OTUD1

Summary

OTUD1 (OTU deubiquitinase 1, HGNC:27346) is a protein-coding gene on chromosome 10p12.2, encoding OTU domain-containing protein 1 (Q5VV17). Deubiquitinating enzyme that specifically hydrolyzes ‘Lys-63’-linked polyubiquitin to monoubiquitin.

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.

Source: NCBI Gene 220213 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 47 total
• Druggable target: yes
• MANE Select transcript: NM_001145373

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27346
Approved symbol	OTUD1
Name	OTU deubiquitinase 1
Location	10p12.2
Locus type	gene with protein product
Status	Approved
Aliases	DUBA7
Ensembl gene	ENSG00000165312
Ensembl biotype	protein_coding
OMIM	612022
Entrez	220213

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000376495

RefSeq mRNA: 1 — MANE Select: NM_001145373 NM_001145373

CCDS: CCDS44366

Canonical transcript exons

ENST00000376495 — 1 exons

Exon	Start	End
ENSE00001470704	23439075	23442377

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 99.04.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.0039 / max 1820.4470, expressed in 1735 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
104286	16.3323	1276
104283	4.5806	1357
104284	3.6197	1267
104281	1.5631	686
104285	1.1121	592
104282	0.4968	248
104287	0.2993	159

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	99.04	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.98	gold quality
left ventricle myocardium	UBERON:0006566	98.46	gold quality
cardiac muscle of right atrium	UBERON:0003379	97.79	silver quality
upper arm skin	UBERON:0004263	97.72	gold quality
kidney epithelium	UBERON:0004819	97.12	gold quality
tibialis anterior	UBERON:0001385	96.92	silver quality
amniotic fluid	UBERON:0000173	96.91	gold quality
oviduct epithelium	UBERON:0004804	96.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.48	gold quality
myocardium	UBERON:0002349	95.19	gold quality
upper leg skin	UBERON:0004262	94.95	gold quality
vena cava	UBERON:0004087	94.75	gold quality
body of tongue	UBERON:0011876	94.42	gold quality
bronchial epithelial cell	CL:0002328	94.10	gold quality
bronchus	UBERON:0002185	93.94	gold quality
superior surface of tongue	UBERON:0007371	93.74	gold quality
layer of synovial tissue	UBERON:0007616	93.72	gold quality
tongue	UBERON:0001723	93.69	gold quality
heart right ventricle	UBERON:0002080	93.65	gold quality
parietal pleura	UBERON:0002400	93.46	gold quality
mucosa of paranasal sinus	UBERON:0005030	92.99	gold quality
lower lobe of lung	UBERON:0008949	92.78	gold quality
quadriceps femoris	UBERON:0001377	92.68	gold quality
epithelium of mammary gland	UBERON:0003244	92.52	gold quality
mammary duct	UBERON:0001765	92.50	gold quality
synovial joint	UBERON:0002217	92.38	gold quality
vastus lateralis	UBERON:0001379	92.31	gold quality
nipple	UBERON:0002030	92.26	gold quality
bone marrow cell	CL:0002092	92.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	13.35

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

166 targeting OTUD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-340-5P	100.00	72.50	4437
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593

Literature-anchored findings (GeneRIF, showing 15)

• OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer. (PMID:24937664)
• these results suggest that OTUD1 is a novel regulator of p53 stability and activity. (PMID:28216291)
• OTU deubiquitinase 1 (OTUD1) directly deubiquitinates Smad7 Protein (SMAD7) and prevents its degradation. (PMID:29235476)
• Report that YAP is subject to non-proteolytic, K63-linked polyubiquitination by the SCF(SKP2) E3 ligase complex (SKP2), which is reversed by the deubiquitinase OTUD1. The non-proteolytic ubiquitination of YAP enhances its interaction with its nuclear binding partner TEAD, thereby inducing YAP’s nuclear localization, transcriptional activity, and growth-promoting function. (PMID:29891922)
• The data demonstrate that OTUD1 is involved in maintaining immune homeostasis and loss-of-function mutations of OTUD1 enhance the immune response and are associated with autoimmunity. (PMID:30100102)
• we report the establishment of OTUD1-specific monoclonal antibodies (mAbs), using the rat medial iliac lymph node method. The generated antibodies recognize the N-terminal portion (aa. 1-290) of human and mouse OTUD1 proteins (PMID:30130141)
• OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3. (PMID:32075857)
• The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity. (PMID:33393230)
• OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. (PMID:33898171)
• Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation. (PMID:34826170)
• OTUD1 deubiquitinase regulates NF-kappaB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways. (PMID:35941131)
• The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma. (PMID:36357400)
• The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region. (PMID:36640312)
• The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis. (PMID:37639212)
• The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-kappaB signaling. (PMID:38996928)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	otud1	ENSDARG00000100872
mus_musculus	Otud1	ENSMUSG00000043415
rattus_norvegicus	Otud1	ENSRNOG00000016950
drosophila_melanogaster	otu	FBGN0003023
drosophila_melanogaster	CG3251	FBGN0031622

Paralogs (5): OTUD5 (ENSG00000068308), OTUD6B (ENSG00000155100), OTUD4 (ENSG00000164164), OTUD3 (ENSG00000169914), OTUD6A (ENSG00000189401)

Protein

Protein identifiers

OTU domain-containing protein 1 — Q5VV17 (reviewed: Q5VV17)

Alternative names: DUBA-7

All UniProt accessions (1): Q5VV17

UniProt curated annotations — full annotation on UniProt →

Function. Deubiquitinating enzyme that specifically hydrolyzes ‘Lys-63’-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.

Domain organisation. The UIM repeat increases the specificity and efficiency of the enzyme toward ‘Lys-63’-linked polyubiquitin. Specificity is not given by the S1’ ubiquitin-binding site within the OTU domain (composed of the Cys-, His- and Variable-loops).

RefSeq proteins (1): NP_001138845* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003323	OTU_dom	Domain
IPR038765	Papain-like_cys_pep_sf	Homologous_superfamily
IPR047834	OTUD1_OTU	Domain
IPR050704	Peptidase_C85-like	Family

Pfam: PF02338

UniProt features (30 total): helix 8, strand 6, region of interest 5, compositionally biased region 3, active site 3, domain 2, chain 1, mutagenesis site 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4BOP	X-RAY DIFFRACTION	2.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VV17-F1	62.49	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 317; 320 (nucleophile); 431

Mutagenesis-validated functional residues (1):

Position	Phenotype
320	abolished deubiquitinase activity.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-5357786	TNFR1-induced proapoptotic signaling
R-HSA-5357905	Regulation of TNFR1 signaling
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway

MSigDB gene sets: 181 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL, FOSTER_TOLERANT_MACROPHAGE_UP, GOMF_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, GOBP_PROTEIN_K63_LINKED_DEUBIQUITINATION, chr10p12, GOBP_PROTEOLYSIS, GEORGES_TARGETS_OF_MIR192_AND_MIR215

GO Biological Process (3): proteolysis (GO:0006508), protein K63-linked deubiquitination (GO:0070536), protein deubiquitination (GO:0016579)

GO Molecular Function (5): cysteine-type deubiquitinase activity (GO:0004843), protein binding (GO:0005515), peptidase activity (GO:0008233), cysteine-type peptidase activity (GO:0008234), hydrolase activity (GO:0016787)

GO Cellular Component (0):

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
TNF signaling	3

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein metabolic process	1
protein deubiquitination	1
cysteine-type deubiquitinase activity	1
protein modification by small protein removal	1
cysteine-type peptidase activity	1
deubiquitinase activity	1
binding	1
hydrolase activity	1
catalytic activity, acting on a protein	1
peptidase activity	1
catalytic activity	1

Protein interactions and networks

STRING

810 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OTUD1	ZUP1	Q96AP4	927
OTUD1	YOD1	Q5VVQ6	690
OTUD1	OTUD6A	Q7L8S5	659
OTUD1	OTUB1	Q96FW1	656
OTUD1	OTUB2	Q96DC9	636
OTUD1	OTULIN	Q96BN8	626
OTUD1	OTUD7B	Q6GQQ9	602
OTUD1	OTUD4	Q01804	598
OTUD1	OTUD6B	Q8N6M0	586
OTUD1	ZRANB1	Q9UGI0	533
OTUD1	JOSD1	Q15040	504
OTUD1	USP17L2	Q6R6M4	496
OTUD1	OTUD7A	Q8TE49	476
OTUD1	USP49	Q70CQ1	476
OTUD1	JOSD2	Q8TAC2	476

IntAct

10 interactions, top by confidence:

A	B	Type	Score
RIPK2	OTUD1	psi-mi:“MI:0915”(physical association)	0.460
RIPK2	OTUD1	psi-mi:“MI:0403”(colocalization)	0.460
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
OTUD1	LOC392787	psi-mi:“MI:0914”(association)	0.350
USP11	PRRC2B	psi-mi:“MI:0914”(association)	0.350
OTUD1	ppdK	psi-mi:“MI:0915”(physical association)	0.000
OTUD1	rpiA2	psi-mi:“MI:0915”(physical association)	0.000
OTUD1	ahpC	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (235): OTUD1 (Affinity Capture-MS), TP53 (Affinity Capture-Western), OTUD1 (Affinity Capture-Western), OTUD1 (Reconstituted Complex), SMAD7 (Reconstituted Complex), OTUD1 (Reconstituted Complex), OTUD1 (Affinity Capture-Western), SMAD7 (Biochemical Activity), YAP1 (Affinity Capture-Western), OTUD1 (Affinity Capture-Western), YAP1 (Reconstituted Complex), YAP1 (Biochemical Activity), OTUD1 (Affinity Capture-Western), SMURF1 (Affinity Capture-Western), SMURF1 (Co-localization)

ESM2 similar proteins: A6NKL6, A6NNE9, A6P320, D3YYI7, E9Q0B3, F5H4A9, O60346, P0C1G7, P0C7U0, P0DPB3, P39881, P53349, Q0P496, Q13233, Q147X3, Q2TBI2, Q3TZ87, Q49LS4, Q52L14, Q5GH59, Q5GH67, Q5GH76, Q5VV17, Q62925, Q66JB6, Q6NS60, Q80TE3, Q86VE0, Q86YJ5, Q8BGW2, Q8CBH7, Q8R554, Q8TC41, Q8TE49, Q8TF61, Q96EP1, Q96SQ7, Q99MX7, Q99NA2, Q9BXQ6

Diamond homologs: B2RRE7, Q01804, Q08BW0, Q2YDU3, Q3U2S4, Q5VV17, Q640H3, Q6GL44, Q7ZX21, Q96G74, Q9CUB6, Q9LZF7, Q9VR20, Q9XIP2, F4K3M6, Q9NP73, Q9SGA5, P10383, Q9D8C3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	4
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

45 predictions. Top by Δscore:

Variant	Effect	Δscore
10:23439691:CTTCG:C	acceptor_gain	0.6400
10:23439695:G:T	acceptor_gain	0.6200
10:23439700:G:GA	donor_gain	0.5000
10:23439604:GACCG:G	donor_gain	0.4200
10:23439699:T:TA	donor_gain	0.4100
10:23440406:GAC:G	acceptor_gain	0.4100
10:23439694:CG:C	acceptor_gain	0.4000
10:23439692:TTCG:T	acceptor_gain	0.3700
10:23440405:A:AG	acceptor_gain	0.3700
10:23440406:G:GG	acceptor_gain	0.3700
10:23440405:AGAC:A	acceptor_gain	0.3400
10:23440406:GACG:G	acceptor_gain	0.3400
10:23439609:G:GG	donor_gain	0.3200
10:23439693:TCG:T	acceptor_gain	0.3000
10:23439605:ACCGG:A	donor_loss	0.2800
10:23439606:CCG:C	donor_loss	0.2800
10:23439607:CG:C	donor_loss	0.2800
10:23439608:GG:G	donor_loss	0.2800
10:23439609:GTG:G	donor_loss	0.2800
10:23439610:T:TA	donor_loss	0.2800
10:23439611:G:GC	donor_loss	0.2800
10:23439612:A:AT	donor_loss	0.2800
10:23439613:G:T	donor_loss	0.2800
10:23439607:C:CA	donor_gain	0.2700
10:23440341:CCG:C	acceptor_gain	0.2500
10:23440249:C:A	acceptor_gain	0.2400
10:23439644:G:T	donor_gain	0.2300
10:23440398:T:G	acceptor_loss	0.2300
10:23440401:TTCCA:T	acceptor_loss	0.2300
10:23440402:TCCAG:T	acceptor_loss	0.2300

AlphaMissense

3097 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:23440406:G:C	D317H	1.000
10:23440407:A:T	D317V	1.000
10:23440410:G:A	G318D	1.000
10:23440410:G:T	G318V	1.000
10:23440415:T:C	C320R	1.000
10:23440416:G:A	C320Y	1.000
10:23440417:C:G	C320W	1.000
10:23440425:G:C	R323P	1.000
10:23440427:G:C	A324P	1.000
10:23440428:C:A	A324D	1.000
10:23440431:T:A	V325D	1.000
10:23440476:G:C	R340T	1.000
10:23440476:G:T	R340M	1.000
10:23440477:G:C	R340S	1.000
10:23440477:G:T	R340S	1.000
10:23440518:T:C	F354S	1.000
10:23440550:T:C	F365L	1.000
10:23440552:T:A	F365L	1.000
10:23440552:T:G	F365L	1.000
10:23440580:T:A	W375R	1.000
10:23440580:T:C	W375R	1.000
10:23440638:T:C	L394S	1.000
10:23440728:T:C	L424P	1.000
10:23440730:A:C	S425R	1.000
10:23440732:T:A	S425R	1.000
10:23440732:T:G	S425R	1.000
10:23440733:T:A	W426R	1.000
10:23440733:T:C	W426R	1.000
10:23440737:T:C	L427P	1.000
10:23440746:G:A	G430E	1.000

dbSNP variants (sampled 300 via entrez): RS1000356051 (10:23442014 C>T), RS1000744107 (10:23441211 C>A), RS1001691884 (10:23438424 C>T), RS1002021735 (10:23442762 T>A), RS1002028788 (10:23437127 G>C), RS1002642445 (10:23439058 G>A,T), RS1002684380 (10:23439349 G>C), RS1003020674 (10:23440269 C>A,G,T), RS1003617692 (10:23441803 C>T), RS1003870886 (10:23441839 G>A,C), RS1004096318 (10:23441453 C>T), RS1004287409 (10:23438443 T>C), RS1004430744 (10:23437499 T>A,C), RS1004487178 (10:23441546 T>G), RS1004890406 (10:23440773 C>G,T)

Disease associations

OMIM: gene MIM:612022 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001957_8	Obesity (early onset extreme)	1.000000e-07
GCST007277_14	Tourette syndrome	6.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4630832 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

57 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Acetaminophen	increases expression	2
Air Pollutants	decreases expression, affects expression, increases abundance	2
Benzo(a)pyrene	increases expression, decreases methylation	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	decreases expression, increases expression	2
Cyclosporine	increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
hydroxyhydroquinone	increases expression	1
methylparaben	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
ferrous chloride	increases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
nickel sulfate	increases expression	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, increases expression	1
avobenzone	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
nutlin 3	affects cotreatment, increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
NSC 689534	affects binding, increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Ethanol	decreases expression	1
Catechin	affects cotreatment, increases expression	1
Copper	affects binding, increases expression	1

ChEMBL screening assays

3 unique, capped per target: 3 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4605996	Binding	Inhibition of human 6His-tagged OTUD1 CD (270 to 481 residues) expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine110-glycine using Ubiquitin-Rhodamine110-glycine as substrate by f	Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. — J Med Chem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TB70	HAP1 OTUD1 (-) 1	Cancer cell line	Male
CVCL_TB71	HAP1 OTUD1 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.