PAPPA-AS2

Summary

PAPPA-AS2 (PAPPA antisense RNA 2, HGNC:35160) is a long non-coding RNA gene on chromosome 9q33.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35160
Approved symbol	PAPPA-AS2
Name	PAPPA antisense RNA 2
Location	9q33.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	AGU1
Ensembl gene	ENSG00000226604
Ensembl biotype	lncRNA
Entrez	103611155
RNAcentral	URS00021231FF — lncRNA, 2511 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000438048

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438048 — 2 exons

Exon	Start	End
ENSE00001708181	116285829	116287588
ENSE00001714141	116288676	116288769

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 84.03.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5771 / max 130.7718, expressed in 84 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102246	0.5711	83
102247	0.0060	2

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.03	gold quality
cortical plate	UBERON:0005343	60.93	gold quality
tonsil	UBERON:0002372	59.98	silver quality
ventricular zone	UBERON:0003053	58.07	silver quality
stromal cell of endometrium	CL:0002255	56.59	gold quality
adenohypophysis	UBERON:0002196	55.21	gold quality
ganglionic eminence	UBERON:0004023	54.66	silver quality
myometrium	UBERON:0001296	53.96	silver quality
monocyte	CL:0000576	53.14	gold quality
cortex of kidney	UBERON:0001225	52.76	gold quality
stomach	UBERON:0000945	52.53	silver quality
placenta	UBERON:0001987	51.36	gold quality
endometrium	UBERON:0001295	51.29	silver quality
kidney	UBERON:0002113	50.99	gold quality
adrenal tissue	UBERON:0018303	50.73	silver quality
metanephros cortex	UBERON:0010533	50.65	gold quality
hindlimb stylopod muscle	UBERON:0004252	49.47	silver quality
esophagus	UBERON:0001043	49.29	silver quality
primary visual cortex	UBERON:0002436	48.93	gold quality
prefrontal cortex	UBERON:0000451	48.57	silver quality
islet of Langerhans	UBERON:0000006	47.91	silver quality
adult mammalian kidney	UBERON:0000082	47.86	gold quality
blood	UBERON:0000178	46.15	silver quality
adrenal gland	UBERON:0002369	45.80	silver quality
cerebellar cortex	UBERON:0002129	45.43	silver quality
gastrocnemius	UBERON:0001388	45.01	silver quality
cerebellar hemisphere	UBERON:0002245	44.71	silver quality
left adrenal gland cortex	UBERON:0035825	44.69	gold quality
body of pancreas	UBERON:0001150	44.66	silver quality
heart left ventricle	UBERON:0002084	44.63	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.96

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.