PANTR1

Summary

PANTR1 (POU3F3 adjacent non-coding transcript 1, HGNC:49513) is a long non-coding RNA gene on chromosome 2q12.1.

Predicted to act upstream of or within regulation of gene expression.

Source: NCBI Gene 100506421 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49513
Approved symbol	PANTR1
Name	POU3F3 adjacent non-coding transcript 1
Location	2q12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-Brn1a, linc-POU3F3
Ensembl gene	ENSG00000233639
Ensembl biotype	lncRNA
OMIM	618169
Entrez	100506421
RNAcentral	URS000075A634 — lncRNA, 2874 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 97 — 97 lncRNA

ENST00000413121, ENST00000421071, ENST00000424321, ENST00000425879, ENST00000443988, ENST00000447876, ENST00000454729, ENST00000458253, ENST00000653760, ENST00000659645, ENST00000661120, ENST00000664478, ENST00000665955, ENST00000669335, ENST00000684827, ENST00000685537, ENST00000686195, ENST00000686273, ENST00000688250, ENST00000689061, ENST00000691114, ENST00000693148, ENST00000702977, ENST00000702984, ENST00000715830, ENST00000715831, ENST00000733170, ENST00000733171, ENST00000733172, ENST00000733173, ENST00000733174, ENST00000733175, ENST00000733176, ENST00000733177, ENST00000733178, ENST00000733179, ENST00000733180, ENST00000733181, ENST00000733182, ENST00000733183, ENST00000733184, ENST00000733185, ENST00000733186, ENST00000733187, ENST00000733188, ENST00000733189, ENST00000733190, ENST00000733191, ENST00000733192, ENST00000733193, ENST00000733194, ENST00000733195, ENST00000733196, ENST00000733197, ENST00000733198, ENST00000733199, ENST00000733200, ENST00000733201, ENST00000733202, ENST00000733203, ENST00000733204, ENST00000733205, ENST00000733206, ENST00000733207, ENST00000733208, ENST00000733209, ENST00000733210, ENST00000733211, ENST00000733212, ENST00000733213, ENST00000733214, ENST00000733215, ENST00000733216, ENST00000733217, ENST00000733218, ENST00000733219, ENST00000733220, ENST00000733221, ENST00000733222, ENST00000733223, ENST00000733224, ENST00000733225, ENST00000733226, ENST00000733227, ENST00000733228, ENST00000733229, ENST00000733230, ENST00000733231, ENST00000733232, ENST00000733233, ENST00000733234, ENST00000733235, ENST00000733236, ENST00000733237, ENST00000733238, ENST00000733239, ENST00000733240

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413121 — 4 exons

Exon	Start	End
ENSE00001718253	104812433	104812618
ENSE00001739397	104812709	104812737
ENSE00003922982	104807566	104807843
ENSE00003928932	104851312	104851484

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 99.68.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0691 / max 16.1794, expressed in 41 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30009	1.7917	170
30011	0.6588	191
30010	0.1246	49
30001	0.0691	41
30008	0.0644	47
30003	0.0200	8

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	99.68	gold quality
ganglionic eminence	UBERON:0004023	99.59	gold quality
caudate nucleus	UBERON:0001873	92.05	gold quality
anterior cingulate cortex	UBERON:0009835	92.00	gold quality
kidney epithelium	UBERON:0004819	91.80	silver quality
cortical plate	UBERON:0005343	91.69	gold quality
putamen	UBERON:0001874	91.06	gold quality
right frontal lobe	UBERON:0002810	90.97	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.71	gold quality
metanephros cortex	UBERON:0010533	90.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.14	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.99	gold quality
nucleus accumbens	UBERON:0001882	89.53	gold quality
amygdala	UBERON:0001876	89.45	gold quality
neocortex	UBERON:0001950	88.30	gold quality
prefrontal cortex	UBERON:0000451	88.16	gold quality
cerebral cortex	UBERON:0000956	87.82	gold quality
hypothalamus	UBERON:0001898	87.25	gold quality
spinal cord	UBERON:0002240	87.22	gold quality
frontal cortex	UBERON:0001870	87.18	gold quality
substantia nigra	UBERON:0002038	86.75	gold quality
Ammon’s horn	UBERON:0001954	86.71	gold quality
forebrain	UBERON:0001890	86.22	gold quality
adult mammalian kidney	UBERON:0000082	85.55	gold quality
brain	UBERON:0000955	85.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.50	gold quality
cerebellar hemisphere	UBERON:0002245	84.33	gold quality
primary visual cortex	UBERON:0002436	84.29	gold quality
Brodmann (1909) area 46	UBERON:0006483	84.19	gold quality
cerebellar cortex	UBERON:0002129	84.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Our study supports the first evidence that linc-POU3F3 plays an oncogenic role in hepatocellular carcinoma. (PMID:29906746)
• LncRNA POU3F3 overexpression led to down-regulated TGF-beta1 expression, while exogenous TGF-b1 and TGF-b1 inhibitor treatment did not significantly change the expression level of lncRNA POU3F3. Therefore, lncRNA POU3F3 may promote cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-b1 (PMID:30602452)
• Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p. (PMID:32615948)
• LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5. (PMID:34352801)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.