OTUD6B-AS1

Summary

OTUD6B-AS1 (OTUD6B antisense RNA 1, HGNC:50466) is a long non-coding RNA gene on chromosome 8q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50466
Approved symbol	OTUD6B-AS1
Name	OTUD6B antisense RNA 1
Location	8q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	GS1-251I9.4
Ensembl gene	ENSG00000253738
Ensembl biotype	lncRNA
Entrez	100506365
RNAcentral	URS000075D817 — lncRNA, 4361 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000522817, ENST00000524003, ENST00000657110, ENST00000659792, ENST00000723094, ENST00000723095, ENST00000723096

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000522817 — 3 exons

Exon	Start	End
ENSE00002092420	91059318	91063746
ENSE00002101726	91069931	91070192
ENSE00002139750	91069579	91069822

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 97.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.6810 / max 2023.8596, expressed in 1793 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93917	19.1787	1757
93919	7.2535	1659
93918	2.8706	1289
93921	1.4466	842
93920	0.7662	415
93915	0.7655	366
93911	0.4447	166
93916	0.3539	122
93913	0.2950	100
93912	0.1938	61

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	97.66	gold quality
calcaneal tendon	UBERON:0003701	95.70	gold quality
left ventricle myocardium	UBERON:0006566	95.12	gold quality
heart right ventricle	UBERON:0002080	93.56	gold quality
cardiac muscle of right atrium	UBERON:0003379	92.98	gold quality
islet of Langerhans	UBERON:0000006	92.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.15	gold quality
prefrontal cortex	UBERON:0000451	91.75	gold quality
epithelial cell of pancreas	CL:0000083	91.72	gold quality
myocardium	UBERON:0002349	91.65	gold quality
anterior cingulate cortex	UBERON:0009835	91.61	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.25	gold quality
adult organism	UBERON:0007023	91.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.15	gold quality
tendon	UBERON:0000043	91.09	gold quality
cerebellar cortex	UBERON:0002129	91.03	gold quality
hypothalamus	UBERON:0001898	91.00	gold quality
cerebellar hemisphere	UBERON:0002245	91.00	gold quality
cortical plate	UBERON:0005343	90.95	gold quality
nucleus accumbens	UBERON:0001882	90.59	gold quality
right frontal lobe	UBERON:0002810	90.54	gold quality
mucosa of paranasal sinus	UBERON:0005030	90.41	gold quality
cerebellum	UBERON:0002037	90.34	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.26	gold quality
amygdala	UBERON:0001876	90.24	gold quality
caudate nucleus	UBERON:0001873	90.22	gold quality
spinal cord	UBERON:0002240	90.16	gold quality
putamen	UBERON:0001874	90.06	gold quality
cardiac atrium	UBERON:0002081	90.03	gold quality
neocortex	UBERON:0001950	90.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• OTUD6B-AS1 Inhibits Viability, Migration, and Invasion of Thyroid Carcinoma by Targeting miR-183-5p and miR-21. (PMID:32256450)
• LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability. (PMID:34740994)
• LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer. (PMID:37184781)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.