P2RY10

Summary

P2RY10 (P2Y receptor family member 10, HGNC:19906) is a protein-coding gene on chromosome Xq21.1, encoding Putative P2Y purinoceptor 10 (O00398). Putative receptor for purines coupled to G-proteins.

The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed.

Source: NCBI Gene 27334 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 57 total
• Druggable target: yes
• MANE Select transcript: NM_014499

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19906
Approved symbol	P2RY10
Name	P2Y receptor family member 10
Location	Xq21.1
Locus type	gene with protein product
Status	Approved
Aliases	P2Y10, LPS2
Ensembl gene	ENSG00000078589
Ensembl biotype	protein_coding
OMIM	300529
Entrez	27334

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000171757, ENST00000461541, ENST00000475374, ENST00000544091, ENST00000899704

RefSeq mRNA: 5 — MANE Select: NM_014499 NM_001324218, NM_001324221, NM_001324225, NM_014499, NM_198333

CCDS: CCDS14442

Canonical transcript exons

ENST00000171757 — 4 exons

Exon	Start	End
ENSE00001337058	78952193	78952335
ENSE00001337060	78947815	78947863
ENSE00001897011	78960508	78963727
ENSE00003841208	78945391	78945495

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 89.53.

FANTOM5 (CAGE): breadth broad, TPM avg 10.4053 / max 541.9643, expressed in 254 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196790	9.0560	243
196791	1.3493	142

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	89.53	gold quality
epithelium of nasopharynx	UBERON:0001951	85.12	gold quality
blood	UBERON:0000178	84.42	gold quality
granulocyte	CL:0000094	83.70	gold quality
vermiform appendix	UBERON:0001154	83.48	gold quality
spleen	UBERON:0002106	81.57	gold quality
colonic epithelium	UBERON:0000397	81.09	gold quality
bone marrow	UBERON:0002371	80.88	gold quality
superficial temporal artery	UBERON:0001614	80.54	gold quality
caecum	UBERON:0001153	79.52	gold quality
bone marrow cell	CL:0002092	78.11	gold quality
tonsil	UBERON:0002372	77.91	gold quality
gall bladder	UBERON:0002110	75.24	gold quality
rectum	UBERON:0001052	74.84	gold quality
leukocyte	CL:0000738	72.79	gold quality
jejunal mucosa	UBERON:0000399	71.24	gold quality
monocyte	CL:0000576	71.08	gold quality
mononuclear cell	CL:0000842	71.06	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.25	gold quality
small intestine	UBERON:0002108	68.52	gold quality
trabecular bone tissue	UBERON:0002483	66.45	silver quality
palpebral conjunctiva	UBERON:0001812	65.18	gold quality
duodenum	UBERON:0002114	65.01	gold quality
smooth muscle tissue	UBERON:0001135	64.77	gold quality
mucosa of transverse colon	UBERON:0004991	63.75	gold quality
mucosa of sigmoid colon	UBERON:0004993	63.24	silver quality
thymus	UBERON:0002370	62.68	silver quality
colonic mucosa	UBERON:0000317	61.61	gold quality
upper lobe of left lung	UBERON:0008952	61.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.62

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): SPI1

miRNA regulators (miRDB)

98 targeting P2RY10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-576-5P	99.84	70.46	2582

Literature-anchored findings (GeneRIF, showing 4)

• The P2Y(10) receptor is the first receptor identified as a dual lysophospholipid receptor. (PMID:18466763)
• Our data show that the LysoPS-induced eosinophil degranulation most likely occurs through P2Y10. These findings suggest that LysoPS plays a specific role in eosinophils and introduces the possibility of LysoPS/P2Y10-based therapeutics in the treatment of eosinophilic diseases. (PMID:29700886)
• G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. (PMID:34815397)
• The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13. (PMID:38357893)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	p2ry10	ENSDARG00000062811
mus_musculus	P2ry10	ENSMUSG00000050921
rattus_norvegicus	P2ry10	ENSRNOG00000037839

Paralogs (16): GPR18 (ENSG00000125245), F2RL3 (ENSG00000127533), GPR55 (ENSG00000135898), LPAR6 (ENSG00000139679), GPR65 (ENSG00000140030), GPR17 (ENSG00000144230), LPAR4 (ENSG00000147145), CYSLTR2 (ENSG00000152207), F2RL2 (ENSG00000164220), F2RL1 (ENSG00000164251), CYSLTR1 (ENSG00000173198), GPR4 (ENSG00000177464), GPR35 (ENSG00000178623), F2R (ENSG00000181104), P2RY8 (ENSG00000182162), GPR20 (ENSG00000204882)

Protein

Protein identifiers

Putative P2Y purinoceptor 10 — O00398 (reviewed: O00398)

Alternative names: P2Y-like receptor

All UniProt accessions (1): O00398

UniProt curated annotations — full annotation on UniProt →

Function. Putative receptor for purines coupled to G-proteins.

Subcellular location. Cell membrane.

Tissue specificity. Weakly expressed in blood leukocytes.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (5): NP_001311147, NP_001311150, NP_001311154, NP_055314, NP_938147 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF00001

UniProt features (36 total): helix 13, topological domain 8, transmembrane region 7, glycosylation site 3, strand 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8KGG	ELECTRON MICROSCOPY	3.06

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O00398-F1	84.06	0.52

Antibody-complex structures (SAbDab): 1 — 8KGG

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 106–181

Glycosylation sites (3): 16, 26, 178

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-416476	G alpha (q) signalling events
R-HSA-417957	P2Y receptors

MSigDB gene sets: 255 (showing top): BROWNE_HCMV_INFECTION_30MIN_DN, GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_CD8A_DC_UP, GSE45365_NK_CELL_VS_BCELL_UP, BROWNE_HCMV_INFECTION_6HR_DN, MORF_FLT1, MORF_MSH3, BASSO_B_LYMPHOCYTE_NETWORK, MODULE_45, MODULE_64, MORF_BRCA1, REACTOME_P2Y_RECEPTORS, MORF_ESR1, MORF_RAD51L3, NFKB_Q6

GO Biological Process (2): G protein-coupled receptor signaling pathway (GO:0007186), signal transduction (GO:0007165)

GO Molecular Function (1): G protein-coupled receptor activity (GO:0004930)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
GPCR downstream signalling	1
Nucleotide-like (purinergic) receptors	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	1
signal transduction	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

956 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
P2RY10	LPAR2	Q9HBW0	592
P2RY10	LPAR1	P78351	582
P2RY10	LPAR3	Q9UBY5	581
P2RY10	ADORA3	P0DMS8	539
P2RY10	ENPP2	Q13822	475
P2RY10	PLA1A	Q53H76	455
P2RY10	GPR87	Q9BY21	438
P2RY10	GDPD1	Q8N9F7	430
P2RY10	P2RX5	Q93086	425
P2RY10	P2RY2	P41231	413
P2RY10	GDPD3	Q7L5L3	387
P2RY10	HRH1	P35367	379
P2RY10	P2RX1	P51575	377
P2RY10	ABHD16A	O95870	375
P2RY10	P2RX6	O15547	368

IntAct

4 interactions, top by confidence:

A	B	Type	Score
P2RY10	ATM	psi-mi:“MI:0914”(association)	0.530
P2RY10	POTEF	psi-mi:“MI:0914”(association)	0.350
P2RY10	TTI1	psi-mi:“MI:0914”(association)	0.350

BioGRID (105): IPO13 (Affinity Capture-MS), CAV1 (Affinity Capture-MS), TNPO3 (Affinity Capture-MS), SPPL3 (Affinity Capture-MS), ATP6V1H (Affinity Capture-MS), TUBGCP2 (Affinity Capture-MS), XPO1 (Affinity Capture-MS), KIAA1524 (Affinity Capture-MS), EXOC6 (Affinity Capture-MS), TUBB8 (Affinity Capture-MS), FASTKD3 (Affinity Capture-MS), DYM (Affinity Capture-MS), CLTCL1 (Affinity Capture-MS), EARS2 (Affinity Capture-MS), LTN1 (Affinity Capture-MS)

ESM2 similar proteins: A0A4W3GG95, A7YY44, B0F9W3, B0UXR0, B2GV46, B3G515, B5X337, E7FEL0, O00398, O46685, O70526, P21556, P25023, P25105, P25116, P26824, P30411, P30558, P32299, P43657, P46002, P46093, P49019, P50132, P56488, Q00991, Q15743, Q1JQB3, Q28642, Q3UFD7, Q4G072, Q4KLH9, Q61038, Q62035, Q80Z39, Q8BFQ3, Q8BFU7, Q8BLG2, Q8BMC0, Q8BUD0

Diamond homologs: A0T2N3, A5PLE7, B0UXR0, B5X337, D4A7K7, E9QJ73, O00254, O00398, O08675, O09047, O35210, O35811, O77590, P25095, P25104, P29089, P29754, P29755, P30555, P30556, P30937, P31391, P32249, P32250, P34976, P35366, P35383, P41231, P41232, P43240, P43657, P47748, P47774, P49660, P51582, P55085, P55086, P58826, P79928, P79960

SIGNOR signaling

8 interactions.

A	Effect	B	Mechanism
P2RY10	“up-regulates activity”	GNAI1	binding
P2RY10	“up-regulates activity”	GNAI3	binding
P2RY10	“up-regulates activity”	GNAO1	binding
P2RY10	“up-regulates activity”	GNAZ	binding
P2RY10	“up-regulates activity”	GNA14	binding
P2RY10	“up-regulates activity”	GNA12	binding
P2RY10	“up-regulates activity”	GNA13	binding
“lysophosphatidylserine 14:0(1-)”	“up-regulates activity”	P2RY10	“chemical activation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

689 predictions. Top by Δscore:

Variant	Effect	Δscore
X:78945484:C:G	donor_gain	0.9900
X:78945493:AGGGT:A	donor_loss	0.9900
X:78945494:GG:G	donor_gain	0.9900
X:78945495:GG:G	donor_gain	0.9900
X:78945495:GGT:G	donor_loss	0.9900
X:78945496:G:GA	donor_loss	0.9900
X:78945496:G:GG	donor_gain	0.9900
X:78945497:TAAG:T	donor_loss	0.9900
X:78960497:ACTTT:A	acceptor_gain	0.9800
X:78960501:T:TA	acceptor_gain	0.9800
X:78960502:G:A	acceptor_gain	0.9800
X:78960497:A:AG	acceptor_gain	0.9700
X:78956367:ACT:A	donor_gain	0.9600
X:78945493:AGG:A	donor_gain	0.9500
X:78945494:GGG:G	donor_gain	0.9500
X:78945491:CCAGG:C	donor_gain	0.9400
X:78945492:CAGG:C	donor_gain	0.9400
X:78960506:A:AG	acceptor_gain	0.9400
X:78960507:G:GG	acceptor_gain	0.9400
X:78960502:GGGCA:G	acceptor_loss	0.9300
X:78960503:GGCA:G	acceptor_loss	0.9300
X:78960504:GCA:G	acceptor_loss	0.9300
X:78960505:CA:C	acceptor_loss	0.9300
X:78960507:G:GC	acceptor_loss	0.9300
X:78960498:C:G	acceptor_gain	0.9200
X:78960491:T:A	acceptor_loss	0.9100
X:78960507:GGA:G	acceptor_gain	0.9100
X:78945429:GA:G	donor_gain	0.9000
X:78952337:TACC:T	donor_gain	0.8700
X:78952338:ACCA:A	donor_gain	0.8700

AlphaMissense

2265 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:78960902:A:C	S128R	0.998
X:78960904:T:A	S128R	0.998
X:78960904:T:G	S128R	0.998
X:78960745:C:A	N75K	0.997
X:78960745:C:G	N75K	0.997
X:78960977:A:C	S153R	0.997
X:78960979:T:A	S153R	0.997
X:78960979:T:G	S153R	0.997
X:78960989:T:A	W157R	0.997
X:78960989:T:C	W157R	0.997
X:78961286:T:C	F256L	0.997
X:78961288:C:A	F256L	0.997
X:78961288:C:G	F256L	0.997
X:78960817:G:C	W99C	0.996
X:78960817:G:T	W99C	0.996
X:78961139:T:C	F207L	0.996
X:78961141:T:A	F207L	0.996
X:78961141:T:G	F207L	0.996
X:78961403:A:C	S295R	0.996
X:78961405:T:A	S295R	0.996
X:78961405:T:G	S295R	0.996
X:78960747:T:C	L76P	0.995
X:78961001:G:A	G161R	0.994
X:78961001:G:C	G161R	0.994
X:78960783:C:G	P88R	0.993
X:78960878:A:C	S120R	0.993
X:78960880:C:A	S120R	0.993
X:78960880:C:G	S120R	0.993
X:78961149:C:G	P210R	0.993
X:78960815:T:A	W99R	0.992

dbSNP variants (sampled 300 via entrez): RS1000223354 (X:78945624 A>T), RS1000407377 (X:78952740 C>T), RS1000532546 (X:78951582 G>GA), RS1000603457 (X:78944790 A>T), RS1000647232 (X:78951278 G>C), RS1000654740 (X:78960372 C>T), RS1000698254 (X:78945955 G>T), RS1000762128 (X:78961945 A>G), RS1001194534 (X:78961430 C>T), RS1001245718 (X:78955340 T>A), RS1001652766 (X:78956353 G>A,T), RS1002697430 (X:78955064 T>A), RS1002720935 (X:78947230 A>C,G), RS1002732500 (X:78958502 C>A), RS1002752083 (X:78947579 T>C)

Disease associations

OMIM: gene MIM:300529 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002318_175	Rheumatoid arthritis	4.000000e-08
GCST002318_84	Rheumatoid arthritis	4.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL3562166 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with emerging pharmacology

Most potent curated ligand interactions (2 total), top 2:

Ligand	Action	Affinity	Parameter
sphingosine 1-phosphate	Agonist	7.3	pEC50
LPA	Agonist	6.9	pEC50

ChEMBL bioactivities

139 potent at pChembl≥5 of 139 total, top 50 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.89	EC50	1.3	nM	CHEMBL3577182
8.87	EC50	1.349	nM	CHEMBL3577182
8.77	EC50	1.7	nM	CHEMBL3577179
8.77	EC50	1.698	nM	CHEMBL3577179
8.71	EC50	1.95	nM	CHEMBL3577262
8.70	EC50	2	nM	CHEMBL3577171
8.70	EC50	1.995	nM	CHEMBL3577171
8.70	EC50	2	nM	CHEMBL3577262
8.58	EC50	2.63	nM	CHEMBL3577174
8.57	EC50	2.7	nM	CHEMBL3577174
8.50	EC50	3.162	nM	CHEMBL3577170
8.49	EC50	3.2	nM	CHEMBL3577170
8.48	EC50	3.3	nM	CHEMBL3577262
8.48	EC50	3.311	nM	CHEMBL3577262
8.43	EC50	3.7	nM	CHEMBL3577178
8.43	EC50	3.715	nM	CHEMBL3577178
8.22	EC50	6.026	nM	CHEMBL5396462
8.21	EC50	6.1	nM	CHEMBL5396462
8.10	EC50	8	nM	CHEMBL5434445
8.10	EC50	7.943	nM	CHEMBL5434445
8.00	EC50	10	nM	CHEMBL1742484
7.98	EC50	10.47	nM	CHEMBL1742484
7.92	EC50	12	nM	CHEMBL3577172
7.91	EC50	12.3	nM	CHEMBL3577172
7.90	EC50	12.59	nM	CHEMBL1742484
7.89	EC50	13	nM	CHEMBL3577175
7.89	EC50	12.88	nM	CHEMBL3577175
7.89	EC50	13	nM	CHEMBL1742484
7.84	EC50	14.45	nM	CHEMBL1742484
7.82	EC50	15	nM	CHEMBL1742484
7.68	EC50	21	nM	CHEMBL3577150
7.67	EC50	21.38	nM	CHEMBL3577150
7.66	EC50	22	nM	CHEMBL5421007
7.66	EC50	21.88	nM	CHEMBL5421007
7.66	EC50	22	nM	CHEMBL1742484
7.65	EC50	22.39	nM	CHEMBL1742484
7.60	EC50	25	nM	CHEMBL3577137
7.60	EC50	25.12	nM	CHEMBL3577137
7.59	EC50	25.7	nM	CHEMBL3577145
7.58	EC50	26	nM	CHEMBL3577145
7.58	EC50	26	nM	CHEMBL5417405
7.58	EC50	26.3	nM	CHEMBL5417405
7.55	EC50	28	nM	CHEMBL1742484
7.55	EC50	28.18	nM	CHEMBL1742484
7.49	EC50	32.36	nM	CHEMBL3577180
7.49	EC50	32.36	nM	CHEMBL5417405
7.48	EC50	33	nM	CHEMBL3577180
7.48	EC50	33	nM	CHEMBL5417405
7.41	EC50	39	nM	CHEMBL3577138
7.41	EC50	38.9	nM	CHEMBL3577138

PubChem BioAssay actives

140 with measured affinity, of 177 total; 50 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
(2S)-2-amino-3-[[(2R)-2-fluoro-3-[3-(2-undecoxyphenyl)propanoyloxy]propoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0013	uM
(2S)-2-amino-3-[hydroxy-[3-[3-(2-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0017	uM
(2S)-2-amino-3-[[2,2-difluoro-3-[3-(2-undecoxyphenyl)propanoyloxy]propoxy]-hydroxyphosphoryl]oxypropanoic acid	2008507: Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.0019	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(2-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0020	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(2-pentadecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0026	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(2-nonoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0032	uM
(2S)-2-amino-3-[hydroxy-[3-[3-(2-nonoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0037	uM
(2S)-2-amino-3-[3-[3-[2-[4-(3,5-diphenylphenyl)phenoxy]phenyl]propanoyloxy]propoxy-hydroxyphosphoryl]oxypropanoic acid	2008507: Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.0060	uM
(2S)-2-amino-3-[hydroxy-[3-[3-[2-[4-(4-phenylphenyl)phenoxy]phenyl]propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	2008507: Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.0079	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid	2008509: Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.0100	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(3-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0120	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(3-pentadecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0129	uM
(2S)-2-amino-3-[3-hexadecanoyloxypropoxy(hydroxy)phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0210	uM
(2S)-2-amino-3-[hydroxy-[3-[3-[2-[4-(3-phenylphenyl)phenoxy]phenyl]propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	2008507: Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.0219	uM
(2S)-2-amino-3-[hydroxy-[3-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0250	uM
(2S)-2-amino-3-[[(2R)-3-hexadecanoyloxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0257	uM
(2S)-2-amino-3-[hydroxy-[3-[3-[2-(4-phenylphenoxy)phenyl]propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	2008511: Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.0260	uM
(2S)-2-amino-3-[hydroxy-[3-[3-(3-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0324	uM
(2S)-2-amino-3-[hydroxy-[(2S)-2-hydroxy-3-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0389	uM
(2S)-2-amino-3-[hydroxy(3-tetradecanoyloxypropoxy)phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0447	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(4-pentadecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0530	uM
(2S)-2-amino-3-[hydroxy-[3-[3-(4-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0549	uM
(2S)-2-amino-3-[3-[(Z)-hexadec-9-enoyl]oxypropoxy-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0575	uM
(2S)-2-amino-3-[[2,2-dimethyl-3-[(Z)-octadec-9-enoyl]oxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0580	uM
(2S)-2-amino-3-[hydroxy-[3-[3-[2-(3-phenylphenoxy)phenyl]propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	2008507: Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.0617	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-tetradecanoyloxypropoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0720	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(4-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0830	uM
(2S)-2-amino-3-[3-[3-(2-heptoxyphenyl)propanoyloxy]propoxy-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0851	uM
(2S)-2-amino-3-[[(2R)-3-[(Z)-hexadec-9-enoyl]oxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0851	uM
(2S)-2-amino-3-[hydroxy(3-octadecanoyloxypropoxy)phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.0870	uM
(2S)-2-amino-3-[[(2R)-3-[3-(3-heptoxyphenyl)propanoyloxy]-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.1000	uM
(2S)-2-amino-3-[hydroxy-[3-[3-[2-[4-(2-phenylphenyl)phenoxy]phenyl]propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	2008507: Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.1000	uM
(2S)-2-amino-3-[3-[3-[2-(3,5-diphenylphenoxy)phenyl]propanoyloxy]propoxy-hydroxyphosphoryl]oxypropanoic acid	2008507: Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.1175	uM
(2S)-2-amino-3-[[(2R)-3-[3-(2-heptoxyphenyl)propanoyloxy]-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.1200	uM
[(2R)-3-[[(2S)-2-amino-3-methoxy-3-oxopropoxy]-hydroxyphosphoryl]oxy-2-hydroxypropyl] (Z)-octadec-9-enoate	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.1400	uM
(2S)-2-amino-3-[[(2R)-2-fluoro-3-[(Z)-octadec-9-enoyl]oxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.1445	uM
(2S)-2-amino-3-[hydroxy-[3-[(Z)-octadec-11-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.1698	uM
(2S)-3-[3-[3-[2-[4-(1-adamantyl)phenoxy]phenyl]propanoyloxy]propoxy-hydroxyphosphoryl]oxy-2-aminopropanoic acid	2008509: Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.1700	uM
(2S)-2-amino-3-[3-[3-[2-(4-tert-butylphenoxy)phenyl]propanoyloxy]propoxy-hydroxyphosphoryl]oxypropanoic acid	2008509: Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.1800	uM
(2S,3S)-2-amino-3-[[(2R)-3-hexadecanoyloxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxybutanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.2100	uM
(2S)-2-amino-3-[hydroxy-[3-[(Z)-octadec-9-enoxy]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.3300	uM
(2S)-2-amino-3-[hydroxy-[3-[3-[2-(4-methylphenoxy)phenyl]propanoyloxy]propoxy]phosphoryl]oxypropanoic acid	2008513: Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 A163F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ec50	0.3500	uM
(2S)-2-amino-3-[hydroxy-[3-[(E)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.4000	uM
(2S)-2-amino-3-[[(2R)-3-[3-(4-heptoxyphenyl)propanoyloxy]-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.4571	uM
(2S)-2-amino-3-[3-dodecanoyloxypropoxy(hydroxy)phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.5200	uM
(2S,3S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[3-(3-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxybutanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.5495	uM
(2S)-2-amino-3-[[2,2-difluoro-3-[(Z)-octadec-9-enoyl]oxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.6456	uM
(2S,3S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-tetradecanoyloxypropoxy]phosphoryl]oxybutanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.7079	uM
(2S)-2-amino-3-[[(2R)-3-dodecanoyloxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	0.9333	uM
(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[[(Z)-octadec-9-enoyl]amino]propoxy]phosphoryl]oxypropanoic acid	1226968: Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ec50	1.1482	uM

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
perfluorooctanoic acid	decreases expression	1
coumarin	increases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	increases expression, increases response to substance	1
Norethindrone Acetate	affects cotreatment, decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Calcitriol	decreases expression	1
Diuron	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Formaldehyde	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Nickel	increases expression	1
Ozone	affects expression, increases abundance	1
Silicon Dioxide	increases expression	1
Dronabinol	decreases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Sodium Selenite	decreases expression	1

ChEMBL screening assays

11 unique, capped per target: 7 binding, 4 functional

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3579720	Binding	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174. — J Med Chem
CHEMBL5362075	Functional	Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	Exploration of LPS2 agonist binding modes using the combination of a new hydrophobic scaffold and homology modeling. — Eur J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.