OSTM1-AS1

Summary

OSTM1-AS1 (OSTM1 antisense RNA 1, HGNC:43666) is a long non-coding RNA gene on chromosome 6q21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43666
Approved symbol	OSTM1-AS1
Name	OSTM1 antisense RNA 1
Location	6q21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225174
Ensembl biotype	lncRNA
Entrez	100287366
RNAcentral	URS0000ABD810 — lncRNA, 3355 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000426008, ENST00000441184, ENST00000658282

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426008 — 2 exons

Exon	Start	End
ENSE00001606531	108156202	108156698
ENSE00001685955	108123515	108123734

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 79.70.

Top tissues by expression

179 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	79.70	gold quality
ganglionic eminence	UBERON:0004023	72.29	gold quality
caudate nucleus	UBERON:0001873	60.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.63	gold quality
nucleus accumbens	UBERON:0001882	58.94	gold quality
cerebellar hemisphere	UBERON:0002245	58.74	gold quality
putamen	UBERON:0001874	57.82	gold quality
cortical plate	UBERON:0005343	57.69	silver quality
prefrontal cortex	UBERON:0000451	57.10	gold quality
right frontal lobe	UBERON:0002810	56.88	gold quality
amygdala	UBERON:0001876	56.85	gold quality
anterior cingulate cortex	UBERON:0009835	56.41	gold quality
neocortex	UBERON:0001950	54.02	gold quality
frontal cortex	UBERON:0001870	53.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	53.30	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	52.82	gold quality
forebrain	UBERON:0001890	52.32	gold quality
brain	UBERON:0000955	51.71	gold quality
cerebral cortex	UBERON:0000956	51.22	gold quality
temporal lobe	UBERON:0001871	49.64	gold quality
tendon of biceps brachii	UBERON:0008188	47.88	gold quality
Ammon’s horn	UBERON:0001954	46.89	gold quality
anatomical system	UBERON:0000467	45.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	45.48	silver quality
multicellular organism	UBERON:0000468	45.40	gold quality
material anatomical entity	UBERON:0000465	45.38	gold quality
primary visual cortex	UBERON:0002436	45.29	silver quality
cerebellum	UBERON:0002037	45.14	gold quality
body of pancreas	UBERON:0001150	43.90	silver quality
occipital lobe	UBERON:0002021	43.90	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms’ tumor by regulating the miR-514a-3p/MELK axis. (PMID:35946509)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.