PANCR

Summary

PANCR (PITX2 adjacent non-coding RNA, HGNC:52282) is a long non-coding RNA gene on chromosome 4q25.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52282
Approved symbol	PANCR
Name	PITX2 adjacent non-coding RNA
Location	4q25
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-380D23.2
Ensembl gene	ENSG00000250103
Ensembl biotype	lncRNA
OMIM	617286
Entrez	110231149
RNAcentral	URS0000BC44B6 — lncRNA, 465 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 34 — 34 lncRNA

ENST00000503456, ENST00000503998, ENST00000513690, ENST00000690430, ENST00000791959, ENST00000791960, ENST00000791961, ENST00000791962, ENST00000791963, ENST00000791964, ENST00000792098, ENST00000792099, ENST00000792100, ENST00000792101, ENST00000792102, ENST00000792103, ENST00000792104, ENST00000792105, ENST00000792106, ENST00000792107, ENST00000792108, ENST00000792109, ENST00000792110, ENST00000792111, ENST00000792112, ENST00000792113, ENST00000792114, ENST00000792115, ENST00000792116, ENST00000792117, ENST00000792118, ENST00000792119, ENST00000792120, ENST00000792121

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503456 — 4 exons

Exon	Start	End
ENSE00002032138	110604051	110604273
ENSE00002081165	110606210	110606298
ENSE00004173834	110615307	110615562
ENSE00004173837	110603055	110603432

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 85.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6952 / max 65.1067, expressed in 171 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53630	0.4199	146
53629	0.0991	49
53627	0.0920	61
53628	0.0843	44

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.24	silver quality
pituitary gland	UBERON:0000007	77.06	gold quality
adenohypophysis	UBERON:0002196	72.47	gold quality
placenta	UBERON:0001987	69.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.44	gold quality
small intestine	UBERON:0002108	63.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	62.02	gold quality
skeletal muscle tissue	UBERON:0001134	61.49	gold quality
adult mammalian kidney	UBERON:0000082	61.18	gold quality
calcaneal tendon	UBERON:0003701	61.05	gold quality
bone marrow	UBERON:0002371	60.76	gold quality
kidney	UBERON:0002113	60.21	gold quality
saliva-secreting gland	UBERON:0001044	59.73	gold quality
minor salivary gland	UBERON:0001830	59.70	gold quality
urinary bladder	UBERON:0001255	57.50	gold quality
monocyte	CL:0000576	57.11	gold quality
vermiform appendix	UBERON:0001154	56.42	gold quality
right atrium auricular region	UBERON:0006631	56.23	gold quality
cortex of kidney	UBERON:0001225	56.19	gold quality
muscle of leg	UBERON:0001383	56.11	gold quality
blood	UBERON:0000178	55.99	gold quality
intestine	UBERON:0000160	55.41	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.04	gold quality
liver	UBERON:0002107	55.01	gold quality
gastrocnemius	UBERON:0001388	54.60	gold quality
heart	UBERON:0000948	52.74	gold quality
metanephros cortex	UBERON:0010533	52.14	gold quality
fundus of stomach	UBERON:0001160	51.40	gold quality
prefrontal cortex	UBERON:0000451	51.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• PITX2 and PANCR methylation status were shown to be independent predictors for overall survival in HNSCC patients. Tissue-based methylation testing could therefore potentially be employed to identify patients with a high risk for death who might benefit from a more radical or alternative treatment. (PMID:27716615)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.