PAXBP1-AS1

Summary

PAXBP1-AS1 (PAXBP1 antisense RNA 1, HGNC:39603) is a long non-coding RNA gene on chromosome 21q22.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39603
Approved symbol	PAXBP1-AS1
Name	PAXBP1 antisense RNA 1
Location	21q22.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000238197
Ensembl biotype	lncRNA
Entrez	100506215
RNAcentral	URS0000759F18 — lncRNA, 3548 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000440052, ENST00000455170, ENST00000458479, ENST00000653345, ENST00000653730, ENST00000654247, ENST00000655379, ENST00000655758, ENST00000655910, ENST00000660366, ENST00000662524, ENST00000665120, ENST00000665598, ENST00000665654, ENST00000691027

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000440052 — 4 exons

Exon	Start	End
ENSE00001637352	32728139	32730661
ENSE00001710895	32738272	32738341
ENSE00001755988	32742262	32743122
ENSE00001758586	32733589	32733657

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 82.86.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6919 / max 94.6110, expressed in 688 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188827	0.8925	368
188826	0.7994	404

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	82.86	gold quality
pituitary gland	UBERON:0000007	82.30	gold quality
oviduct epithelium	UBERON:0004804	82.25	gold quality
bone marrow cell	CL:0002092	81.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.03	gold quality
monocyte	CL:0000576	80.29	gold quality
buccal mucosa cell	CL:0002336	80.13	gold quality
leukocyte	CL:0000738	79.69	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.23	gold quality
sural nerve	UBERON:0015488	78.88	gold quality
cerebellar hemisphere	UBERON:0002245	78.82	gold quality
cerebellar cortex	UBERON:0002129	78.79	gold quality
colonic epithelium	UBERON:0000397	78.67	gold quality
calcaneal tendon	UBERON:0003701	78.37	gold quality
sperm	CL:0000019	77.95	gold quality
cerebellum	UBERON:0002037	77.24	gold quality
cortical plate	UBERON:0005343	77.19	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.06	gold quality
left ovary	UBERON:0002119	76.93	gold quality
ganglionic eminence	UBERON:0004023	76.77	gold quality
right ovary	UBERON:0002118	76.57	gold quality
right lobe of thyroid gland	UBERON:0001119	75.81	gold quality
body of pancreas	UBERON:0001150	75.74	gold quality
mucosa of stomach	UBERON:0001199	75.55	gold quality
tibial nerve	UBERON:0001323	75.52	gold quality
islet of Langerhans	UBERON:0000006	75.24	gold quality
spinal cord	UBERON:0002240	75.11	gold quality
left lobe of thyroid gland	UBERON:0001120	74.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.28	silver quality
pancreas	UBERON:0001264	74.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.