PARTICL

Summary

PARTICL (promoter of MAT2A antisense radiation-induced circulating long non-coding RNA, HGNC:50886) is a long non-coding RNA gene on chromosome 2p11.2.

Enables dsDNA-RNA triple helix-forming chromatin adaptor activity and mRNA binding activity. Involved in cellular response to ionizing radiation and regulatory ncRNA-mediated heterochromatin formation. Is active in cytosol and nucleus.

Source: NCBI Gene 100630918 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50886
Approved symbol	PARTICL
Name	promoter of MAT2A antisense radiation-induced circulating long non-coding RNA
Location	2p11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PARTICLE
Ensembl gene	ENSG00000286532
Ensembl biotype	lncRNA
OMIM	616350
Entrez	100630918
RNAcentral	URS000075ADFD — lncRNA, 1432 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000667933, ENST00000737206, ENST00000737207

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000667933 — 1 exons

Exon	Start	End
ENSE00004071220	85537461	85539110

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 88.12.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2260 / max 54.2742, expressed in 618 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29415	1.2260	618

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.12	gold quality
kidney epithelium	UBERON:0004819	85.51	gold quality
left testis	UBERON:0004533	82.01	gold quality
right testis	UBERON:0004534	81.94	gold quality
upper arm skin	UBERON:0004263	81.74	gold quality
testis	UBERON:0000473	80.12	gold quality
middle temporal gyrus	UBERON:0002771	79.84	gold quality
popliteal artery	UBERON:0002250	79.23	gold quality
tibial artery	UBERON:0007610	79.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.19	gold quality
adenohypophysis	UBERON:0002196	78.09	gold quality
cerebellar hemisphere	UBERON:0002245	77.95	gold quality
cerebellar cortex	UBERON:0002129	77.87	gold quality
right hemisphere of cerebellum	UBERON:0014890	77.85	gold quality
pituitary gland	UBERON:0000007	77.72	gold quality
aorta	UBERON:0000947	77.65	gold quality
cortical plate	UBERON:0005343	77.57	gold quality
cerebellum	UBERON:0002037	77.54	gold quality
prefrontal cortex	UBERON:0000451	77.48	gold quality
nasal cavity epithelium	UBERON:0005384	77.31	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	77.21	gold quality
secondary oocyte	CL:0000655	76.51	gold quality
muscle of leg	UBERON:0001383	76.18	gold quality
gastrocnemius	UBERON:0001388	76.17	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.94	gold quality
ascending aorta	UBERON:0001496	75.74	gold quality
tibial nerve	UBERON:0001323	75.72	gold quality
left coronary artery	UBERON:0001626	75.69	gold quality
thoracic aorta	UBERON:0001515	75.66	gold quality
lower esophagus muscularis layer	UBERON:0035833	75.63	gold quality

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation. (PMID:25900080)
• The evidence for a second functional site of PARTICLE triplex formation at WWOX suggests that PARTICLE may form triplex-mediated interactions at multiple positions in the human genome including remote loci. These findings provide a mechanistic explanation for the ability of lncRNAs to regulate the expression of numerous genes distributed across the genome. (PMID:28769061)
• The correlation of PARTICLE triplex formation sites within tumor suppressor genes and their abundance throughout the genome at cancer-related hotspots offers an insight into potential avenues worth exploring in future therapeutic endeavors (PMID:31058319)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.