OSER1-DT

Summary

OSER1-DT (OSER1 divergent transcript, HGNC:48585) is a long non-coding RNA gene on chromosome 20q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48585
Approved symbol	OSER1-DT
Name	OSER1 divergent transcript
Location	20q13.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223891
Ensembl biotype	lncRNA
Entrez	100505783
RNAcentral	URS000075B4B5 — lncRNA, 1743 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000435163, ENST00000437730, ENST00000439943, ENST00000442383, ENST00000623343, ENST00000655968, ENST00000656858, ENST00000660003, ENST00000660193, ENST00000660638, ENST00000664132, ENST00000671199, ENST00000828693, ENST00000828694, ENST00000828695

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000435163 — 4 exons

Exon	Start	End
ENSE00001670732	44211037	44211356
ENSE00001746510	44214888	44215003
ENSE00001800312	44224821	44225972
ENSE00004241488	44217367	44217682

Expression profiles

Bgee: expression breadth ubiquitous, 234 present calls, max score 96.81.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6136 / max 160.0755, expressed in 1565 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
184701	4.3618	1300
184699	1.8909	793
184700	0.3609	186

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	96.81	gold quality
cortical plate	UBERON:0005343	89.80	gold quality
ventricular zone	UBERON:0003053	89.25	gold quality
anterior cingulate cortex	UBERON:0009835	88.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	88.10	gold quality
hypothalamus	UBERON:0001898	87.79	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.67	gold quality
amygdala	UBERON:0001876	87.43	gold quality
prefrontal cortex	UBERON:0000451	87.26	gold quality
spinal cord	UBERON:0002240	87.03	gold quality
right frontal lobe	UBERON:0002810	86.92	gold quality
oviduct epithelium	UBERON:0004804	86.73	gold quality
ganglionic eminence	UBERON:0004023	86.16	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.10	gold quality
medial globus pallidus	UBERON:0002477	86.02	gold quality
substantia nigra	UBERON:0002038	85.61	gold quality
neocortex	UBERON:0001950	85.51	gold quality
nucleus accumbens	UBERON:0001882	85.25	gold quality
putamen	UBERON:0001874	85.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.10	gold quality
left ovary	UBERON:0002119	85.09	gold quality
frontal cortex	UBERON:0001870	85.02	gold quality
apex of heart	UBERON:0002098	84.93	gold quality
globus pallidus	UBERON:0001875	84.67	gold quality
midbrain	UBERON:0001891	84.65	gold quality
caudate nucleus	UBERON:0001873	84.52	gold quality
ovary	UBERON:0000992	84.24	gold quality
body of pancreas	UBERON:0001150	84.19	gold quality
cerebral cortex	UBERON:0000956	84.14	gold quality
forebrain	UBERON:0001890	84.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• OSER1-AS1 acted as a ceRNA to sponge miR-372-3p, thereby positively regulating the Rab23 expression and ultimately acting as a tumor suppressor gene in hepatocellular carcinoma progression (PMID:31635804)
• Long noncoding RNA OSER1AS1 promotes the malignant properties of nonsmall cell lung cancer by sponging microRNA4333p and thereby increasing Smad2 expression. (PMID:32627026)
• Single-nucleotide polymorphism rs4142441 and MYC co-modulated long non-coding RNA OSER1-AS1 suppresses non-small cell lung cancer by sequestering ELAVL1. (PMID:33113263)
• Expression and Clinical Significance of lncRNA OSER1-AS1 in Peripheral Blood of Patients with Non-Small Cell Lung Cancer. (PMID:34525476)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.