PACERR

Summary

PACERR (PTGS2 antisense NFKB1 complex-mediated expression regulator RNA, HGNC:50552) is a long non-coding RNA gene on chromosome 1q31.1.

This gene represents transcription of a long non-coding RNA produced in antisense to the prostaglandin-endoperoxide synthase 2 (PTGS2) gene. This transcript interacts with NF-kB transcriptional regulators to promote expression of PTGS2.

Source: NCBI Gene 103752588 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50552
Approved symbol	PACERR
Name	PTGS2 antisense NFKB1 complex-mediated expression regulator RNA
Location	1q31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	PACER, PTGS2-AS1
Ensembl gene	ENSG00000273129
Ensembl biotype	lncRNA
OMIM	617650
Entrez	103752588
RNAcentral	URS00007E42F7 — lncRNA, 793 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000608917

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000608917 — 1 exons

Exon	Start	End
ENSE00004219548	186680108	186683165

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 73.71.

FANTOM5 (CAGE): breadth broad, TPM avg 2.4273 / max 181.5289, expressed in 592 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
7367	1.3034	377
7366	0.6074	183
7368	0.3762	141
7365	0.1403	48

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	73.71	gold quality
prostate gland	UBERON:0002367	69.30	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.79	gold quality
right uterine tube	UBERON:0001302	68.65	gold quality
urinary bladder	UBERON:0001255	66.54	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.62	gold quality
granulocyte	CL:0000094	65.58	gold quality
right coronary artery	UBERON:0001625	65.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.93	gold quality
lower esophagus	UBERON:0013473	64.88	gold quality
popliteal artery	UBERON:0002250	64.82	gold quality
tibial artery	UBERON:0007610	64.77	gold quality
left coronary artery	UBERON:0001626	64.65	gold quality
lower esophagus mucosa	UBERON:0035834	64.47	gold quality
fundus of stomach	UBERON:0001160	63.32	gold quality
endocervix	UBERON:0000458	62.65	gold quality
bone marrow	UBERON:0002371	61.78	gold quality
colon	UBERON:0001155	61.34	gold quality
ectocervix	UBERON:0012249	61.17	gold quality
vagina	UBERON:0000996	60.83	gold quality
gall bladder	UBERON:0002110	60.20	gold quality
right atrium auricular region	UBERON:0006631	60.16	gold quality
ascending aorta	UBERON:0001496	60.06	gold quality
superior frontal gyrus	UBERON:0002661	59.48	gold quality
thoracic aorta	UBERON:0001515	59.45	gold quality
descending thoracic aorta	UBERON:0002345	59.40	gold quality
metanephros cortex	UBERON:0010533	59.39	gold quality
leukocyte	CL:0000738	59.23	gold quality
myometrium	UBERON:0001296	58.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Findings suggest that P50-associated COX-2 extragenic RNA (PACER) promotes proliferation and metastasis of osteosarcoma cells by activating the cyclooxygenase-2 (COX-2) gene and its own expression was influenced by DNA methylation. (PMID:26476537)
• Therefore, lncRNA PACER is down-regulated in OA and regulates chondrocyte apoptosis by down-regulating lncRNA HOTAIR. (PMID:31113870)
• PACER lncRNA regulates COX-2 expression in lung cancer cells. (PMID:35136486)
• LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. (PMID:35526050)
• Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients. (PMID:38395324)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.