PAPPA-AS1

Summary

PAPPA-AS1 (PAPPA antisense RNA 1, HGNC:35152) is a long non-coding RNA gene on chromosome 9q33.2.

Predicted to be located in endoplasmic reticulum membrane.

Source: NCBI Gene 493913 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35152
Approved symbol	PAPPA-AS1
Name	PAPPA antisense RNA 1
Location	9q33.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PAPPA-AS, DIPAS, TAF4B, TAF2C2, TAFII105, NCRNA00156
Ensembl gene	ENSG00000256040
Ensembl biotype	lncRNA
OMIM	610689
Entrez	493913
RNAcentral	URS000076217C — lncRNA, 2450 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000445861

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000445861 — 1 exons

Exon	Start	End
ENSE00002298754	116398157	116400606

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 88.16.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	88.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.73	silver quality
stromal cell of endometrium	CL:0002255	79.96	gold quality
colonic epithelium	UBERON:0000397	75.66	gold quality
endometrium	UBERON:0001295	74.71	gold quality
bone marrow cell	CL:0002092	72.18	gold quality
smooth muscle tissue	UBERON:0001135	69.11	gold quality
omental fat pad	UBERON:0010414	67.68	gold quality
myometrium	UBERON:0001296	67.13	gold quality
cortex of kidney	UBERON:0001225	66.86	gold quality
lower esophagus mucosa	UBERON:0035834	66.18	gold quality
esophagus mucosa	UBERON:0002469	65.93	gold quality
muscle tissue	UBERON:0002385	65.51	gold quality
endocervix	UBERON:0000458	65.20	gold quality
uterine cervix	UBERON:0000002	65.16	gold quality
kidney	UBERON:0002113	65.14	gold quality
adult mammalian kidney	UBERON:0000082	65.01	gold quality
thoracic aorta	UBERON:0001515	64.53	gold quality
body of uterus	UBERON:0009853	64.52	gold quality
ascending aorta	UBERON:0001496	64.48	gold quality
islet of Langerhans	UBERON:0000006	63.91	gold quality
descending thoracic aorta	UBERON:0002345	63.20	gold quality
left adrenal gland cortex	UBERON:0035825	62.83	gold quality
left adrenal gland	UBERON:0001234	62.73	gold quality
right atrium auricular region	UBERON:0006631	62.03	gold quality
tibial artery	UBERON:0007610	62.00	gold quality
left uterine tube	UBERON:0001303	61.99	gold quality
popliteal artery	UBERON:0002250	61.95	gold quality
adipose tissue	UBERON:0001013	61.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Down-regulated circPAPPA suppresses the proliferation and invasion of trophoblast cells via the miR-384/STAT3 pathway. (PMID:31427481)
• lncRNA PAPPA-AS1 Induces the Development of Hypertrophic Scar by Upregulating TLR4 through Interacting with TAF15. (PMID:34285657)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.