PARAL1

Summary

PARAL1 (PPARG activating RBM14 associated lncRNA 1, HGNC:53772) is a long non-coding RNA gene on chromosome 20p12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53772
Approved symbol	PARAL1
Name	PPARG activating RBM14 associated lncRNA 1
Location	20p12.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	NR_109
Ensembl gene	ENSG00000243961
Ensembl biotype	lncRNA
Entrez	101929371
RNAcentral	URS000075C373 — lncRNA, 808 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000449270

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000449270 — 2 exons

Exon	Start	End
ENSE00001727795	10006513	10007116
ENSE00001736075	9986088	9986519

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 74.98.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0729 / max 26.5804, expressed in 17 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
183508	0.0729	17

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	74.98	gold quality
omental fat pad	UBERON:0010414	73.02	gold quality
adipose tissue	UBERON:0001013	70.78	gold quality
thoracic mammary gland	UBERON:0005200	69.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.71	gold quality
lung	UBERON:0002048	68.15	gold quality
upper lobe of left lung	UBERON:0008952	66.90	gold quality
right ovary	UBERON:0002118	64.97	gold quality
left coronary artery	UBERON:0001626	62.93	gold quality
ventricular zone	UBERON:0003053	61.47	gold quality
fundus of stomach	UBERON:0001160	56.20	gold quality
blood	UBERON:0000178	55.55	gold quality
prefrontal cortex	UBERON:0000451	54.84	gold quality
multicellular organism	UBERON:0000468	54.77	gold quality
myometrium	UBERON:0001296	54.05	gold quality
urinary bladder	UBERON:0001255	53.61	gold quality
skin of abdomen	UBERON:0001416	53.59	gold quality
heart	UBERON:0000948	53.46	gold quality
right atrium auricular region	UBERON:0006631	52.39	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.29	gold quality
vagina	UBERON:0000996	51.64	gold quality
lymph node	UBERON:0000029	51.51	silver quality
muscle layer of sigmoid colon	UBERON:0035805	51.23	gold quality
Brodmann (1909) area 9	UBERON:0013540	51.07	gold quality
cerebellum	UBERON:0002037	50.95	gold quality
cerebellar cortex	UBERON:0002129	50.94	gold quality
cerebellar hemisphere	UBERON:0002245	50.90	gold quality
pancreas	UBERON:0001264	50.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	50.80	gold quality
body of pancreas	UBERON:0001150	50.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.01

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lincRNA Paral1 is an obesity-sensitive regulator of adipocyte differentiation and function. Paral1 expression is restricted to adipocytes and decreased in humans with increasing body mass index. A decreased expression was also observed in diet-induced or genetic mouse models of obesity and this down-regulation was mimicked in vitro by TNF treatment. In conclusion, we have identified a novel component (PMID:29075020)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.