PARD6G-AS1

Summary

PARD6G-AS1 (PARD6G antisense RNA 1, HGNC:44109) is a long non-coding RNA gene on chromosome 18q23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44109
Approved symbol	PARD6G-AS1
Name	PARD6G antisense RNA 1
Location	18q23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267270
Ensembl biotype	lncRNA
Entrez	100130522
RNAcentral	URS000075E54F — lncRNA, 3352 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000585422, ENST00000586421, ENST00000587254, ENST00000588226, ENST00000589574, ENST00000662611, ENST00000690381, ENST00000691090, ENST00000720747, ENST00000720748

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585422 — 2 exons

Exon	Start	End
ENSE00002793217	80168819	80169137
ENSE00002812680	80148049	80148254

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 83.03.

FANTOM5 (CAGE): breadth broad, TPM avg 8.6844 / max 3952.9542, expressed in 648 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170929	8.0490	453
170928	0.6353	306

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	83.03	gold quality
ventricular zone	UBERON:0003053	79.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.51	gold quality
cortical plate	UBERON:0005343	77.02	gold quality
adenohypophysis	UBERON:0002196	76.15	gold quality
pituitary gland	UBERON:0000007	75.43	gold quality
ganglionic eminence	UBERON:0004023	74.42	gold quality
skin of abdomen	UBERON:0001416	74.17	gold quality
right lobe of liver	UBERON:0001114	73.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.83	gold quality
sural nerve	UBERON:0015488	73.28	gold quality
skin of leg	UBERON:0001511	73.20	gold quality
left testis	UBERON:0004533	73.19	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.03	gold quality
anterior cingulate cortex	UBERON:0009835	72.40	gold quality
hypothalamus	UBERON:0001898	72.19	gold quality
left ovary	UBERON:0002119	72.11	gold quality
right testis	UBERON:0004534	71.87	gold quality
right ovary	UBERON:0002118	71.38	gold quality
testis	UBERON:0000473	71.04	gold quality
body of pancreas	UBERON:0001150	70.58	gold quality
stromal cell of endometrium	CL:0002255	70.57	gold quality
lower esophagus mucosa	UBERON:0035834	70.13	gold quality
zone of skin	UBERON:0000014	69.88	gold quality
nucleus accumbens	UBERON:0001882	69.77	gold quality
right frontal lobe	UBERON:0002810	69.49	gold quality
left lobe of thyroid gland	UBERON:0001120	69.42	gold quality
amygdala	UBERON:0001876	69.41	gold quality
body of uterus	UBERON:0009853	69.29	gold quality
ectocervix	UBERON:0012249	69.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Maternal 5mCpG imprints at the PARD6G-AS1 gametic (primary) differentially methylated region (iDMR) are decoupled from parent-of-origin expression effects in multiple human tissues. Despite the constitutive methylation asymmetry observed between the parental alleles at the iDMR, PARD6G-AS1 was expressed biallelically in six tissues: brain amygdala, brain putamen, heart atrial appendage, pituitary, testis, and thyroid. (PMID:29545821)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.