PAGE2

Summary

PAGE2 (PAGE family member 2, HGNC:31804) is a protein-coding gene on chromosome Xp11.21, encoding P antigen family member 2 (Q7Z2X7).

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 23 total — 1 likely-pathogenic
• MANE Select transcript: NM_207339

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31804
Approved symbol	PAGE2
Name	PAGE family member 2
Location	Xp11.21
Locus type	gene with protein product
Status	Approved
Aliases	MGC62094, PAGE-2, CT16.4
Ensembl gene	ENSG00000234068
Ensembl biotype	protein_coding
OMIM	300738
Entrez	203569

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000374965, ENST00000374968, ENST00000449097

RefSeq mRNA: 1 — MANE Select: NM_207339 NM_207339

CCDS: CCDS14367

Canonical transcript exons

ENST00000374968 — 5 exons

Exon	Start	End
ENSE00001601750	55089018	55089103
ENSE00001610680	55091332	55091457
ENSE00001719761	55092715	55092842
ENSE00001801056	55090013	55090104
ENSE00003784542	55090502	55090610

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 94.36.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1398 / max 81.3784, expressed in 17 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196455	0.1050	17
196456	0.0182	8
196457	0.0165	6

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.36	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.72	gold quality
right testis	UBERON:0004534	89.22	gold quality
testis	UBERON:0000473	88.12	gold quality
left testis	UBERON:0004533	87.17	gold quality
placenta	UBERON:0001987	51.65	gold quality
mucosa of stomach	UBERON:0001199	47.07	gold quality
granulocyte	CL:0000094	46.68	silver quality
bone marrow cell	CL:0002092	45.87	gold quality
blood	UBERON:0000178	44.87	gold quality
left coronary artery	UBERON:0001626	43.15	gold quality
cortical plate	UBERON:0005343	43.11	gold quality
bone marrow	UBERON:0002371	42.20	gold quality
skin of leg	UBERON:0001511	40.66	gold quality
zone of skin	UBERON:0000014	40.40	gold quality
cerebellar hemisphere	UBERON:0002245	40.30	silver quality
left ovary	UBERON:0002119	40.16	gold quality
skin of abdomen	UBERON:0001416	40.14	gold quality
cerebellar cortex	UBERON:0002129	40.01	silver quality
cerebellum	UBERON:0002037	39.74	silver quality
ovary	UBERON:0000992	39.55	gold quality
spleen	UBERON:0002106	39.02	gold quality
right uterine tube	UBERON:0001302	38.76	silver quality
tibial artery	UBERON:0007610	38.50	gold quality
popliteal artery	UBERON:0002250	38.31	gold quality
ganglionic eminence	UBERON:0004023	37.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	37.22	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
right ovary	UBERON:0002118	36.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	36.62	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-6308	yes	938.92
E-ENAD-20	yes	204.05
E-GEOD-134144	yes	31.49
E-GEOD-110499	no	120.59
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting PAGE2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-3123	99.47	67.15	2693
HSA-MIR-6507-5P	99.36	70.46	2524
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-488-5P	99.28	68.12	821
HSA-MIR-4477A	98.83	69.75	2952

Literature-anchored findings (GeneRIF, showing 1)

• Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition (PMID:25229454)

Cross-species orthologs

0 orthologs

Paralogs (22): PAGE1 (ENSG00000068985), PAGE4 (ENSG00000101951), XAGE2 (ENSG00000155622), PAGE5 (ENSG00000158639), XAGE3 (ENSG00000171402), XAGE5 (ENSG00000171405), GAGE2A (ENSG00000189064), PAGE3 (ENSG00000204279), XAGE1A (ENSG00000204379), XAGE1B (ENSG00000204382), GAGE1 (ENSG00000205777), GAGE12G (ENSG00000215269), GAGE10 (ENSG00000215274), GAGE12E (ENSG00000216649), GAGE12J (ENSG00000224659), GAGE12H (ENSG00000224902), GAGE12D (ENSG00000227488), GAGE12F (ENSG00000236362), GAGE12C (ENSG00000237671), PAGE2B (ENSG00000238269), GAGE13 (ENSG00000274274), GAGE2E (ENSG00000275113)

Protein

Protein identifiers

P antigen family member 2 — Q7Z2X7 (reviewed: Q7Z2X7)

Alternative names: G antigen family C 2, Prostate-associated gene 2 protein

All UniProt accessions (3): Q7Z2X7, X6R922, X6RD31

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the GAGE family.

RefSeq proteins (1): NP_997222* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008625	GAGE_fam	Family
IPR031320	GAGE	Domain

Pfam: PF05831

UniProt features (4 total): chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z2X7-F1	61.33	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 8 (showing top): BIDUS_METASTASIS_UP, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, chrXp11, MIR5582_3P, MIR4477A, MIR3180_5P, SU_HO_CONV_CENT_CHONDROSARCOMA_LEUKOCYTE_C4_OSTEOCLAST, NEWMAN_ERCC6_TARGETS_DN

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

64 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PAGE2	PAGE1	O75459	945
PAGE2	SPANXA1	Q9NS26	436
PAGE2	SPANXD	Q9BXN6	378
PAGE2	SPANXB1	Q9NS25	353
PAGE2	MOB2	Q70IA6	327
PAGE2	CTAG2	O75638	250
PAGE2	MAGEB3	O15480	244
PAGE2	PAGE4	O60829	219
PAGE2	ENTREP3	P81408	215
PAGE2	MAGEB2	O15479	204
PAGE2	TGM1	P22735	202
PAGE2	APOL5	Q9BWW9	201
PAGE2	TP53RK	Q96S44	199
PAGE2	TPRKB	Q9Y3C4	198
PAGE2	KPNA4	O00629	198

IntAct

13 interactions, top by confidence:

A	B	Type	Score
PAGE2	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
MEOX2	PAGE2	psi-mi:“MI:0915”(physical association)	0.560
TINF2	PAGE2	psi-mi:“MI:0915”(physical association)	0.510
PAGE2	PAGE5	psi-mi:“MI:0915”(physical association)	0.400
PAGE2	HSP90AB4P	psi-mi:“MI:0915”(physical association)	0.400
ZBTB8OS	PAGE2	psi-mi:“MI:0915”(physical association)	0.400
TERF1	PAGE2	psi-mi:“MI:0915”(physical association)	0.370
ACD	PAGE2	psi-mi:“MI:0915”(physical association)	0.370
POT1	PAGE2	psi-mi:“MI:0915”(physical association)	0.370
SHLD3		psi-mi:“MI:0914”(association)	0.350
PAGE2	TINF2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): PAGE2 (Two-hybrid), PAGE5 (Affinity Capture-MS), PAGE2 (Affinity Capture-MS), HSP90AB4P (Affinity Capture-MS), PAGE2 (Two-hybrid), PAGE2 (Two-hybrid), PAGE2 (Two-hybrid), PAGE2 (Two-hybrid)

ESM2 similar proteins: A0A0U1RQG5, A1L429, A6NDE8, A6NER3, A6NGK3, E1AZ71, O08664, O60829, O75459, O76087, P0C2W7, P0CL80, P0CL81, P0CL82, P0DSO3, P0DTW1, P52651, P62521, P86478, P86479, P86480, P86481, P86496, Q13066, Q13069, Q13070, Q17QW4, Q28181, Q2T9P9, Q32PA2, Q4V321, Q4V326, Q5JQC4, Q5U2Y8, Q62100, Q63803, Q64256, Q6NT46, Q6X7S9, Q7Z2X7

Diamond homologs: O75459, Q5JRK9, Q5JUK9, Q7Z2X7, Q8WTP9, Q8WWM1, Q96GT9, Q96GU1, A6NGK3, A1L429, A6NDE8, A6NER3, O76087, P0CL80, P0CL81, P0CL82, P0DSO3, P0DTW1, Q13066, Q13069, Q13070, Q4V321, Q4V326, Q6NT46, Q9UEU5, Q9HD64

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	13
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1526799	GRCh37/hg19 Xp11.22-11.21(chrX:52881435-55684871)	Likely pathogenic

SpliceAI

552 predictions. Top by Δscore:

Variant	Effect	Δscore
X:55089100:GCCG:G	donor_gain	1.0000
X:55090011:A:AG	acceptor_gain	1.0000
X:55090011:AGT:A	acceptor_gain	1.0000
X:55090011:AGTG:A	acceptor_gain	1.0000
X:55090012:G:GA	acceptor_gain	1.0000
X:55090012:GT:G	acceptor_gain	1.0000
X:55090012:GTG:G	acceptor_gain	1.0000
X:55090012:GTGG:G	acceptor_gain	1.0000
X:55090101:GATT:G	donor_gain	1.0000
X:55090105:G:GG	donor_gain	1.0000
X:55090617:G:GT	donor_gain	1.0000
X:55090619:A:T	donor_gain	1.0000
X:55090644:G:GA	donor_gain	1.0000
X:55091328:TAA:T	acceptor_loss	1.0000
X:55091329:AAG:A	acceptor_gain	1.0000
X:55091329:AAGG:A	acceptor_gain	1.0000
X:55091330:A:AG	acceptor_gain	1.0000
X:55091330:A:AT	acceptor_loss	1.0000
X:55091331:G:A	acceptor_gain	1.0000
X:55091331:G:GC	acceptor_loss	1.0000
X:55091331:G:GG	acceptor_gain	1.0000
X:55091411:G:GT	donor_gain	1.0000
X:55091412:G:T	donor_gain	1.0000
X:55091455:CAG:C	donor_loss	1.0000
X:55091456:AG:A	donor_loss	1.0000
X:55091457:GGTT:G	donor_loss	1.0000
X:55091458:GTTT:G	donor_loss	1.0000
X:55091459:T:G	donor_loss	1.0000
X:55089102:CGG:C	donor_loss	0.9900
X:55089104:G:A	donor_loss	0.9900

AlphaMissense

726 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:55091430:T:C	F98L	0.646
X:55091432:T:A	F98L	0.646
X:55091432:T:G	F98L	0.646

dbSNP variants (sampled 300 via entrez): RS1005641599 (X:55088027 G>T), RS1005695482 (X:55088516 CAG>C), RS1005975021 (X:55089938 A>G,T), RS1006026095 (X:55090364 A>G), RS1006579739 (X:55088974 G>A), RS1006672871 (X:55089230 A>C), RS1006882752 (X:55087340 T>C,G), RS1008298580 (X:55091185 C>A,G,T), RS1011576250 (X:55087183 C>T), RS1012291547 (X:55088149 G>T), RS1012831215 (X:55088487 T>TAA), RS1013492515 (X:55089894 C>A), RS1015775633 (X:55088031 C>T), RS1015788484 (X:55088562 C>T), RS1016533739 (X:55090364 ATCATC>A)

Disease associations

OMIM: gene MIM:300738 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST90002390_292	Mean corpuscular hemoglobin	2.000000e-21
GCST90002392_239	Mean corpuscular volume	1.000000e-16

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

10 total (human), top 10 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation	1
hydroxyhydroquinone	decreases expression	1
zinc chromate	increases abundance, increases expression	1
chromium hexavalent ion	increases abundance, increases expression	1
Decitabine	increases expression	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	decreases expression	1
Silicon Dioxide	increases expression	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.