PAK1IP1

Summary

PAK1IP1 (PAK1 interacting protein 1, HGNC:20882) is a protein-coding gene on chromosome 6p24.2, encoding p21-activated protein kinase-interacting protein 1 (Q9NWT1). Negatively regulates the PAK1 kinase. It is a common-essential gene (DepMap: required in 98.4% of cancer cell lines).

Predicted to enable protein kinase inhibitor activity. Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus.

Source: NCBI Gene 55003 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 63 total
• Cancer dependency (DepMap): dependent in 98.4% of screened cell lines (common-essential)
• MANE Select transcript: NM_017906

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20882
Approved symbol	PAK1IP1
Name	PAK1 interacting protein 1
Location	6p24.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20624, hPIP1, PIP1, bA421M1.5, MAK11, WDR84
Ensembl gene	ENSG00000111845
Ensembl biotype	protein_coding
OMIM	607811
Entrez	55003

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 protein_coding

ENST00000379568, ENST00000896220, ENST00000930921, ENST00000930922, ENST00000930923, ENST00000930924, ENST00000930925, ENST00000930926, ENST00000930927, ENST00000966254

RefSeq mRNA: 1 — MANE Select: NM_017906 NM_017906

CCDS: CCDS34339

Canonical transcript exons

ENST00000379568 — 10 exons

Exon	Start	End
ENSE00000615776	10702369	10702489
ENSE00000684551	10708953	10709076
ENSE00000684554	10707415	10707514
ENSE00000684556	10704747	10704844
ENSE00000684559	10704507	10704652
ENSE00000684562	10703405	10703457
ENSE00000684564	10702565	10702639
ENSE00000848000	10697324	10697486
ENSE00001481611	10709238	10709782
ENSE00001481661	10694972	10695069

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 91.49.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.6153 / max 310.2371, expressed in 1813 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65776	33.1481	1813
65775	0.4672	244

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prostate gland	UBERON:0002367	91.49	gold quality
calcaneal tendon	UBERON:0003701	90.09	gold quality
endometrium	UBERON:0001295	89.96	gold quality
cortical plate	UBERON:0005343	89.26	gold quality
islet of Langerhans	UBERON:0000006	88.52	gold quality
esophagus mucosa	UBERON:0002469	87.83	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.77	gold quality
smooth muscle tissue	UBERON:0001135	87.44	gold quality
gastrocnemius	UBERON:0001388	86.67	gold quality
muscle of leg	UBERON:0001383	86.21	gold quality
monocyte	CL:0000576	86.18	gold quality
leukocyte	CL:0000738	85.84	gold quality
rectum	UBERON:0001052	85.67	gold quality
vermiform appendix	UBERON:0001154	85.55	gold quality
omental fat pad	UBERON:0010414	85.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.31	gold quality
esophagus	UBERON:0001043	85.24	gold quality
mucosa of transverse colon	UBERON:0004991	85.15	gold quality
placenta	UBERON:0001987	85.12	gold quality
pancreas	UBERON:0001264	84.94	gold quality
tibial nerve	UBERON:0001323	84.60	gold quality
left adrenal gland	UBERON:0001234	84.56	gold quality
left uterine tube	UBERON:0001303	84.54	gold quality
adrenal gland	UBERON:0002369	84.47	gold quality
adipose tissue	UBERON:0001013	84.41	gold quality
lymph node	UBERON:0000029	84.34	gold quality
muscle tissue	UBERON:0002385	84.30	gold quality
left adrenal gland cortex	UBERON:0035825	84.27	gold quality
tonsil	UBERON:0002372	84.07	gold quality
corpus callosum	UBERON:0002336	83.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

54 targeting PAK1IP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.4% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. (PMID:23935987)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	pak1ip1	ENSDARG00000044488
mus_musculus	Pak1ip1	ENSMUSG00000038683
rattus_norvegicus	Tmem14c	ENSRNOG00000015437
drosophila_melanogaster	CG12608	FBGN0030630

Paralogs (26): PAFAH1B1 (ENSG00000007168), SNRNP40 (ENSG00000060688), WDR62 (ENSG00000075702), WDR7 (ENSG00000091157), TBL2 (ENSG00000106638), WDR75 (ENSG00000115368), DCAF4 (ENSG00000119599), DAW1 (ENSG00000123977), TEP1 (ENSG00000129566), AHI1 (ENSG00000135541), WDR38 (ENSG00000136918), MAPKBP1 (ENSG00000137802), POC1B (ENSG00000139323), NEDD1 (ENSG00000139350), COP1 (ENSG00000143207), WDR17 (ENSG00000150627), WDR43 (ENSG00000163811), POC1A (ENSG00000164087), WDR88 (ENSG00000166359), WDR81 (ENSG00000167716), DCAF4L2 (ENSG00000176566), DCAF4L1 (ENSG00000182308), WDR27 (ENSG00000184465), NWD1 (ENSG00000188039), WDR5 (ENSG00000196363), WDR5B (ENSG00000196981)

Protein

Protein identifiers

p21-activated protein kinase-interacting protein 1 — Q9NWT1 (reviewed: Q9NWT1)

Alternative names: PAK/PLC-interacting protein 1, PAK1-interacting protein 1, WD repeat-containing protein 84

All UniProt accessions (2): Q9NWT1, A0A0S2Z5C3

UniProt curated annotations — full annotation on UniProt →

Function. Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.

Subunit / interactions. Interacts with PAK1.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.

RefSeq proteins (1): NP_060376* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR051959	PAK1-Kinase_Regulator	Family

Pfam: PF00400

UniProt features (18 total): sequence conflict 7, repeat 6, compositionally biased region 2, chain 1, modified residue 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NWT1-F1	81.27	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 320

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 165 (showing top): GOBP_RIBOSOME_BIOGENESIS, MULLIGHAN_NPM1_SIGNATURE_3_UP, chr6p24, LFA1_Q6, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, MODULE_453, PAX8_B, NKX62_Q2, MODULE_256, GOBP_MATURATION_OF_LSU_RRNA, WTGAAAT_UNKNOWN, HNF4_DR1_Q3, PPAR_DR1_Q2, GARY_CD5_TARGETS_DN, HTF_01

GO Biological Process (7): maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000463), cell population proliferation (GO:0008283), negative regulation of signal transduction (GO:0009968), ribosomal large subunit biogenesis (GO:0042273), roof of mouth development (GO:0060021), regulation of signal transduction by p53 class mediator (GO:1901796), ribosome biogenesis (GO:0042254)

GO Molecular Function (2): protein kinase inhibitor activity (GO:0004860), protein binding (GO:0005515)

GO Cellular Component (2): nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribonucleoprotein complex biogenesis	2
maturation of LSU-rRNA	1
cellular process	1
signal transduction	1
regulation of signal transduction	1
negative regulation of cell communication	1
negative regulation of signaling	1
negative regulation of response to stimulus	1
ribosome biogenesis	1
anatomical structure development	1
signal transduction by p53 class mediator	1
regulation of intracellular signal transduction	1
protein kinase activity	1
kinase inhibitor activity	1
protein kinase regulator activity	1
binding	1
nuclear lumen	1
intracellular membraneless organelle	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1966 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PAK1IP1	RSL24D1	Q9UHA3	841
PAK1IP1	NSA2	O95478	744
PAK1IP1	RPF2	Q9H7B2	740
PAK1IP1	PDCD11	Q14690	718
PAK1IP1	NIP7	Q9Y221	716
PAK1IP1	RRP15	Q9Y3B9	696
PAK1IP1	GNL2	Q13823	682
PAK1IP1	GTPBP4	Q9BZE4	647
PAK1IP1	NOP2	P46087	630
PAK1IP1	CDC40	O60508	617
PAK1IP1	HTATSF1	O43719	605
PAK1IP1	NCK1	P16333	604
PAK1IP1	WDR12	Q9GZL7	601
PAK1IP1	SURF6	O75683	583
PAK1IP1	EBNA1BP2	Q99848	576

IntAct

131 interactions, top by confidence:

A	B	Type	Score
PAK1IP1	MEOX2	psi-mi:“MI:0915”(physical association)	0.720
MEOX2	PAK1IP1	psi-mi:“MI:0915”(physical association)	0.720
KPNA1	TCERG1	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
PLEKHF2	PAK1IP1	psi-mi:“MI:0915”(physical association)	0.560
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF71	DKC1	psi-mi:“MI:0914”(association)	0.530
RPL7A	NVL	psi-mi:“MI:0914”(association)	0.530
Ruvbl1	AAR2	psi-mi:“MI:0914”(association)	0.350
RPL10	RPS6	psi-mi:“MI:0914”(association)	0.350
Srp72		psi-mi:“MI:0914”(association)	0.350
RRP1B	ZNF785	psi-mi:“MI:0914”(association)	0.350
MKI67	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (161): PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Co-fractionation), PAK1IP1 (Co-fractionation), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS), PAK1IP1 (Affinity Capture-MS)

ESM2 similar proteins: A4D1P6, A4IGH4, A7E3S5, A7UVN1, B0W8M5, B2RYI0, B3MRC6, B3NXQ7, B4GXH4, B4JWS7, B4L6T9, B4MA12, B4NER4, B4PYR0, B5DMC9, O74453, O74863, O95163, P57081, Q17CH9, Q2TAF3, Q3TIU4, Q3UMY5, Q4KLQ5, Q5EA99, Q5FVB6, Q5ZKU8, Q5ZLL7, Q68FJ6, Q6C953, Q6DIP5, Q6TEN6, Q6TNS2, Q750U8, Q7TMQ7, Q7TT37, Q7ZVR1, Q7ZY78, Q8BUI3, Q8BX17

Diamond homologs: Q5EA99, Q5ZKU8, Q68FJ6, Q6TNS2, Q9DCE5, Q9NWT1, A0CH87, A0DB19, A0JPH4, A1CF18, A1CQI9, A1CUD6, A1DDL6, A1DP19, A2RRU4, A4R3M4, A4RJV3, A6QM06, A6QX61, A7EKM8, B0XM00, B2B766, B6HP56, B6QC06, B6QC56, B8N9H4, C0NRC6, C4JPW9, C5PFX0, C6HTE8, D1ZEB4, D1ZEM6, D5GBI7, G4MQX3, P83774, P97260, Q00664, Q01369, Q0CCP0, Q0CJD8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 135 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	28	39.0×	3e-36
Viral mRNA Translation	28	39.0×	3e-36
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	28	38.6×	3e-36
Selenocysteine synthesis	28	37.0×	7e-36
Eukaryotic Translation Termination	28	37.0×	7e-36
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	28	36.2×	1e-35
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	28	36.2×	1e-35
Formation of a pool of free 40S subunits	28	34.5×	4e-35

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	29	44.0×	4e-38
translation	29	24.4×	4e-30
ribosomal large subunit biogenesis	6	21.8×	3e-05
rRNA processing	14	16.2×	3e-11
ribosomal small subunit biogenesis	8	14.9×	8e-06
regulation of alternative mRNA splicing, via spliceosome	7	14.0×	5e-05
negative regulation of translation	8	12.8×	2e-05
RNA processing	7	12.6×	7e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1225 predictions. Top by Δscore:

Variant	Effect	Δscore
6:10697484:GTG:G	donor_gain	1.0000
6:10702485:CACAA:C	donor_gain	1.0000
6:10702486:ACAA:A	donor_gain	1.0000
6:10702486:ACAAG:A	donor_loss	1.0000
6:10702487:CAA:C	donor_gain	1.0000
6:10702487:CAAG:C	donor_loss	1.0000
6:10702488:AA:A	donor_gain	1.0000
6:10702489:AG:A	donor_loss	1.0000
6:10702490:G:A	donor_loss	1.0000
6:10702490:G:GG	donor_gain	1.0000
6:10702491:T:A	donor_loss	1.0000
6:10702492:GA:G	donor_loss	1.0000
6:10704499:A:AG	acceptor_gain	1.0000
6:10704505:A:AG	acceptor_gain	1.0000
6:10704506:G:GT	acceptor_gain	1.0000
6:10704506:GAT:G	acceptor_gain	1.0000
6:10704648:TTTCA:T	donor_gain	1.0000
6:10704649:TTCA:T	donor_gain	1.0000
6:10704650:TCA:T	donor_gain	1.0000
6:10704650:TCAG:T	donor_loss	1.0000
6:10704651:CA:C	donor_gain	1.0000
6:10704651:CAG:C	donor_loss	1.0000
6:10704652:AGT:A	donor_loss	1.0000
6:10704653:G:GG	donor_gain	1.0000
6:10704654:T:A	donor_loss	1.0000
6:10704655:AAG:A	donor_loss	1.0000
6:10704744:TAG:T	acceptor_loss	1.0000
6:10704745:A:AG	acceptor_gain	1.0000
6:10704745:A:AT	acceptor_loss	1.0000
6:10704745:AG:A	acceptor_gain	1.0000

AlphaMissense

2610 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:10702413:A:C	S98R	0.999
6:10702415:T:A	S98R	0.999
6:10702415:T:G	S98R	0.999
6:10703409:T:A	W150R	0.999
6:10703409:T:C	W150R	0.999
6:10704524:T:A	W172R	0.999
6:10704524:T:C	W172R	0.999
6:10702609:C:A	A138D	0.998
6:10702612:T:C	L139P	0.998
6:10702614:T:C	S140P	0.998
6:10702618:T:A	V141D	0.998
6:10697414:A:C	S59R	0.997
6:10697416:C:A	S59R	0.997
6:10697416:C:G	S59R	0.997
6:10702443:T:A	W108R	0.997
6:10702443:T:C	W108R	0.997
6:10702615:C:G	S140W	0.997
6:10703436:T:C	F159L	0.997
6:10703438:C:A	F159L	0.997
6:10703438:C:G	F159L	0.997
6:10697411:G:T	G58W	0.996
6:10697412:G:A	G58E	0.996
6:10697420:G:C	D61H	0.996
6:10702584:T:C	S130P	0.996
6:10702620:G:C	G142R	0.996
6:10702621:G:T	G142V	0.996
6:10702626:G:C	D144H	0.996
6:10702627:A:T	D144V	0.996
6:10704526:G:C	W172C	0.996
6:10704526:G:T	W172C	0.996

dbSNP variants (sampled 300 via entrez): RS1000038898 (6:10694166 AG>A), RS1001055212 (6:10704648 T>C), RS1001162607 (6:10698230 A>G), RS1001381326 (6:10707812 A>G), RS1001463349 (6:10695389 A>G), RS1001512278 (6:10698005 A>G), RS1001712315 (6:10693280 C>A,T), RS1002027843 (6:10691882 G>A), RS1002080127 (6:10692237 G>C,T), RS1002153952 (6:10692472 T>C), RS1002219891 (6:10708581 C>T), RS1002241269 (6:10702261 GAA>G,GA,GAAA), RS1002668895 (6:10697614 A>G,T), RS1002783555 (6:10709635 T>C), RS1002960331 (6:10709959 G>C)

Disease associations

OMIM: gene MIM:607811 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

55 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, affects expression, decreases expression	3
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	2
Cyclosporine	increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression, affects cotreatment	2
FR900359	decreases phosphorylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
deoxynivalenol	increases expression	1
trichostatin A	affects expression	1
cobaltous chloride	decreases expression	1
butyraldehyde	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
cylindrospermopsin	increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
abrine	increases expression	1
bisphenol S	affects expression	1
jinfukang	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Caffeine	decreases phosphorylation	1
Calcitriol	increases expression, affects cotreatment	1
Cisplatin	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.