OVAAL

Summary

OVAAL (ovarian adenocarcinoma amplified long non-coding RNA, HGNC:49422) is a long non-coding RNA gene on chromosome 1q25.3.

Predicted to enable pre-mRNA branch point binding activity. Predicted to be involved in mRNA branch site recognition. Predicted to be part of U2 snRNP.

Source: NCBI Gene 148756 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49422
Approved symbol	OVAAL
Name	ovarian adenocarcinoma amplified long non-coding RNA
Location	1q25.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC01131, OVAL, RMEL2
Ensembl gene	ENSG00000236719
Ensembl biotype	lncRNA
Entrez	148756
RNAcentral	URS00026A1AED — lncRNA, 1501 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000442621, ENST00000648175, ENST00000660699, ENST00000662859, ENST00000668742, ENST00000673955, ENST00000718013, ENST00000718014, ENST00000718015, ENST00000744191, ENST00000818816, ENST00000818817, ENST00000818818

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442621 — 3 exons

Exon	Start	End
ENSE00001599647	180565251	180566518
ENSE00001700122	180558964	180559055
ENSE00002076858	180562204	180562344

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 74.67.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0545 / max 11.4203, expressed in 24 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
6960	0.0488	21
201828	0.0057	2

Top tissues by expression

164 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.67	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.07	gold quality
heart left ventricle	UBERON:0002084	69.01	gold quality
cardiac ventricle	UBERON:0002082	68.03	gold quality
apex of heart	UBERON:0002098	67.72	gold quality
heart	UBERON:0000948	64.07	gold quality
right atrium auricular region	UBERON:0006631	60.55	gold quality
cardiac atrium	UBERON:0002081	60.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	53.43	silver quality
myocardium	UBERON:0002349	46.99	silver quality
mammalian vulva	UBERON:0000997	46.40	gold quality
lymph node	UBERON:0000029	46.05	silver quality
Brodmann (1909) area 9	UBERON:0013540	45.76	silver quality
upper leg skin	UBERON:0004262	45.74	silver quality
islet of Langerhans	UBERON:0000006	45.46	silver quality
body of uterus	UBERON:0009853	45.18	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	44.96	silver quality
muscle of leg	UBERON:0001383	44.92	silver quality
gastrocnemius	UBERON:0001388	44.32	silver quality
ascending aorta	UBERON:0001496	43.58	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
thoracic aorta	UBERON:0001515	43.22	gold quality
anatomical system	UBERON:0000467	42.96	gold quality
multicellular organism	UBERON:0000468	42.78	gold quality
material anatomical entity	UBERON:0000465	42.76	gold quality
pylorus	UBERON:0001166	42.66	gold quality
spleen	UBERON:0002106	42.59	silver quality
secondary oocyte	CL:0000655	42.57	gold quality
adult mammalian kidney	UBERON:0000082	42.53	silver quality
aorta	UBERON:0000947	42.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Identified an up-regulated lncRNA, ovarian adenocarcinoma-amplified lncRNA (OVAAL), that conferred apoptotic resistance in multiple cancer types. Analysis of clinical samples revealed OVAAL expression was significantly increased in colorectal cancers and melanoma in comparison to the corresponding normal tissues. Functional investigations showed that OVAAL depletion significantly inhibited cancer cell proliferation. (PMID:30478051)
• Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5-fluorouracil resistance in gastric cancer. (PMID:35657686)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.