P3H3

Summary

P3H3 (prolyl 3-hydroxylase 3, HGNC:19318) is a protein-coding gene on chromosome 12p13.31, encoding Prolyl 3-hydroxylase 3 (Q8IVL6). Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils.

The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor.

Source: NCBI Gene 10536 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 68 total
• MANE Select transcript: NM_014262

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19318
Approved symbol	P3H3
Name	prolyl 3-hydroxylase 3
Location	12p13.31
Locus type	gene with protein product
Status	Approved
Aliases	GRCB, HSU47926
Ensembl gene	ENSG00000110811
Ensembl biotype	protein_coding
OMIM	610342
Entrez	10536

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 8 retained_intron, 6 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000290510, ENST00000536140, ENST00000538102, ENST00000540406, ENST00000541956, ENST00000542976, ENST00000544200, ENST00000544813, ENST00000544949, ENST00000545596, ENST00000612048, ENST00000913254, ENST00000942943, ENST00000942944, ENST00000942945, ENST00000942946

RefSeq mRNA: 1 — MANE Select: NM_014262 NM_014262

CCDS: CCDS61027

Canonical transcript exons

ENST00000290510 — 15 exons

Exon	Start	End
ENSE00003716307	6837732	6837849
ENSE00003717606	6831216	6831352
ENSE00003718001	6830353	6830554
ENSE00003719383	6833742	6833809
ENSE00003719454	6839297	6839847
ENSE00003731100	6833925	6834049
ENSE00003733737	6836985	6837086
ENSE00003735096	6830639	6830770
ENSE00003735524	6829859	6830011
ENSE00003736780	6839000	6839140
ENSE00003745173	6837423	6837573
ENSE00003746469	6833592	6833644
ENSE00003750871	6828407	6828938
ENSE00003751035	6831825	6831914
ENSE00003751828	6837958	6838033

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 97.87.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.1124 / max 219.8853, expressed in 1385 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123766	15.9799	1349
123763	3.9989	1051
123762	1.4916	777
123764	0.8672	567
123765	0.4185	268
123767	0.2943	142
206557	0.0562	16
123768	0.0060	1

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	97.87	gold quality
adenohypophysis	UBERON:0002196	96.56	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.54	gold quality
cerebellar hemisphere	UBERON:0002245	95.46	gold quality
cerebellar cortex	UBERON:0002129	95.28	gold quality
body of uterus	UBERON:0009853	95.07	gold quality
pituitary gland	UBERON:0000007	95.06	gold quality
apex of heart	UBERON:0002098	94.45	gold quality
right ovary	UBERON:0002118	94.39	gold quality
ascending aorta	UBERON:0001496	94.20	gold quality
thoracic aorta	UBERON:0001515	94.15	gold quality
descending thoracic aorta	UBERON:0002345	94.12	gold quality
left ovary	UBERON:0002119	93.75	gold quality
endocervix	UBERON:0000458	92.95	gold quality
cerebellum	UBERON:0002037	92.64	gold quality
left uterine tube	UBERON:0001303	92.58	gold quality
right coronary artery	UBERON:0001625	92.28	gold quality
tendon of biceps brachii	UBERON:0008188	91.83	gold quality
left coronary artery	UBERON:0001626	90.84	gold quality
aorta	UBERON:0000947	90.81	gold quality
ectocervix	UBERON:0012249	90.78	gold quality
mucosa of stomach	UBERON:0001199	90.75	gold quality
right atrium auricular region	UBERON:0006631	89.96	gold quality
coronary artery	UBERON:0001621	89.91	gold quality
ovary	UBERON:0000992	88.73	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.67	gold quality
popliteal artery	UBERON:0002250	88.50	gold quality
tibial artery	UBERON:0007610	88.50	gold quality
cardiac atrium	UBERON:0002081	88.02	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.17	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7316	yes	22.80
E-ANND-3	yes	7.61

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting P3H3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-877-3P	99.09	68.10	1637
HSA-MIR-4297	98.77	66.95	2013
HSA-MIR-6852-3P	98.54	67.60	1468
HSA-MIR-6793-3P	97.66	65.78	1084
HSA-MIR-5196-3P	97.57	65.98	979
HSA-MIR-3192-5P	96.98	65.76	1926
HSA-MIR-6759-3P	96.94	68.31	823

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	p3h3	ENSDARG00000057879
mus_musculus	P3h3	ENSMUSG00000023191
rattus_norvegicus	P3h3	ENSRNOG00000071218

Paralogs (2): P3H2 (ENSG00000090530), P3H1 (ENSG00000117385)

Protein

Protein identifiers

Prolyl 3-hydroxylase 3 — Q8IVL6 (reviewed: Q8IVL6)

Alternative names: Leprecan-like protein 2, Protein B

All UniProt accessions (1): Q8IVL6

UniProt curated annotations — full annotation on UniProt →

Function. Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.

Subunit / interactions. Identified in a complex with PLOD1 and P3H4.

Subcellular location. Endoplasmic reticulum.

Tissue specificity. Detected in fetal cartilage (at protein level). Weak expression in heart, lung, ovary and skeletal muscle.

Similarity. Belongs to the leprecan family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8IVL6-1	1	yes
Q8IVL6-2	2

RefSeq proteins (1): NP_055077* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005123	Oxoglu/Fe-dep_dioxygenase_dom	Domain
IPR006620	Pro_4_hyd_alph	Domain
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR039575	P3H	Family
IPR044862	Pro_4_hyd_alph_FE2OG_OXY	Domain
IPR056585	Leprecan_dom	Domain

Pfam: PF13640, PF23557

Enzyme classification (BRENDA):

• EC 1.14.11.28 — proline 3-hydroxylase (BRENDA: 5 organisms, 4 substrates, 14 inhibitors, 11 Km, 1 kcat entries)
• EC 1.14.11.7 — procollagen-proline 3-dioxygenase (BRENDA: 5 organisms, 27 substrates, 31 inhibitors, 8 Km, 0 kcat entries)

Substrate kinetics (BRENDA)

12 substrates with measured Km, best-characterized 12. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
L-PROLINE	0.2–0.56	4
2-OXOGLUTARATE	0.047–0.11	3
L-PIPECOLIC ACID	3.8–100	2
2-OXOGLUTARATE	0.003–0.08	2
3,4-DEHYDRO-L-PROLINE	8.4	1
L-2-AZETIDINECARBOXYLIC ACID	2.1	1
(GLY-L-PRO-L-4-HYDROXYPROLINE)5	0.07	1
L-LEU-L-ASN-GLY-L-LEU-L-4HYP-GLY-L-PRO-L-ILE-GLY	0.26	1
L-PRO-L-THR-GLY-L-PRO-L-ARG-GLY-L-PHE-L-PRO-GLY-	0.07	1
L-SER-L-LYS-GLY-L-GLU-L-GLN-GLY-L-PHE-L-MET-GLY-	0.26	1
O2	0.03	1
PROCOLLAGEN	—	1

Catalyzed reactions (Rhea), 1 shown:

• L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-prolyl-[collagen] + succinate + CO2 (RHEA:22872)

UniProt features (27 total): sequence variant 5, repeat 4, compositionally biased region 3, binding site 3, glycosylation site 2, region of interest 2, signal peptide 1, chain 1, short sequence motif 1, active site 1, splice variant 1, sequence conflict 1, domain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IVL6-F1	81.07	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 666

Ligand- & substrate-binding residues (3): 584; 586; 656

Glycosylation sites (2): 331, 462

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-1650814	Collagen biosynthesis and modifying enzymes

MSigDB gene sets: 134 (showing top): MODULE_416, MYOGENIN_Q6, GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN, PAL_PRMT5_TARGETS_UP, GCANCTGNY_MYOD_Q6, CAGCTG_AP4_Q5, GOBP_PEPTIDYL_LYSINE_MODIFICATION, HIF1_Q3, GOBP_PROTEIN_HYDROXYLATION, DURCHDEWALD_SKIN_CARCINOGENESIS_UP, GOMF_L_ASCORBIC_ACID_BINDING, GOMF_DIOXYGENASE_ACTIVITY, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_16, GOMF_ORGANIC_ACID_BINDING, GOMF_VITAMIN_BINDING

GO Biological Process (4): negative regulation of cell population proliferation (GO:0008285), peptidyl-lysine hydroxylation (GO:0017185), collagen metabolic process (GO:0032963), collagen biosynthetic process (GO:0032964)

GO Molecular Function (8): iron ion binding (GO:0005506), procollagen-proline 3-dioxygenase activity (GO:0019797), L-ascorbic acid binding (GO:0031418), protein binding (GO:0005515), oxidoreductase activity (GO:0016491), oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705), metal ion binding (GO:0046872), dioxygenase activity (GO:0051213)

GO Cellular Component (2): endoplasmic reticulum (GO:0005783), catalytic complex (GO:1902494)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Collagen formation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
oxidoreductase activity	2
cell population proliferation	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
protein hydroxylation	1
peptidyl-lysine modification	1
metabolic process	1
biosynthetic process	1
collagen metabolic process	1
transition metal ion binding	1
procollagen-proline dioxygenase activity	1
peptidyl-proline 3-dioxygenase activity	1
vitamin binding	1
carboxylic acid binding	1
monosaccharide binding	1
heterocyclic compound binding	1
binding	1
catalytic activity	1
cation binding	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1092 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
P3H3	DCN	P07585	964
P3H3	RMDN3	Q96TC7	837
P3H3	CENPB	P07199	715
P3H3	DHRS2	Q13268	703
P3H3	KLRK1	P26718	700
P3H3	SFTPB	P07988	693
P3H3	SFTPC	P11686	666
P3H3	MAF	O75444	657
P3H3	HNRNPR	O43390	652
P3H3	TYRP1	P17643	636
P3H3	FN1	P02751	621
P3H3	BCL2	P10415	621
P3H3	PLG	P00747	595
P3H3	TP53	P04637	591
P3H3	PLOD1	Q02809	562

IntAct

114 interactions, top by confidence:

A	B	Type	Score
C1QTNF9	C1QTNF9B	psi-mi:“MI:0914”(association)	0.780
SOCS7	NCK2	psi-mi:“MI:0914”(association)	0.670
FASLG	PRMT2	psi-mi:“MI:0914”(association)	0.640
ZNF414	AHCYL1	psi-mi:“MI:0914”(association)	0.640
HRG	PLSCR1	psi-mi:“MI:0914”(association)	0.590
OS9	AGRN	psi-mi:“MI:0914”(association)	0.530
P3H3	HSPA8	psi-mi:“MI:0914”(association)	0.530
EMILIN3	ZZEF1	psi-mi:“MI:0914”(association)	0.530
INSL5	COCH	psi-mi:“MI:0914”(association)	0.530
PLAUR	XRCC3	psi-mi:“MI:0914”(association)	0.530
C1QTNF9B	PLOD3	psi-mi:“MI:0914”(association)	0.530
KNG1	CTSV	psi-mi:“MI:0914”(association)	0.530
ADAMTS4	MANBA	psi-mi:“MI:0914”(association)	0.530
C1orf54	EXTL3	psi-mi:“MI:0914”(association)	0.530
IGFBP4	MYCBP2	psi-mi:“MI:0914”(association)	0.530
CRP	QSOX1	psi-mi:“MI:0914”(association)	0.530
PLOD3	PLOD2	psi-mi:“MI:0914”(association)	0.530
PPP1R13L	HSPA8	psi-mi:“MI:0914”(association)	0.530
TAF1C	DNAJA2	psi-mi:“MI:0914”(association)	0.530
COL1A1	GOLIM4	psi-mi:“MI:0914”(association)	0.500
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
	TK2	psi-mi:“MI:0915”(physical association)	0.400
SCGB2A2	GXYLT2	psi-mi:“MI:0914”(association)	0.350
PLAUR	DDX11L8	psi-mi:“MI:0914”(association)	0.350
OLFM4	DDX11L8	psi-mi:“MI:0914”(association)	0.350

BioGRID (121): LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), PLOD1 (Affinity Capture-MS), LEPREL2 (Affinity Capture-MS), KEAP1 (Affinity Capture-MS)

ESM2 similar proteins: A1L515, A4D2P6, A6QQD2, A8VU90, E1BDF2, O75808, O88995, P0CG25, P22083, Q0IIA6, Q2TA57, Q3B7L1, Q3MIP1, Q3U5Q7, Q3UR50, Q3UR97, Q3UV16, Q400G9, Q5BKX5, Q5EBM0, Q5GH72, Q5SZI1, Q5TM19, Q5U4P2, Q62994, Q659K9, Q6PRD1, Q7Z736, Q861W0, Q86UR1, Q8BNN1, Q8C0R7, Q8CG70, Q8IUW3, Q8IVL6, Q8N398, Q8NAG6, Q8NCW0, Q8R2H1, Q8VCE9

Diamond homologs: O75718, Q32P28, Q3V1T4, Q4KLM6, Q64375, Q6JHU7, Q6JHU8, Q6PK18, Q8CG70, Q8CG71, Q8IVL5, Q8IVL6, Q8K2B0, Q90830, Q92791, Q9CYD3, Q9R1J8, Q5M843, Q5XGE0, Q9D136

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 133 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Collagen biosynthesis and modifying enzymes	7	12.7×	3e-04

GO biological processes:

GO term	Partners	Fold	FDR
collagen fibril organization	8	15.8×	4e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2498 predictions. Top by Δscore:

Variant	Effect	Δscore
12:6829848:C:CA	acceptor_gain	1.0000
12:6829855:TCA:T	acceptor_loss	1.0000
12:6829857:A:AG	acceptor_gain	1.0000
12:6829857:AGTT:A	acceptor_gain	1.0000
12:6829858:G:GT	acceptor_gain	1.0000
12:6829858:GT:G	acceptor_gain	1.0000
12:6829858:GTT:G	acceptor_gain	1.0000
12:6829858:GTTG:G	acceptor_gain	1.0000
12:6829858:GTTGA:G	acceptor_gain	1.0000
12:6829943:GC:G	donor_gain	1.0000
12:6830010:GG:G	donor_gain	1.0000
12:6830011:GG:G	donor_gain	1.0000
12:6830012:G:GC	donor_loss	1.0000
12:6830012:G:GG	donor_gain	1.0000
12:6830013:T:G	donor_loss	1.0000
12:6830350:CAG:C	acceptor_loss	1.0000
12:6830351:A:AG	acceptor_gain	1.0000
12:6830351:A:T	acceptor_loss	1.0000
12:6830352:G:GA	acceptor_loss	1.0000
12:6830352:G:GG	acceptor_gain	1.0000
12:6830352:GGCA:G	acceptor_gain	1.0000
12:6830552:CAGGT:C	donor_loss	1.0000
12:6830553:AGG:A	donor_loss	1.0000
12:6830554:GGTA:G	donor_loss	1.0000
12:6830555:G:GC	donor_loss	1.0000
12:6830740:C:G	donor_gain	1.0000
12:6830769:GG:G	donor_gain	1.0000
12:6830770:GG:G	donor_gain	1.0000
12:6831214:A:AG	acceptor_gain	1.0000
12:6831214:AGT:A	acceptor_gain	1.0000

AlphaMissense

4693 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:6837758:A:C	S580R	0.997
12:6837760:T:A	S580R	0.997
12:6837760:T:G	S580R	0.997
12:6838005:T:C	F626S	0.996
12:6838005:T:G	F626C	0.996
12:6839110:G:C	W672C	0.995
12:6839110:G:T	W672C	0.995
12:6829898:T:C	F180L	0.993
12:6829900:C:A	F180L	0.993
12:6829900:C:G	F180L	0.993
12:6839036:T:C	F648L	0.993
12:6839038:C:A	F648L	0.993
12:6839038:C:G	F648L	0.993
12:6837782:T:A	C588S	0.992
12:6837783:G:C	C588S	0.992
12:6828570:G:T	G44W	0.991
12:6837550:T:C	L563P	0.991
12:6839025:G:C	R644P	0.991
12:6839060:C:G	H656D	0.991
12:6837540:T:C	F560L	0.990
12:6837542:C:A	F560L	0.990
12:6837542:C:G	F560L	0.990
12:6839028:T:C	L645P	0.990
12:6837777:A:T	D586V	0.989
12:6839108:T:A	W672R	0.989
12:6839108:T:C	W672R	0.989
12:6828571:G:A	G44E	0.988
12:6837783:G:A	C588Y	0.988
12:6837784:C:G	C588W	0.988
12:6837840:G:C	R607P	0.988

dbSNP variants (sampled 300 via entrez): RS1000061715 (12:6829050 T>A), RS1000633921 (12:6830301 C>T), RS1001117334 (12:6836634 C>G,T), RS1002497738 (12:6836769 C>G,T), RS1002774305 (12:6827749 A>G), RS1002947990 (12:6834103 C>A,G,T), RS1003215409 (12:6827561 G>A), RS1003286664 (12:6839006 G>A,C,T), RS1003288243 (12:6832561 C>T), RS1003320609 (12:6832289 C>T), RS1003904844 (12:6837619 C>A,T), RS1004325225 (12:6839491 C>T), RS1004340210 (12:6839219 T>C), RS1004491595 (12:6834188 G>A), RS1004644248 (12:6827019 C>G,T)

Disease associations

OMIM: gene MIM:610342 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001450_2	Response to Vitamin E supplementation	4.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs5441	Efficacy	3	sertraline	Major Depressive Disorder

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs5441	GNB3, P3H3	3	2.75	1	sertraline

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases methylation	3
sodium arsenite	decreases expression, increases abundance	2
Benzo(a)pyrene	affects methylation, increases methylation	2
aristolochic acid I	decreases expression	1
bisphenol A	decreases expression	1
cobaltous chloride	decreases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	increases abundance, decreases expression	1
benzo(e)pyrene	decreases methylation	1
perfluorooctane sulfonic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
jinfukang	increases expression, affects cotreatment	1
Temozolomide	affects response to substance	1
Sunitinib	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	increases abundance, decreases expression	1
Carmustine	affects response to substance	1
Cisplatin	affects cotreatment, increases expression	1
Copper	affects binding, increases expression	1
Disulfiram	affects binding, increases expression	1
Doxorubicin	increases expression	1
Estradiol	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Manganese	decreases expression, increases abundance	1
Methapyrilene	decreases methylation	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.