OTX2-AS1

Summary

OTX2-AS1 (OTX2 antisense RNA 1, HGNC:43906) is a long non-coding RNA gene on chromosome 14q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43906
Approved symbol	OTX2-AS1
Name	OTX2 antisense RNA 1
Location	14q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	OTX2OS1
Ensembl gene	ENSG00000248550
Ensembl biotype	lncRNA
Entrez	100309464
RNAcentral	URS0000BC44B3 — lncRNA, 2928 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000534909, ENST00000554358, ENST00000554428, ENST00000554725, ENST00000653425, ENST00000842825, ENST00000842826, ENST00000842827, ENST00000842828, ENST00000842829, ENST00000842830

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000534909 — 4 exons

Exon	Start	End
ENSE00002211616	56897540	56897648
ENSE00002266509	56813183	56813469
ENSE00002290713	56898268	56898345
ENSE00002296966	56928880	56930833

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 96.17.

FANTOM5 (CAGE): breadth broad, TPM avg 1.9634 / max 596.9502, expressed in 200 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
139789	0.9966	175
139785	0.5158	69
139787	0.3471	50
139786	0.0677	21
139788	0.0362	22

Top tissues by expression

203 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	96.17	gold quality
pigmented layer of retina	UBERON:0001782	96.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.75	silver quality
cortical plate	UBERON:0005343	72.13	gold quality
sural nerve	UBERON:0015488	67.11	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.79	gold quality
ventricular zone	UBERON:0003053	63.60	gold quality
monocyte	CL:0000576	56.59	gold quality
ganglionic eminence	UBERON:0004023	55.86	silver quality
substantia nigra	UBERON:0002038	54.40	gold quality
lower lobe of lung	UBERON:0008949	53.78	silver quality
midbrain	UBERON:0001891	53.36	gold quality
islet of Langerhans	UBERON:0000006	52.65	gold quality
stromal cell of endometrium	CL:0002255	52.47	silver quality
muscle of leg	UBERON:0001383	52.13	gold quality
gastrocnemius	UBERON:0001388	51.82	gold quality
hypothalamus	UBERON:0001898	50.42	gold quality
corpus callosum	UBERON:0002336	49.89	gold quality
adenohypophysis	UBERON:0002196	49.63	gold quality
lateral nuclear group of thalamus	UBERON:0002736	49.44	silver quality
prefrontal cortex	UBERON:0000451	48.75	gold quality
right lobe of liver	UBERON:0001114	48.00	silver quality
adrenal tissue	UBERON:0018303	46.35	silver quality
body of pancreas	UBERON:0001150	46.33	silver quality
pancreas	UBERON:0001264	46.26	gold quality
right ovary	UBERON:0002118	45.94	gold quality
right adrenal gland	UBERON:0001233	45.93	gold quality
pituitary gland	UBERON:0000007	45.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	45.74	silver quality
germinal epithelium of ovary	UBERON:0001304	45.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups. (PMID:32752121)
• Upregulation of OTX2-AS1 is Associated With Immune Infiltration and Predicts Prognosis of Gastric Cancer. (PMID:36740995)
• The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma. (PMID:37976029)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.