PABPC1L

Summary

PABPC1L (poly(A) binding protein cytoplasmic 1 like, HGNC:15797) is a protein-coding gene on chromosome 20q13.12, encoding Polyadenylate-binding protein 1-like (Q4VXU2). Poly(A)-binding protein involved in oocyte maturation and early embryo development.

This gene belongs to the polyadenylate-binding protein type-1 family of proteins. Members of this family bind to the polyA tails of mRNAs to regulate mRNA stability and translation. The mouse ortholog of this gene is required for female fertility. In human, expression of a functional protein is regulated by alternative splicing. The protein-coding splice variant for this gene is abundantly expressed in human oocytes, while a noncoding splice variant subject to nonsense-mediated decay is the predominant splice variant expressed in somatic tissues.

Source: NCBI Gene 80336 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 121 total — 10 pathogenic
• Phenotypes (HPO): 7
• MANE Select transcript: NM_001372179

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15797
Approved symbol	PABPC1L
Name	poly(A) binding protein cytoplasmic 1 like
Location	20q13.12
Locus type	gene with protein product
Status	Approved
Aliases	dJ1069P2.3, PABPC1L1, ePAB
Ensembl gene	ENSG00000101104
Ensembl biotype	protein_coding
OMIM	621055
Entrez	80336

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 7 protein_coding, 6 nonsense_mediated_decay, 4 retained_intron, 4 protein_coding_CDS_not_defined

ENST00000217073, ENST00000217074, ENST00000217075, ENST00000255136, ENST00000372819, ENST00000372822, ENST00000372824, ENST00000372826, ENST00000465761, ENST00000474208, ENST00000476056, ENST00000479873, ENST00000482486, ENST00000489068, ENST00000490798, ENST00000537323, ENST00000674244, ENST00000674318, ENST00000674382, ENST00000925475, ENST00000925476

RefSeq mRNA: 1 — MANE Select: NM_001372179 NM_001372179

CCDS: CCDS42878

Canonical transcript exons

ENST00000217073 — 15 exons

Exon	Start	End
ENSE00001595311	44932342	44932432
ENSE00001621477	44918906	44919045
ENSE00001693471	44912660	44912853
ENSE00001699543	44939126	44939316
ENSE00001710510	44919183	44919277
ENSE00001742943	44916756	44916871
ENSE00001791300	44921594	44921731
ENSE00002726568	44910060	44910336
ENSE00003504366	44938061	44938191
ENSE00003515430	44924161	44924256
ENSE00003530364	44936637	44936730
ENSE00003553535	44938674	44938748
ENSE00003625899	44935391	44935497
ENSE00003647159	44930460	44930726
ENSE00003898634	44933057	44933185

Expression profiles

Bgee: expression breadth ubiquitous, 210 present calls, max score 96.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1069 / max 232.4783, expressed in 1481 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
184762	8.1067	1461
184763	0.5007	273
184764	0.4995	261

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	96.37	gold quality
right lobe of liver	UBERON:0001114	96.26	gold quality
left lobe of thyroid gland	UBERON:0001120	96.26	gold quality
right lobe of thyroid gland	UBERON:0001119	95.98	gold quality
right uterine tube	UBERON:0001302	95.95	gold quality
metanephros cortex	UBERON:0010533	95.53	gold quality
thyroid gland	UBERON:0002046	95.25	gold quality
adenohypophysis	UBERON:0002196	93.89	gold quality
lower esophagus mucosa	UBERON:0035834	93.38	gold quality
left ovary	UBERON:0002119	93.13	gold quality
right ovary	UBERON:0002118	92.91	gold quality
pituitary gland	UBERON:0000007	92.89	gold quality
pancreatic ductal cell	CL:0002079	92.78	silver quality
granulocyte	CL:0000094	91.99	gold quality
metanephros	UBERON:0000081	91.35	gold quality
body of stomach	UBERON:0001161	90.94	gold quality
spleen	UBERON:0002106	90.84	gold quality
oocyte	CL:0000023	90.78	gold quality
cortex of kidney	UBERON:0001225	90.47	gold quality
upper lobe of left lung	UBERON:0008952	90.45	gold quality
upper arm skin	UBERON:0004263	90.32	gold quality
stromal cell of endometrium	CL:0002255	90.13	gold quality
minor salivary gland	UBERON:0001830	90.13	gold quality
mucosa of transverse colon	UBERON:0004991	89.66	gold quality
descending thoracic aorta	UBERON:0002345	89.53	gold quality
small intestine Peyer’s patch	UBERON:0003454	89.47	gold quality
right lung	UBERON:0002167	89.42	gold quality
ascending aorta	UBERON:0001496	89.32	gold quality
right adrenal gland cortex	UBERON:0035827	89.29	gold quality
thoracic aorta	UBERON:0001515	89.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Human EPAB mRNA is detected in ovaries, testes and several somatic tissues including pancreas, liver and thymus, and EPAB is the predominant poly(A) binding protein in immature (germinal vesicle) and mature (metaphase II) oocytes. (PMID:18716053)
• EPAB decreased expression in in infertile men with non-obstructive azoospermia (PMID:26843391)
• Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility. (PMID:37723834)
• Pathogenic missense variation in PABPC1L/EPAB causes female infertility due to oocyte maturation arrest at the germinal vesicle stage. (PMID:38177974)
• PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma. (PMID:38382068)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	pabpc1l	ENSDARG00000002597
mus_musculus	Pabpc1l	ENSMUSG00000054582
rattus_norvegicus	Pabpc1l	ENSRNOG00000012750

Paralogs (24): ELAVL1 (ENSG00000066044), PABPC1 (ENSG00000070756), RBMS2 (ENSG00000076067), PABPC4 (ENSG00000090621), ELAVL2 (ENSG00000107105), RBM24 (ENSG00000112183), TARDBP (ENSG00000120948), HNRNPR (ENSG00000125944), RBM38 (ENSG00000132819), SYNCRIP (ENSG00000135316), SF3B4 (ENSG00000143368), RBMS3 (ENSG00000144642), PABPC3 (ENSG00000151846), RBMS1 (ENSG00000153250), RBM45 (ENSG00000155636), ELAVL4 (ENSG00000162374), PABPC5 (ENSG00000174740), PUF60 (ENSG00000179950), PABPC1L2B (ENSG00000184388), PABPC1L2A (ENSG00000186288), RBM34 (ENSG00000188739), ELAVL3 (ENSG00000196361), RBM14 (ENSG00000239306), PABPC4L (ENSG00000254535)

Protein

Protein identifiers

Polyadenylate-binding protein 1-like — Q4VXU2 (reviewed: Q4VXU2)

Alternative names: Embryonic poly(A)-binding protein, Poly(A) binding protein cytoplasmic 1 like

All UniProt accessions (10): Q4VXU2, A0A6I8PIK9, A0A6I8PL98, A0A6I8PLA1, A0A6I8PS38, A0A6Q8JFT6, A0A6Q8JFV4, H0Y386, Q4VXT5, Q4VXT8

UniProt curated annotations — full annotation on UniProt →

Function. Poly(A)-binding protein involved in oocyte maturation and early embryo development. It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes.

Subcellular location. Cytoplasm.

Tissue specificity. Expressed in ovary and testis. Also expressed in pancreas, liver and thymus, and at lower levels in other somatic tissues including brain and lung.

Disease relevance. Oocyte/zygote/embryo maturation arrest 22 (OZEMA22) [MIM:621093] An autosomal recessive, female infertility disorder characterized by oocyte maturation arrest, primarily at the germinal vesicle or metaphase I stages. In some cases, oocyte reaching the metaphase II stage can be fertilized, but embryo development is arrested before the 4-cell stage. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the polyadenylate-binding protein type-1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q4VXU2-1	1	yes
Q4VXU2-2	2

RefSeq proteins (1): NP_001359108* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000504	RRM_dom	Domain
IPR002004	PABP_HYD_C	Domain
IPR003954	RRM_euk-type	Domain
IPR006515	PABP_1234	Family
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR034364	PABP_RRM1	Domain
IPR035979	RBD_domain_sf	Homologous_superfamily
IPR036053	PABP-dom	Homologous_superfamily
IPR045305	RRM2_I_PABPs	Domain

Pfam: PF00076, PF00658

UniProt features (19 total): sequence variant 10, domain 5, splice variant 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q4VXU2-F1	76.41	0.41

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 91 (showing top): GOBP_OOGENESIS, GOBP_TRANSLATION, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_ANATOMICAL_STRUCTURE_MATURATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_CELL_MATURATION, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM, GOBP_OOCYTE_MATURATION, GOBP_OOCYTE_DIFFERENTIATION, GOBP_FEMALE_GAMETE_GENERATION, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOBP_POSITIVE_REGULATION_OF_TRANSLATION, GOCC_CYTOPLASMIC_STRESS_GRANULE, GOBP_REGULATION_OF_TRANSLATION

GO Biological Process (6): oocyte maturation (GO:0001556), positive regulation of translation (GO:0045727), cell differentiation (GO:0030154), oogenesis (GO:0048477), regulation of macromolecule metabolic process (GO:0060255), regulation of primary metabolic process (GO:0080090)

GO Molecular Function (5): mRNA 3’-UTR binding (GO:0003730), poly(A) binding (GO:0008143), poly(U) RNA binding (GO:0008266), nucleic acid binding (GO:0003676), RNA binding (GO:0003723)

GO Cellular Component (6): nucleus (GO:0005634), cytosol (GO:0005829), cytoplasmic stress granule (GO:0010494), extracellular exosome (GO:0070062), ribonucleoprotein complex (GO:1990904), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of metabolic process	2
cellular anatomical structure	2
developmental process involved in reproduction	1
cell maturation	1
oocyte development	1
translation	1
regulation of translation	1
positive regulation of gene expression	1
positive regulation of protein metabolic process	1
cellular developmental process	1
germ cell development	1
female gamete generation	1
macromolecule metabolic process	1
primary metabolic process	1
mRNA binding	1
poly-purine tract binding	1
poly-pyrimidine tract binding	1
binding	1
nucleic acid binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
cytoplasmic ribonucleoprotein granule	1
extracellular vesicle	1
protein-containing complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1662 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PABPC1L	PABPN1	Q86U42	870
PABPC1L	EIF4G1	Q04637	798
PABPC1L	CPEB1	Q9BZB8	762
PABPC1L	TENT2	Q6PIY7	719
PABPC1L	EIF4E	P06730	703
PABPC1L	PARN	O95453	680
PABPC1L	SYMPK	Q92797	654
PABPC1L	EIF4E1B	A6NMX2	648
PABPC1L	EIF4A1	P04765	642
PABPC1L	EIF4A2	Q14240	642
PABPC1L	DDX6	P26196	634
PABPC1L	LSM14B	Q9BX40	616
PABPC1L	PNLDC1	Q8NA58	602
PABPC1L	TNRC6A	Q8NDV7	601
PABPC1L	PAN2	Q504Q3	554
PABPC1L	PAIP2	Q9BPZ3	554

IntAct

19 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
PAIP2B	CASC3	psi-mi:“MI:0914”(association)	0.530
GSPT2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
NP	HNRNPCL1	psi-mi:“MI:0914”(association)	0.350
PAIP1	H2AX	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
ESR2		psi-mi:“MI:0914”(association)	0.350
GCM1	LONP1	psi-mi:“MI:0914”(association)	0.350
PABPC5	APOBEC3DE	psi-mi:“MI:0914”(association)	0.350
PAIP1	CASC3	psi-mi:“MI:0914”(association)	0.350
ESR1	TUBAL3	psi-mi:“MI:0914”(association)	0.350

BioGRID (48): PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-RNA), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS), PABPC1L (Affinity Capture-MS)

ESM2 similar proteins: A2A5N3, F1QB54, F4HT49, G5EFS2, O04319, O22173, O43347, O64380, P11940, P20965, P21187, P29341, P31209, P42731, P61286, P70318, P86049, Q05196, Q08BH5, Q0P4R6, Q13310, Q22708, Q4VXU2, Q503H1, Q54BM2, Q5R8F7, Q5R9H4, Q5YD48, Q61474, Q6DCB7, Q6DEY7, Q6GR16, Q6IP09, Q6IQE0, Q7T1H5, Q8GZ26, Q8K3P4, Q8LFS6, Q8TBY0, Q920Q6

Diamond homologs: A0A0D1DWZ5, A0JM51, A1CRM1, A1D4K4, A2A5N3, A2Q848, A3LXL0, A4IIM2, A4QUF0, A5DW14, F4HT49, O04319, O14102, O22173, O57406, O64380, O95319, O97018, P04147, P0CB38, P0CP46, P0CP47, P20965, P21187, P28659, P29558, P31209, P32588, P39697, P42731, P60047, P60048, P60049, P60050, Q08E07, Q09442, Q0CR95, Q0U1G2, Q13310, Q15427

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

121 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	10
Likely pathogenic	0
Uncertain significance	84
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (10)

Variant ID	HGVS	Classification
1172840	NM_001372179.1(PABPC1L):c.1037C>T (p.Ala346Val)	Pathogenic
3602609	NM_001372179.1(PABPC1L):c.290G>A (p.Gly97Asp)	Pathogenic
3602610	NM_001372179.1(PABPC1L):c.526C>T (p.Arg176Ter)	Pathogenic
3602611	NM_001372179.1(PABPC1L):c.958dup (p.Ile320fs)	Pathogenic
3602612	NM_001372179.1(PABPC1L):c.410C>T (p.Ser137Phe)	Pathogenic
3602613	NM_001372179.1(PABPC1L):c.1121G>A (p.Arg374Gln)	Pathogenic
3602614	NM_001372179.1(PABPC1L):c.536G>A (p.Arg179Gln)	Pathogenic
3602615	NM_001372179.1(PABPC1L):c.793C>T (p.Arg265Trp)	Pathogenic
3602616	NM_001372179.1(PABPC1L):c.1201C>T (p.Gln401Ter)	Pathogenic
3602617	A346V	Pathogenic

SpliceAI

3683 predictions. Top by Δscore:

Variant	Effect	Δscore
20:44910333:GACG:G	donor_gain	1.0000
20:44910334:ACGGT:A	donor_loss	1.0000
20:44910335:CGGT:C	donor_loss	1.0000
20:44910336:GGT:G	donor_loss	1.0000
20:44910337:G:GG	donor_gain	1.0000
20:44910337:GTGAG:G	donor_loss	1.0000
20:44910338:T:A	donor_loss	1.0000
20:44912653:T:A	acceptor_gain	1.0000
20:44912654:GTCCA:G	acceptor_loss	1.0000
20:44912655:TCCAG:T	acceptor_loss	1.0000
20:44912656:CCAGC:C	acceptor_loss	1.0000
20:44912657:CAGCG:C	acceptor_loss	1.0000
20:44912658:A:AG	acceptor_gain	1.0000
20:44912658:AG:A	acceptor_loss	1.0000
20:44912658:AGC:A	acceptor_gain	1.0000
20:44912658:AGCG:A	acceptor_gain	1.0000
20:44912659:G:GT	acceptor_gain	1.0000
20:44912659:GC:G	acceptor_gain	1.0000
20:44912659:GCG:G	acceptor_gain	1.0000
20:44912659:GCGG:G	acceptor_gain	1.0000
20:44912659:GCGGA:G	acceptor_gain	1.0000
20:44912661:G:A	acceptor_gain	1.0000
20:44912806:GCTT:G	donor_gain	1.0000
20:44912850:CAAGG:C	donor_loss	1.0000
20:44912851:AAG:A	donor_loss	1.0000
20:44912852:AG:A	donor_loss	1.0000
20:44912853:GG:G	donor_loss	1.0000
20:44912854:GTAGA:G	donor_loss	1.0000
20:44912855:T:G	donor_loss	1.0000
20:44916870:GT:G	donor_gain	1.0000

AlphaMissense

4055 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:44916796:T:A	V143D	1.000
20:44924181:G:C	K299N	1.000
20:44924181:G:T	K299N	1.000
20:44930490:T:C	F335L	1.000
20:44930492:T:A	F335L	1.000
20:44930492:T:G	F335L	1.000
20:44930496:T:C	F337L	1.000
20:44930498:T:A	F337L	1.000
20:44930498:T:G	F337L	1.000
20:44916790:G:A	G141D	0.999
20:44916792:T:C	F142L	0.999
20:44916794:T:A	F142L	0.999
20:44916794:T:G	F142L	0.999
20:44924171:T:G	L296W	0.999
20:44924173:T:G	Y297D	0.999
20:44924177:T:A	V298E	0.999
20:44924179:A:G	K299E	0.999
20:44924184:T:A	N300K	0.999
20:44924184:T:G	N300K	0.999
20:44924213:T:C	L310P	0.999
20:44924224:T:C	F314L	0.999
20:44924225:T:C	F314S	0.999
20:44924226:C:A	F314L	0.999
20:44924226:C:G	F314L	0.999
20:44924237:G:A	G318E	0.999
20:44930494:G:A	G336D	0.999
20:44930497:T:C	F337S	0.999
20:44930497:T:G	F337C	0.999
20:44930500:T:A	V338E	0.999
20:44930590:C:A	A368D	0.999

dbSNP variants (sampled 300 via entrez): RS1000083379 (20:44928237 A>T), RS1000089307 (20:44916116 G>A), RS1000114583 (20:44927936 G>A), RS1000160191 (20:44914506 C>CATG), RS1000220458 (20:44937332 C>A,T), RS1000261530 (20:44917189 G>A,T), RS1000472941 (20:44922600 A>G), RS1000537729 (20:44910628 C>G), RS1000792824 (20:44934181 T>C), RS1001004140 (20:44928369 G>A), RS1001051874 (20:44910289 G>A), RS1001248942 (20:44917777 G>A,T), RS1001362876 (20:44917458 A>G), RS1001379593 (20:44939657 T>C), RS1001500048 (20:44917345 C>T)

Disease associations

OMIM: gene MIM:621055 | disease phenotypes: MIM:615774, MIM:621093

GenCC curated gene-disease

Mondo (2): female infertility due to zona pellucida defect (MONDO:0014342), oocyte/zygote/embryo maturation arrest 22 (MONDO:0976137)

Orphanet (1): Female infertility due to zona pellucida defect (Orphanet:404466)

HPO phenotypes

7 total (7 of 7 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0008222	Female infertility
HP:0011462	Young adult onset
HP:0025708	Early young adult onset
HP:0031516	Metaphase I oocyte maturation arrest
HP:0033712	Repeated implantation failure
HP:0034914	Oocyte maturation arrest

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST004618_52	White blood cell count (basophil)	7.000000e-09
GCST006947_59	Feeling fed-up	1.000000e-08
GCST007565_171	Morning person	4.000000e-15
GCST007576_251	Chronotype	4.000000e-15
GCST008103_18	Bipolar disorder	1.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0005090	basophil count
EFO:0009588	feeling “fed-up” measurement
EFO:0008328	chronotype measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	4
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	3
bisphenol F	affects cotreatment, increases methylation, decreases expression	2
bisphenol A	affects expression, decreases methylation	2
Air Pollutants	affects expression, increases abundance, increases expression	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
Benzo(a)pyrene	decreases methylation, increases expression	2
Silicon Dioxide	increases expression, decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Valproic Acid	increases expression	2
Cadmium Chloride	decreases expression, increases abundance	2
Particulate Matter	increases abundance, increases expression, affects cotreatment, affects expression, decreases expression	2
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
trichostatin A	increases expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	increases expression	1
isobutyl alcohol	increases abundance, affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	increases expression	1
jinfukang	affects cotreatment, increases expression	1
NSC 689534	affects binding, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Ethanol	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.