LE interface and define the ORP9-ORP11 dimer as a functional unit that may act as an intracellular lipid sensor or transporter. (PMID:20599956)
• ORP8 overexpression resulted in reduced expression of the aP2 mRNA, while down-regulation of adiponectin and aP2 was observed in ORP11 silenced cells. ORP8 overexpression or silencing of ORP11 markedly decreased cellular triglyceride storage. (PMID:23028956)
• OSBPL11 is down-regulated and may be a potential indicator for hepatocellular carcinoma. (PMID:31173207)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	osbpl11	ENSDARG00000076328
mus_musculus	Osbpl11	ENSMUSG00000022807
rattus_norvegicus	Osbpl11	ENSRNOG00000001782
drosophila_melanogaster	CG3860	FBGN0034951
caenorhabditis_elegans		WBGENE00008832

Paralogs (11): OSBPL7 (ENSG00000006025), OSBPL5 (ENSG00000021762), OSBPL3 (ENSG00000070882), OSBPL6 (ENSG00000079156), OSBPL8 (ENSG00000091039), OSBP (ENSG00000110048), OSBPL9 (ENSG00000117859), OSBPL2 (ENSG00000130703), OSBPL1A (ENSG00000141447), OSBPL10 (ENSG00000144645), OSBP2 (ENSG00000184792)

Protein

Protein identifiers

Oxysterol-binding protein-related protein 11 — Q9BXB4 (reviewed: Q9BXB4)

All UniProt accessions (2): Q9BXB4, A0A140VJQ6

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex.

Subunit / interactions. Heterodimer with OSBPL9.

Subcellular location. Late endosome membrane. Golgi apparatus. trans-Golgi network membrane.

Tissue specificity. Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin. Present at low levels in subcutaneous and visceral adipose tissue (at protein level).

Domain organisation. The PH domain binds phosphoinositides.

Similarity. Belongs to the OSBP family.

RefSeq proteins (1): NP_073613* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000648	Oxysterol-bd	Family
IPR001849	PH_domain	Domain
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR018494	Oxysterol-bd_CS	Conserved_site
IPR037239	OSBP_sf	Homologous_superfamily

Pfam: PF00169, PF01237

Catalyzed reactions (Rhea), 1 shown:

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) (RHEA:81667)

UniProt features (32 total): modified residue 10, strand 9, region of interest 3, sequence variant 2, turn 2, helix 2, compositionally biased region 2, chain 1, domain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2D9X	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BXB4-F1	75.26	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 62, 172, 174, 177, 181, 184, 189, 1, 15, 27

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9013407	RHOH GTPase cycle

MSigDB gene sets: 0 (showing top):

GO Biological Process (4): fat cell differentiation (GO:0045444), triglyceride homeostasis (GO:0070328), intermembrane lipid transfer (GO:0120009), lipid transport (GO:0006869)

GO Molecular Function (3): sterol binding (GO:0032934), protein binding (GO:0005515), lipid binding (GO:0008289)

GO Cellular Component (7): nucleoplasm (GO:0005654), Golgi apparatus (GO:0005794), cytosol (GO:0005829), membrane (GO:0016020), late endosome membrane (GO:0031902), protein-containing complex (GO:0032991), endosome (GO:0005768)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
binding	2
cytoplasm	2
endomembrane system	2
cell differentiation	1
acylglycerol homeostasis	1
lipid transport	1
membrane organization	1
transport	1
lipid localization	1
steroid binding	1
nuclear lumen	1
intracellular membrane-bounded organelle	1
late endosome	1
endosome membrane	1
cellular_component	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

1178 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OSBPL11	PLEK2	Q9NYT0	616
OSBPL11	PLEK	P08567	605
OSBPL11	OSBP	P22059	472
OSBPL11	OSBP2	Q969R2	464
OSBPL11	NME6	O75414	461
OSBPL11	VAPA	Q9P0L0	454
OSBPL11	LRRC30	A6NM36	409
OSBPL11	PI4KB	P78405	397
OSBPL11	PLXNB1	O43157	391
OSBPL11	LRRC20	Q8TCA0	384
OSBPL11	DHX30	Q7L2E3	368
OSBPL11	VAPB	O95292	367
OSBPL11	PTPN23	Q9H3S7	365
OSBPL11	OSBPL3	Q9H4L5	355
OSBPL11	OSBPL7	Q9BZF2	354

IntAct

73 interactions, top by confidence:

A	B	Type	Score
OSBPL9	VAPB	psi-mi:“MI:0914”(association)	0.790
OSBPL9	OSBPL11	psi-mi:“MI:0915”(physical association)	0.780
OSBPL11	OSBPL9	psi-mi:“MI:0915”(physical association)	0.780
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
OSBPL11	VAPB	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
VAPA	PITPNM1	psi-mi:“MI:0914”(association)	0.640
CFAP36	SNTB2	psi-mi:“MI:0914”(association)	0.620
RAB11A	CHML	psi-mi:“MI:2364”(proximity)	0.610
	OSBPL11	psi-mi:“MI:0407”(direct interaction)	0.590
IGF1R	PIK3R2	psi-mi:“MI:2364”(proximity)	0.590
PLVAP	SMPD2	psi-mi:“MI:0914”(association)	0.530
ALOX5	DDHD2	psi-mi:“MI:0914”(association)	0.530
DNAJA1	HERC2	psi-mi:“MI:0914”(association)	0.530
TPCN2	AP3B1	psi-mi:“MI:0914”(association)	0.530
SKP2	DPYSL4	psi-mi:“MI:0914”(association)	0.530
DNAJA1	DNAJA2	psi-mi:“MI:0914”(association)	0.530

BioGRID (146): OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Reconstituted Complex), OSBPL11 (Proximity Label-MS), OSBPL11 (Proximity Label-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS), OSBPL11 (Affinity Capture-MS)

ESM2 similar proteins: A0A075QQ08, A0A1D8EJF9, A0A1U8F5V2, A0A1U8GR65, A0A2J6L8Y7, A0A3Q7FGP1, A0A3Q7I7R4, A0A445AGS0, A7KWF8, C6ZJZ3, C7SG33, D3UW26, K0P2S0, M1J8U6, M1JJT8, O23252, O60573, O77210, O81481, O81482, P0DXI0, P0DXI5, P10687, P10894, P29557, P48598, P48599, P48600, Q03389, Q0GRC4, Q3UTA9, Q4QXS7, Q4VQY1, Q4VQY3, Q66UV4, Q66WU1, Q681Q7, Q8BMB3, Q8CI95, Q8K394

Diamond homologs: A0A2Z4HQ03, A2A8Z1, B9EJ86, O43021, O74178, O80866, P0C199, P35844, P38755, Q02201, Q0IJ05, Q54NM4, Q5M7Y0, Q5R6M6, Q5R9W4, Q6NRZ4, Q6P3Q6, Q6VVX2, Q86KG4, Q8BX94, Q8CI95, Q96SU4, Q9BXB4, Q9BXB5, Q9BZF1, Q9EQG9, Q9ER64, Q9GKI7, Q9H0X9, Q9H1P3, Q9UUA1, Q9UW21, Q9UW25, Q9Y5P4, S4R1M9, O94512, Q12451, Q54PS9, Q8S8P9, Q9SVZ9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

105 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	90
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1892 predictions. Top by Δscore:

Variant	Effect	Δscore
3:125531855:GCATA:G	donor_loss	1.0000
3:125531856:CATAC:C	donor_loss	1.0000
3:125531857:ATACC:A	donor_loss	1.0000
3:125531860:C:G	donor_loss	1.0000
3:125531860:CCT:C	donor_gain	1.0000
3:125531862:T:TA	donor_gain	1.0000
3:125531894:G:A	donor_gain	1.0000
3:125532010:ATCGC:A	acceptor_gain	1.0000
3:125532011:TCGC:T	acceptor_gain	1.0000
3:125532012:CGC:C	acceptor_gain	1.0000
3:125532012:CGCC:C	acceptor_gain	1.0000
3:125532013:GC:G	acceptor_gain	1.0000
3:125532013:GCC:G	acceptor_loss	1.0000
3:125532014:CC:C	acceptor_gain	1.0000
3:125532015:C:CC	acceptor_gain	1.0000
3:125532016:T:G	acceptor_loss	1.0000
3:125532023:C:CT	acceptor_gain	1.0000
3:125532023:C:T	acceptor_gain	1.0000
3:125532024:A:T	acceptor_gain	1.0000
3:125538446:CATA:C	donor_loss	1.0000
3:125538447:ATACC:A	donor_loss	1.0000
3:125538448:TACC:T	donor_loss	1.0000
3:125538449:ACCTG:A	donor_loss	1.0000
3:125538450:C:CG	donor_loss	1.0000
3:125538629:TAACC:T	acceptor_gain	1.0000
3:125538631:ACC:A	acceptor_gain	1.0000
3:125538632:CC:C	acceptor_gain	1.0000
3:125538632:CCC:C	acceptor_gain	1.0000
3:125538633:CC:C	acceptor_gain	1.0000
3:125538634:C:CC	acceptor_gain	1.0000

AlphaMissense

4915 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:125531948:C:A	K697N	1.000
3:125531948:C:G	K697N	1.000
3:125532007:A:G	W678R	1.000
3:125532007:A:T	W678R	1.000
3:125538570:C:A	W635C	1.000
3:125538570:C:G	W635C	1.000
3:125538572:A:G	W635R	1.000
3:125538572:A:T	W635R	1.000
3:125538577:C:T	G633E	1.000
3:125538578:C:G	G633R	1.000
3:125538578:C:T	G633R	1.000
3:125538631:A:T	V615D	1.000
3:125547442:A:G	F602S	1.000
3:125547520:A:G	L576S	1.000
3:125547523:A:G	I575T	1.000
3:125547523:A:T	I575N	1.000
3:125547527:A:G	S574P	1.000
3:125547529:C:G	R573P	1.000
3:125547532:G:T	A572D	1.000
3:125547544:G:T	P568H	1.000
3:125552208:A:G	S543P	1.000
3:125552213:C:T	G541D	1.000
3:125552214:C:G	G541R	1.000
3:125552218:G:C	F539L	1.000
3:125552218:G:T	F539L	1.000
3:125552219:A:C	F539C	1.000
3:125552219:A:G	F539S	1.000
3:125552220:A:G	F539L	1.000
3:125552485:A:C	N450K	1.000
3:125552485:A:T	N450K	1.000

dbSNP variants (sampled 300 via entrez): RS1000132680 (3:125584971 G>A,C,T), RS1000157621 (3:125544740 G>C), RS1000169369 (3:125541182 G>A,C), RS1000182866 (3:125566476 C>T), RS1000185471 (3:125585138 T>A), RS1000294875 (3:125533769 C>T), RS1000330558 (3:125530317 T>C), RS1000339534 (3:125578696 G>A), RS1000392409 (3:125567351 G>A,T), RS1000403399 (3:125576462 C>A,T), RS1000446340 (3:125564586 G>C), RS1000447201 (3:125572856 T>C), RS1000472331 (3:125583575 C>G,T), RS1000492834 (3:125543128 T>TA), RS1000521289 (3:125583762 T>C)

Disease associations

OMIM: gene MIM:606739 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	affects cotreatment, increases expression	2
Progesterone	affects cotreatment, increases expression	2
Cyclosporine	decreases expression, increases expression	2
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
decabromobiphenyl ether	decreases expression	1
tetrabromobisphenol A	decreases expression	1
perfluorooctanoic acid	decreases expression	1
aflatoxin B2	decreases methylation	1
perfluorooctane sulfonic acid	decreases expression	1
bisphenol B	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Leflunomide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Air Pollutants, Occupational	decreases expression	1
Arbutin	increases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	affects phosphorylation	1
Catechin	affects cotreatment, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Iron	increases expression	1
Ivermectin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.