PARPBP

Summary

PARPBP (PARP1 binding protein, HGNC:26074) is a protein-coding gene on chromosome 12q23.2, encoding PCNA-interacting partner (Q9NWS1). Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability.

Predicted to enable DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in chromatin and nucleoplasm.

Source: NCBI Gene 55010 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 105 total
• MANE Select transcript: NM_017915

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26074
Approved symbol	PARPBP
Name	PARP1 binding protein
Location	12q23.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20641, PARI
Ensembl gene	ENSG00000185480
Ensembl biotype	protein_coding
OMIM	613687
Entrez	55010

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 19 protein_coding, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000327680, ENST00000392909, ENST00000392911, ENST00000392914, ENST00000412715, ENST00000417507, ENST00000457614, ENST00000535811, ENST00000537257, ENST00000541394, ENST00000541668, ENST00000543784, ENST00000852220, ENST00000852221, ENST00000852222, ENST00000852223, ENST00000929768, ENST00000929769, ENST00000929770, ENST00000929771, ENST00000929772, ENST00000929773, ENST00000967998, ENST00000967999

RefSeq mRNA: 67 — MANE Select: NM_017915 NM_001319988, NM_001319993, NM_001319994, NM_001319996, NM_001382721, NM_001382722, NM_001382723, NM_001382724, NM_001382725, NM_001382726, NM_001382728, NM_001382729, NM_001382731, NM_001382732, NM_001382735, NM_001400853, NM_001400854, NM_001400855, NM_001400856, NM_001400857, NM_001400858, NM_001400859, NM_001400860, NM_001400861, NM_001400862, NM_001400863, NM_001400864, NM_001400865, NM_001400866, NM_001400867, NM_001400868, NM_001400869, NM_001400870, NM_001400871, NM_001400872, NM_001400873, NM_001400874, NM_001400875, NM_001400876, NM_001400877, NM_001400878, NM_001400879, NM_001400880, NM_001400881, NM_001400883, NM_001400885, NM_001400886, NM_001400887, NM_001400888, NM_001400889, NM_001400890, NM_001400891, NM_001400892, NM_001400893, NM_001400894, NM_001400895, NM_001400902, NM_001400903, NM_001400905, NM_001400906, NM_001400907, NM_001400925, NM_001400926, NM_001400927, NM_001400928, NM_001400929, NM_017915

CCDS: CCDS81728, CCDS81729, CCDS81730, CCDS9090, CCDS91743

Canonical transcript exons

ENST00000327680 — 11 exons

Exon	Start	End
ENSE00001314302	102164438	102164608
ENSE00003490031	102123886	102124041
ENSE00003495299	102165729	102165883
ENSE00003502613	102182549	102182627
ENSE00003529925	102175483	102175666
ENSE00003571928	102195951	102197520
ENSE00003591981	102195312	102195447
ENSE00003595314	102153869	102153976
ENSE00003654471	102178592	102178770
ENSE00003747564	102148230	102148463
ENSE00003908586	102120183	102120286

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 88.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.7666 / max 204.9543, expressed in 1541 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127678	6.2298	1393
127679	1.9197	853
127680	1.5825	737
127681	0.0347	7

Top tissues by expression

267 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.27	gold quality
ventricular zone	UBERON:0003053	87.50	gold quality
ganglionic eminence	UBERON:0004023	82.66	gold quality
secondary oocyte	CL:0000655	82.39	gold quality
embryo	UBERON:0000922	81.29	gold quality
lower esophagus mucosa	UBERON:0035834	81.14	gold quality
tongue squamous epithelium	UBERON:0006919	79.05	silver quality
bone marrow cell	CL:0002092	76.68	gold quality
rectum	UBERON:0001052	76.45	gold quality
stromal cell of endometrium	CL:0002255	76.41	gold quality
adrenal tissue	UBERON:0018303	76.27	gold quality
mucosa of transverse colon	UBERON:0004991	76.24	gold quality
esophagus mucosa	UBERON:0002469	75.82	gold quality
bone marrow	UBERON:0002371	75.35	gold quality
endometrium	UBERON:0001295	73.61	gold quality
epithelium of nasopharynx	UBERON:0001951	72.43	gold quality
vermiform appendix	UBERON:0001154	70.66	gold quality
hair follicle	UBERON:0002073	70.28	gold quality
lymph node	UBERON:0000029	70.01	gold quality
monocyte	CL:0000576	69.97	gold quality
mononuclear cell	CL:0000842	69.78	gold quality
leukocyte	CL:0000738	69.69	gold quality
hypothalamus	UBERON:0001898	68.88	gold quality
smooth muscle tissue	UBERON:0001135	68.79	gold quality
calcaneal tendon	UBERON:0003701	68.45	gold quality
esophagus	UBERON:0001043	68.13	gold quality
testis	UBERON:0000473	67.74	gold quality
colonic epithelium	UBERON:0000397	67.69	gold quality
right testis	UBERON:0004534	67.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.76

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

74 targeting PARPBP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4682	100.00	68.89	1258
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-548A-3P	99.76	70.58	3524

Literature-anchored findings (GeneRIF, showing 11)

• Demonstrated that C12orf48 protein could directly interact with Poly(ADP-ribose) Polymerase-1 (PARP-1). Knockdown of C12orf48 by siRNA in PDAC cells significantly suppressed their growth. (PMID:20931645)
• PARI suppresses inappropriate recombination events at mammalian replication forks. (PMID:22153967)
• Knockdown of C12orf48 by siRNA in HeLa cells significantly suppressed their growth (PMID:23039964)
• PARI overexpression promotes genomic instability and pancreatic tumorigenesis. (PMID:23436799)
• PARI inhibits homologous recombination in vivo, and its knockdown suppresses the UV sensitivity of RAD18-depleted cells (PMID:26792895)
• PARI is a latent modulator of stalled fork processing, which is required for stable genome inheritance under both endogenous and exogenous replication stress (PMID:28894029)
• PARI plays potential oncogenic roles and functions as a transcriptional target and effector of FOXM1 in gastric cancer development (PMID:29805304)
• PARP1-binding protein was significantly upregulated in Hepatocellular Carcinoma tissues compared with normal liver. High PARPBP expression was associated with elevated serum AFP level, vascular invasion, poor tumor differentiation, and advanced TNM stage. (PMID:30949905)
• show that PARI expression negatively correlates with expression of differentiation markers in clinical myeloid leukemia samples, suggesting that targeting PARI may restore differentiation ability of leukemia cells and antagonize their proliferation (PMID:30967629)
• PARPBP expression is enhanced in lung adenocarcinoma tissues and is a potential factor in the progression of lung adenocarcinoma. (PMID:31611199)
• SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP. (PMID:36056690)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	parpbp	ENSDARG00000029944
mus_musculus	Parpbp	ENSMUSG00000035365
rattus_norvegicus	Parpbp	ENSRNOG00000004682

Protein

Protein identifiers

PCNA-interacting partner — Q9NWS1 (reviewed: Q9NWS1)

Alternative names: PARP-1 binding protein, PARP1-binding protein

All UniProt accessions (7): Q9NWS1, A0A0C4DG30, B4DT40, B4DZ31, G8JLI2, H0Y6B3, J3KQY3

UniProt curated annotations — full annotation on UniProt →

Function. Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

Subunit / interactions. Interacts with RAD51 and PCNA. Interacts with PARP1. Interacts with TASOR.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Restricted to testis. Overexpressed in multiple cancer cells.

Domain organisation. Although it shares some sequence similarity with SRS2 yeast helicase, does not contain a functional ATPase domain suggesting it has no helicase activity.

Similarity. Belongs to the PARI family.

Isoforms (7)

UniProt ID	Names	Canonical?
Q9NWS1-1	1	yes
Q9NWS1-2	2
Q9NWS1-3	3
Q9NWS1-4	4
Q9NWS1-5	5
Q9NWS1-6	6
Q9NWS1-7	7

RefSeq proteins (66): NP_001306917, NP_001306922, NP_001306923, NP_001306925, NP_001369650, NP_001369651, NP_001369652, NP_001369653, NP_001369654, NP_001369655, NP_001369657, NP_001369658, NP_001369660, NP_001369661, NP_001369664, NP_001387782, NP_001387783, NP_001387784, NP_001387785, NP_001387786, NP_001387787, NP_001387788, NP_001387789, NP_001387790, NP_001387791, NP_001387792, NP_001387793, NP_001387794, NP_001387795, NP_001387796, NP_001387797, NP_001387798, NP_001387799, NP_001387800, NP_001387801, NP_001387802, NP_001387803, NP_001387804, NP_001387805, NP_001387806, NP_001387807, NP_001387808, NP_001387809, NP_001387810, NP_001387812, NP_001387814, NP_001387815, NP_001387816, NP_001387817, NP_001387818, NP_001387819, NP_001387820, NP_001387821, NP_001387822, NP_001387823, NP_001387824, NP_001387831, NP_001387832, NP_001387835, NP_001387836, NP_001387854, NP_001387855, NP_001387856, NP_001387857, NP_001387858, NP_060385* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR038932	PARPBP	Family

UniProt features (21 total): splice variant 11, sequence conflict 6, chain 1, region of interest 1, sequence variant 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NWS1-F1	70.70	0.37

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 189 (showing top): GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR, GOBP_REGULATION_OF_DNA_RECOMBINATION, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_NEGATIVE_REGULATION_OF_DNA_REPAIR, GOBP_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION, GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION, GOBP_REGULATION_OF_DNA_REPAIR, SHEPARD_BMYB_MORPHOLINO_DN, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_DNA_DAMAGE_RESPONSE, FUJII_YBX1_TARGETS_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS, FISCHER_DREAM_TARGETS, GOBP_RECOMBINATIONAL_REPAIR

GO Biological Process (3): DNA repair (GO:0006281), negative regulation of double-strand break repair via homologous recombination (GO:2000042), DNA damage response (GO:0006974)

GO Molecular Function (2): DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (4): chromatin (GO:0000785), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
DNA metabolic process	1
DNA damage response	1
double-strand break repair via homologous recombination	1
regulation of double-strand break repair via homologous recombination	1
negative regulation of DNA recombination	1
negative regulation of double-strand break repair	1
cellular response to stress	1
nucleic acid binding	1
binding	1
chromosome	1
nuclear lumen	1
intracellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

3020 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PARPBP	PMCH	P20382	871
PARPBP	PARP1	P09874	802
PARPBP	FIRRM	Q9NSG2	536
PARPBP	H1-0	P07305	520
PARPBP	HSP90AB1	P08238	500
PARPBP	HSP90AA1	P07900	457
PARPBP	WASHC3	Q9Y3C0	449
PARPBP	RAD54L	Q92698	430
PARPBP	NUP37	Q8NFH4	427
PARPBP	CENPI	Q92674	398
PARPBP	RAD51AP1	Q96B01	394
PARPBP	NCAPH	Q15003	378
PARPBP	NPTX1	Q15818	374
PARPBP	CHODL	Q9H9P2	373
PARPBP	HGH1	P0CB43	371

IntAct

5 interactions, top by confidence:

A	B	Type	Score
PARPBP	H1-2	psi-mi:“MI:0915”(physical association)	0.400
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
PARPBP	RPSA2	psi-mi:“MI:0914”(association)	0.350

BioGRID (17): PCNA (Reconstituted Complex), PCNA (Affinity Capture-Western), PARPBP (Reconstituted Complex), RAD51 (Reconstituted Complex), PARPBP (Reconstituted Complex), RAD51 (Biochemical Activity), PARPBP (Two-hybrid), PARPBP (Synthetic Lethality), PARPBP (Proximity Label-MS), PARPBP (Affinity Capture-MS), APOO (Affinity Capture-MS), RPSAP58 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PARPBP (Affinity Capture-MS), PARPBP (Proximity Label-MS)

ESM2 similar proteins: F5H982, O36361, O36373, O36381, O36417, O36419, O36420, O42654, O74387, O75818, P09284, P0C6Z9, P0CAE8, P0CAE9, P0DTP3, P0DTP4, P24437, P26003, P29882, P38299, P40385, P52348, P52359, P52363, P52364, P52376, P52441, P52465, P52534, P92529, Q01021, Q01032, Q01041, Q01500, Q12366, Q18LE3, Q28EM3, Q567C3, Q5RA78, Q5ZKL9

Diamond homologs: F1MF21, Q1RMA6, Q28EM3, Q32N66, Q5ZKL9, Q6IRT3, Q9EQ10, Q9NWS1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

105 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	80
Likely benign	5
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2426 predictions. Top by Δscore:

Variant	Effect	Δscore
12:102120284:CACGT:C	donor_loss	1.0000
12:102120286:CG:C	donor_loss	1.0000
12:102120287:G:GG	donor_gain	1.0000
12:102120288:TAA:T	donor_loss	1.0000
12:102123878:A:AG	acceptor_gain	1.0000
12:102123879:C:G	acceptor_gain	1.0000
12:102123881:TTAA:T	acceptor_loss	1.0000
12:102123882:TAAG:T	acceptor_loss	1.0000
12:102123883:A:AG	acceptor_gain	1.0000
12:102123884:A:C	acceptor_loss	1.0000
12:102123884:A:G	acceptor_gain	1.0000
12:102123885:G:A	acceptor_loss	1.0000
12:102123885:G:GG	acceptor_gain	1.0000
12:102123885:GATA:G	acceptor_gain	1.0000
12:102124040:AG:A	donor_loss	1.0000
12:102124041:GGT:G	donor_loss	1.0000
12:102124042:G:GC	donor_loss	1.0000
12:102148344:G:GT	donor_gain	1.0000
12:102148352:G:GT	donor_gain	1.0000
12:102148376:GAACA:G	donor_gain	1.0000
12:102148380:A:AG	donor_gain	1.0000
12:102148381:G:GG	donor_gain	1.0000
12:102148384:A:AG	donor_gain	1.0000
12:102178590:A:AG	acceptor_gain	1.0000
12:102178591:G:GG	acceptor_gain	1.0000
12:102195944:A:AG	acceptor_gain	1.0000
12:102195945:T:G	acceptor_gain	1.0000
12:102195949:A:AG	acceptor_gain	1.0000
12:102195949:AGAG:A	acceptor_gain	1.0000
12:102195950:G:GG	acceptor_gain	1.0000

AlphaMissense

3844 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:102148242:T:C	F56L	0.989
12:102148244:T:A	F56L	0.989
12:102148244:T:G	F56L	0.989
12:102195339:T:C	F431L	0.987
12:102195341:T:A	F431L	0.987
12:102195341:T:G	F431L	0.987
12:102124024:G:C	A46P	0.985
12:102164558:T:C	F206L	0.983
12:102164560:C:A	F206L	0.983
12:102164560:C:G	F206L	0.983
12:102124016:T:C	L43P	0.981
12:102123938:G:C	R17P	0.979
12:102148275:T:A	W67R	0.978
12:102148275:T:C	W67R	0.978
12:102165741:T:C	F227L	0.976
12:102165743:T:A	F227L	0.976
12:102165743:T:G	F227L	0.976
12:102164491:T:A	N183K	0.974
12:102164491:T:G	N183K	0.974
12:102164572:A:C	K210N	0.973
12:102164572:A:T	K210N	0.973
12:102164579:G:C	A213P	0.973
12:102196277:T:C	F576L	0.970
12:102196279:T:A	F576L	0.970
12:102196279:T:G	F576L	0.970
12:102164559:T:C	F206S	0.969
12:102164568:T:C	L209S	0.968
12:102165733:C:A	A224D	0.968
12:102165820:T:C	L253S	0.967
12:102153876:T:C	L132P	0.966

dbSNP variants (sampled 300 via entrez): RS1000003553 (12:102144365 G>A), RS1000033222 (12:102185716 T>C), RS1000056660 (12:102189414 C>T), RS1000169838 (12:102130211 C>T), RS1000226041 (12:102172526 T>C), RS1000254806 (12:102195858 C>A,T), RS1000257514 (12:102139172 G>GT), RS1000264422 (12:102122230 T>C), RS1000390572 (12:102192376 C>T), RS1000410149 (12:102165594 G>A), RS1000439664 (12:102144700 C>G), RS1000461623 (12:102179564 C>T), RS1000521475 (12:102181853 T>C), RS1000555509 (12:102176605 T>C), RS1000564923 (12:102173953 T>C)

Disease associations

OMIM: gene MIM:613687 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST000522_7	Height	8.000000e-06
GCST004863_37	Mosquito bite size	1.000000e-06
GCST008839_173	Height	3.000000e-97
GCST010002_221	Refractive error	3.000000e-10
GCST010703_2	Brain morphology (MOSTest)	3.000000e-37
GCST012228_552	Waist-hip index	2.000000e-08
GCST012230_46	Waist-to-hip ratio adjusted for BMI	7.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008378	mosquito bite reaction size measurement
EFO:0004346	neuroimaging measurement
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs11111201	PARPBP, PMCH		0.00	0

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
Cyclosporine	decreases expression	3
bisphenol A	decreases expression	2
Valproic Acid	decreases expression	2
aristolochic acid I	decreases expression	1
afuresertib	decreases expression	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	increases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
diallyl trisulfide	decreases expression	1
2-palmitoylglycerol	increases expression	1
bisphenol S	decreases expression, affects cotreatment	1
incobotulinumtoxinA	decreases expression	1
Dasatinib	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Azathioprine	decreases expression	1
Benzo(a)pyrene	decreases expression	1
Calcitriol	decreases expression, affects cotreatment	1
Coumestrol	affects cotreatment, increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Folic Acid	decreases expression, affects cotreatment	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	affects expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TC26	HAP1 PARPBP (-) 1	Cancer cell line	Male
CVCL_TC27	HAP1 PARPBP (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.