PARVG

Summary

PARVG (parvin gamma, HGNC:14654) is a protein-coding gene on chromosome 22q13.31, encoding Gamma-parvin (Q9HBI0). Plays a role with ILK in promoting the cell adhesion and spreading of leukocytes.

Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.

Source: NCBI Gene 64098 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 70 total
• Druggable target: yes
• MANE Select transcript: NM_022141

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14654
Approved symbol	PARVG
Name	parvin gamma
Location	22q13.31
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000138964
Ensembl biotype	protein_coding
OMIM	608122
Entrez	64098

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 29 protein_coding, 3 retained_intron, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000356909, ENST00000416291, ENST00000417767, ENST00000422871, ENST00000444313, ENST00000453888, ENST00000466375, ENST00000468564, ENST00000471836, ENST00000472551, ENST00000475485, ENST00000877232, ENST00000877233, ENST00000877234, ENST00000877235, ENST00000877236, ENST00000877237, ENST00000877238, ENST00000877239, ENST00000877240, ENST00000877241, ENST00000877242, ENST00000877243, ENST00000877244, ENST00000964876, ENST00000964877, ENST00000964878, ENST00000964879, ENST00000964880, ENST00000964881, ENST00000964882, ENST00000964883, ENST00000964884, ENST00000964885, ENST00000964886

RefSeq mRNA: 2 — MANE Select: NM_022141 NM_001137605, NM_022141

CCDS: CCDS14057

Canonical transcript exons

ENST00000444313 — 14 exons

Exon	Start	End
ENSE00000936027	44187776	44187878
ENSE00001293697	44192049	44192104
ENSE00001304819	44196155	44196213
ENSE00001314749	44193801	44193823
ENSE00001378160	44181742	44181917
ENSE00001721467	44180925	44181185
ENSE00001817279	44206317	44208469
ENSE00003494586	44190551	44190666
ENSE00003524318	44205757	44205829
ENSE00003537346	44198621	44198722
ENSE00003555625	44189114	44189254
ENSE00003690222	44196347	44196415
ENSE00003701194	44185808	44185872
ENSE00003799424	44183318	44183408

Expression profiles

Bgee: expression breadth ubiquitous, 200 present calls, max score 98.96.

FANTOM5 (CAGE): breadth broad, TPM avg 15.0142 / max 1323.8581, expressed in 550 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192668	6.3576	462
192665	3.8054	437
192666	1.2683	319
192659	0.7009	157
192670	0.5588	221
192662	0.5168	181
192664	0.4477	191
192660	0.3206	103
192667	0.2745	119
192658	0.2314	92

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	98.96	gold quality
monocyte	CL:0000576	98.34	gold quality
leukocyte	CL:0000738	98.26	gold quality
spleen	UBERON:0002106	97.39	gold quality
blood	UBERON:0000178	96.92	gold quality
vermiform appendix	UBERON:0001154	96.82	gold quality
lymph node	UBERON:0000029	95.46	gold quality
bone marrow	UBERON:0002371	93.55	gold quality
bone marrow cell	CL:0002092	93.46	gold quality
upper lobe of left lung	UBERON:0008952	91.92	gold quality
right lung	UBERON:0002167	91.28	gold quality
upper lobe of lung	UBERON:0008948	91.11	gold quality
caecum	UBERON:0001153	90.14	gold quality
oocyte	CL:0000023	89.75	gold quality
ileal mucosa	UBERON:0000331	89.43	gold quality
small intestine Peyer’s patch	UBERON:0003454	89.11	gold quality
gall bladder	UBERON:0002110	88.96	gold quality
trabecular bone tissue	UBERON:0002483	88.56	gold quality
thymus	UBERON:0002370	87.67	gold quality
small intestine	UBERON:0002108	87.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.49	gold quality
superficial temporal artery	UBERON:0001614	85.97	gold quality
right coronary artery	UBERON:0001625	85.64	gold quality
tonsil	UBERON:0002372	85.31	gold quality
lung	UBERON:0002048	85.19	gold quality
left ventricle myocardium	UBERON:0006566	84.85	gold quality
omental fat pad	UBERON:0010414	84.85	gold quality
peritoneum	UBERON:0002358	84.79	gold quality
cardiac muscle of right atrium	UBERON:0003379	84.62	gold quality
spinal cord	UBERON:0002240	84.47	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	21.19
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

76 targeting PARVG, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-378G	99.71	64.90	1106
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-6887-3P	99.66	67.83	1778

Literature-anchored findings (GeneRIF, showing 4)

• Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization. (PMID:11722847)
• INI1hSNF5 and PARVG do not seem to be the tumor suppressor genes involved in oligodendroglioma development and progression (PMID:15993274)
• integrin-linked kinase-gamma-parvin complex is critically involved in the initial integrin signaling for leukocyte migration (PMID:16517730)
• Suggest role for PARVG gene polymorphisms in operational renal allograft tolerance. (PMID:23146538)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	parvg	ENSDARG00000067711
mus_musculus	Parvg	ENSMUSG00000022439
rattus_norvegicus	Parvg	ENSRNOG00000052064
drosophila_melanogaster	parvin	FBGN0052528
caenorhabditis_elegans		WBGENE00003932

Paralogs (2): PARVB (ENSG00000188677), PARVA (ENSG00000197702)

Protein

Protein identifiers

Gamma-parvin — Q9HBI0 (reviewed: Q9HBI0)

All UniProt accessions (4): B0QYM9, B0QYN0, Q9HBI0, U3KQ67

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role with ILK in promoting the cell adhesion and spreading of leukocytes.

Subunit / interactions. Interacts with ILK; the interaction promotes the establishment of cell polarity required for leukocyte migration. Interacts with ARHGEF6; the guanine nucleotide exchange factor activity of ARHGEF6 is essential for the PARVG-induced enhancement of cell spreading.

Subcellular location. Cell junction. Focal adhesion. Cell membrane. Cytoplasm. Cytoskeleton.

Tissue specificity. Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues.

Similarity. Belongs to the parvin family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9HBI0-1	1	yes
Q9HBI0-2	2
Q9HBI0-3	3
Q9HBI0-4	4
Q9HBI0-5	5

RefSeq proteins (2): NP_001131077, NP_071424* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001715	CH_dom	Domain
IPR028433	Parvin	Family
IPR036872	CH_dom_sf	Homologous_superfamily

Pfam: PF00307

UniProt features (13 total): splice variant 7, domain 2, chain 1, sequence conflict 1, region of interest 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HBI0-F1	81.77	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 135 (showing top): GOBP_REGULATION_OF_CELL_MORPHOGENESIS, GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY, GOBP_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING, GOMF_ACTIN_BINDING, GOBP_CELL_PROJECTION_ORGANIZATION, GOBP_CELL_SUBSTRATE_ADHESION, GOBP_CELL_MATRIX_ADHESION, GOBP_REGULATION_OF_CELL_SHAPE, chr22q13, GOCC_ANCHORING_JUNCTION, GOMF_CYTOSKELETAL_PROTEIN_BINDING, MIKKELSEN_ES_ICP_WITH_H3K27ME3, NRL_DN.V1_DN, CHAF1B_TARGET_GENES, CIITA_TARGET_GENES

GO Biological Process (6): cell-matrix adhesion (GO:0007160), cell projection assembly (GO:0030031), actin cytoskeleton organization (GO:0030036), substrate adhesion-dependent cell spreading (GO:0034446), establishment or maintenance of cell polarity regulating cell shape (GO:0071963), cell adhesion (GO:0007155)

GO Molecular Function (2): actin binding (GO:0003779), protein binding (GO:0005515)

GO Cellular Component (7): cytoplasm (GO:0005737), cytoskeleton (GO:0005856), plasma membrane (GO:0005886), focal adhesion (GO:0005925), actin cytoskeleton (GO:0015629), membrane (GO:0016020), anchoring junction (GO:0070161)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell-substrate adhesion	2
cellular anatomical structure	2
cellular component assembly	1
cell projection organization	1
cytoskeleton organization	1
actin filament-based process	1
establishment or maintenance of cell polarity	1
regulation of cell shape	1
cellular process	1
cytoskeletal protein binding	1
binding	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
membrane	1
cell periphery	1
cell-substrate junction	1
cytoskeleton	1
cell junction	1

Protein interactions and networks

STRING

1466 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PARVG	LIMS1	P48059	997
PARVG	ILK	P57043	997
PARVG	PXN	P49023	935
PARVG	RSU1	Q15404	866
PARVG	TLN2	Q9Y4G6	864
PARVG	TLN1	Q9Y490	855
PARVG	LIMS2	Q7Z4I7	750
PARVG	VCL	P18206	732
PARVG	ARHGEF6	Q15052	730
PARVG	NCK2	O43639	657
PARVG	ZYX	Q15942	584
PARVG	VASP	P50552	549
PARVG	TGFB1I1	O43294	539
PARVG	PTK2	Q05397	533
PARVG	FERMT2	Q96AC1	507

IntAct

139 interactions, top by confidence:

A	B	Type	Score
ILK	PARVG	psi-mi:“MI:0915”(physical association)	0.900
PARVG	ILK	psi-mi:“MI:0915”(physical association)	0.900
STRN3	STRN	psi-mi:“MI:2364”(proximity)	0.880
USHBP1	PARVG	psi-mi:“MI:0915”(physical association)	0.720
PARVG	USHBP1	psi-mi:“MI:0915”(physical association)	0.720
PARVG	TLE5	psi-mi:“MI:0915”(physical association)	0.700
TLE5	PARVG	psi-mi:“MI:0915”(physical association)	0.700
PARVG	LIMS1	psi-mi:“MI:0914”(association)	0.640
PARVG	KLHL32	psi-mi:“MI:0915”(physical association)	0.560
MEOX2	PARVG	psi-mi:“MI:0915”(physical association)	0.560
REL	PARVG	psi-mi:“MI:0915”(physical association)	0.560
PARVG	TLE5	psi-mi:“MI:0915”(physical association)	0.560
TLE5	PARVG	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (71): PARVG (Two-hybrid), PARVG (Two-hybrid), PARVG (Two-hybrid), PARVG (Two-hybrid), USHBP1 (Two-hybrid), KLHL32 (Two-hybrid), PARVG (Affinity Capture-MS), RSU1 (Affinity Capture-MS), LIMS1 (Affinity Capture-MS), ILK (Affinity Capture-MS), POLK (Affinity Capture-MS), AARSD1 (Affinity Capture-MS), PARVG (Two-hybrid), ILK (Affinity Capture-MS), RSU1 (Affinity Capture-MS)

ESM2 similar proteins: A0JMA8, A1A535, A2AIV2, A6H8H2, A8E7C5, B7PXE3, D3ZHV2, F1REV3, O14617, O16785, O35711, O43150, O43903, O54774, P11862, P30427, Q14D04, Q5PQS3, Q5RAV3, Q5VZ89, Q61QK6, Q69YN4, Q6S5J6, Q6ZWQ0, Q6ZWR6, Q7SIG6, Q7Z3E5, Q865S1, Q8C1B1, Q8C4Q6, Q8CDA1, Q8NF91, Q8NFA0, Q91V36, Q91ZU6, Q96BJ3, Q99K01, Q9BXL7, Q9EPC1, Q9ERD8

Diamond homologs: O16785, Q1ZXH8, Q9EPC1, Q9ERD8, Q9ES46, Q9HB97, Q9HBI0, Q9HBI1, Q9NVD7, Q9VEN1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2664 predictions. Top by Δscore:

Variant	Effect	Δscore
22:44173190:AGG:A	donor_loss	1.0000
22:44173191:GGTG:G	donor_loss	1.0000
22:44187874:ATTCC:A	donor_gain	1.0000
22:44187876:TCC:T	donor_gain	1.0000
22:44187877:CC:C	donor_gain	1.0000
22:44187877:CCG:C	donor_loss	1.0000
22:44187878:CGT:C	donor_loss	1.0000
22:44187879:G:C	donor_loss	1.0000
22:44187879:G:GG	donor_gain	1.0000
22:44187880:T:A	donor_loss	1.0000
22:44189113:GA:G	acceptor_gain	1.0000
22:44189113:GAGA:G	acceptor_gain	1.0000
22:44189250:GGAGA:G	donor_gain	1.0000
22:44189251:GAGA:G	donor_gain	1.0000
22:44189251:GAGAG:G	donor_gain	1.0000
22:44189252:A:T	donor_gain	1.0000
22:44189253:GA:G	donor_gain	1.0000
22:44189255:GTAC:G	donor_gain	1.0000
22:44189285:G:T	donor_gain	1.0000
22:44190546:CCCA:C	acceptor_loss	1.0000
22:44190548:CA:C	acceptor_loss	1.0000
22:44190549:A:AG	acceptor_gain	1.0000
22:44190549:A:G	acceptor_loss	1.0000
22:44190549:AG:A	acceptor_gain	1.0000
22:44190550:G:GT	acceptor_gain	1.0000
22:44190550:GG:G	acceptor_gain	1.0000
22:44190550:GGC:G	acceptor_gain	1.0000
22:44190550:GGCAT:G	acceptor_gain	1.0000
22:44192047:A:AG	acceptor_gain	1.0000
22:44192048:G:GG	acceptor_gain	1.0000

AlphaMissense

2170 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:44198630:G:T	G241W	0.995
22:44198690:T:C	F261L	0.993
22:44198692:C:A	F261L	0.993
22:44198692:C:G	F261L	0.993
22:44198631:G:A	G241E	0.992
22:44205765:C:A	N274K	0.992
22:44205765:C:G	N274K	0.992
22:44198631:G:T	G241V	0.990
22:44187855:G:A	G75E	0.989
22:44187873:T:C	L81P	0.989
22:44189242:T:A	W126R	0.989
22:44189242:T:C	W126R	0.989
22:44198672:T:C	F255L	0.988
22:44198674:C:A	F255L	0.988
22:44198674:C:G	F255L	0.988
22:44189183:T:C	L106P	0.986
22:44198630:G:A	G241R	0.985
22:44198630:G:C	G241R	0.985
22:44198649:T:C	L247P	0.985
22:44187825:T:A	V65D	0.984
22:44187842:G:C	D71H	0.984
22:44187854:G:T	G75W	0.983
22:44198622:T:C	F238S	0.983
22:44198703:C:A	P265H	0.983
22:44198646:T:C	L246S	0.982
22:44187788:T:A	W53R	0.981
22:44187788:T:C	W53R	0.981
22:44190587:T:C	L142P	0.981
22:44205767:T:A	V275D	0.981
22:44205776:C:A	A278E	0.981

dbSNP variants (sampled 300 via entrez): RS1000000265 (22:44205008 A>G,T), RS1000066302 (22:44171451 T>C,G), RS1000102608 (22:44187951 G>A), RS1000191469 (22:44190727 C>A,G,T), RS1000207857 (22:44190882 G>C), RS1000256323 (22:44185377 C>A,T), RS1000341515 (22:44174892 C>T), RS1000395529 (22:44176739 A>G,T), RS1000462520 (22:44201416 A>C,G), RS1000578483 (22:44201560 C>T), RS1000690422 (22:44196342 G>A), RS1000769394 (22:44185644 G>A), RS1000827314 (22:44181993 A>G), RS1001030402 (22:44186742 G>T), RS1001153882 (22:44183310 CTG>C)

Disease associations

OMIM: gene MIM:608122 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002822_9	Survival in colon cancer	7.000000e-06
GCST009391_1714	Metabolite levels	1.000000e-06
GCST011983_24	Fasting glucose	5.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0000638	overall survival
EFO:0010341	cholesteryl ester 16:0 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5793 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases methylation	2
GSK-J4	decreases expression	1
beauvericin	affects cotreatment, increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
sodium arsenite	increases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
aflatoxin B2	increases methylation	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
enniatins	affects cotreatment, increases expression	1
abrine	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Caffeine	decreases phosphorylation	1
Calcitriol	decreases expression	1
Methapyrilene	increases methylation	1
Nickel	increases expression	1
Ozone	affects expression, increases abundance	1
Tretinoin	increases expression	1
Valproic Acid	increases methylation	1
Vanadates	decreases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL960403	Binding	Binding affinity to gamma-parvin in human Jurkat cells at 100 uM by Western blot analysis	A small molecule inhibitor of alpha4 integrin-dependent cell migration. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.