OTP-AS1

Summary

OTP-AS1 (OTP antisense RNA 1, HGNC:58154) is a long non-coding RNA gene on chromosome 5q14.1.

At a glance

• Clinical variants (ClinVar): 1 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58154
Approved symbol	OTP-AS1
Name	OTP antisense RNA 1
Location	5q14.1
Locus type	RNA, long non-coding
Status	Approved
Entrez	139225791

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr5q14

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

117 predictions. Top by Δscore:

Variant	Effect	Δscore
5:77630801:C:CT	acceptor_gain	1.0000
5:77630802:G:T	acceptor_gain	1.0000
5:77630805:C:CT	acceptor_gain	1.0000
5:77630806:G:T	acceptor_gain	1.0000
5:77630790:CAGAC:C	acceptor_gain	0.9900
5:77630791:AGAC:A	acceptor_gain	0.9900
5:77630792:GAC:G	acceptor_gain	0.9900
5:77630793:AC:A	acceptor_gain	0.9900
5:77630794:CC:C	acceptor_gain	0.9900
5:77630795:C:CC	acceptor_gain	0.9900
5:77630795:CTG:C	acceptor_loss	0.9900
5:77630796:T:A	acceptor_loss	0.9900
5:77630810:C:CT	acceptor_gain	0.9900
5:77630811:G:T	acceptor_gain	0.9900
5:77630795:C:T	acceptor_gain	0.9600
5:77630793:ACC:A	acceptor_gain	0.9400
5:77630794:CCT:C	acceptor_gain	0.9400
5:77630795:CT:C	acceptor_gain	0.9400
5:77630796:T:G	acceptor_gain	0.9400
5:77630791:AGACC:A	acceptor_gain	0.9300
5:77630792:GACC:G	acceptor_gain	0.9300
5:77633772:A:AC	donor_gain	0.8900
5:77633775:A:AC	donor_gain	0.6400
5:77633776:C:CC	donor_gain	0.6400
5:77632696:T:TA	donor_gain	0.6300
5:77630817:C:CT	acceptor_gain	0.6200
5:77632635:C:A	donor_gain	0.5300
5:77633777:T:C	donor_gain	0.5000
5:77631949:C:CC	acceptor_gain	0.4900
5:77631948:A:AC	acceptor_gain	0.4800

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.