PAXIP1-DT

Summary

PAXIP1-DT (PAXIP1 divergent transcript, HGNC:27328) is a long non-coding RNA gene on chromosome 7q36.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27328
Approved symbol	PAXIP1-DT
Name	PAXIP1 divergent transcript
Location	7q36.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000273344
Ensembl biotype	lncRNA
Entrez	202781
RNAcentral	URS000075BB2D — lncRNA, 2275 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000608317, ENST00000756086, ENST00000756087, ENST00000756088, ENST00000756089, ENST00000756090, ENST00000756091, ENST00000756092, ENST00000756093, ENST00000756094, ENST00000756095, ENST00000756096, ENST00000756097, ENST00000756098, ENST00000756099, ENST00000756100, ENST00000756101

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000608317 — 1 exons

Exon	Start	End
ENSE00004105799	155003419	155005703

Expression profiles

Bgee: expression breadth ubiquitous, 246 present calls, max score 94.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.0166 / max 35.8446, expressed in 1263 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82202	2.0945	1018
82203	0.9221	543

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	94.72	gold quality
thymus	UBERON:0002370	93.87	gold quality
corpus epididymis	UBERON:0004359	91.73	gold quality
upper arm skin	UBERON:0004263	91.56	gold quality
epithelial cell of pancreas	CL:0000083	91.50	silver quality
caput epididymis	UBERON:0004358	88.52	gold quality
kidney epithelium	UBERON:0004819	86.23	silver quality
cerebellar vermis	UBERON:0004720	84.85	gold quality
bronchial epithelial cell	CL:0002328	84.70	gold quality
sperm	CL:0000019	84.61	silver quality
jejunal mucosa	UBERON:0000399	84.33	gold quality
bronchus	UBERON:0002185	84.14	gold quality
cerebellar cortex	UBERON:0002129	84.09	gold quality
cerebellar hemisphere	UBERON:0002245	84.09	gold quality
cerebellum	UBERON:0002037	84.03	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.19	gold quality
right uterine tube	UBERON:0001302	83.16	gold quality
cauda epididymis	UBERON:0004360	82.93	gold quality
endothelial cell	CL:0000115	82.64	gold quality
tibialis anterior	UBERON:0001385	82.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.51	gold quality
Brodmann (1909) area 23	UBERON:0013554	81.22	gold quality
nasal cavity mucosa	UBERON:0001826	80.96	gold quality
ileal mucosa	UBERON:0000331	80.89	gold quality
renal medulla	UBERON:0000362	80.65	gold quality
jejunum	UBERON:0002115	80.65	gold quality
quadriceps femoris	UBERON:0001377	80.57	silver quality
skin of hip	UBERON:0001554	80.41	gold quality
ventricular zone	UBERON:0003053	80.40	gold quality
body of pancreas	UBERON:0001150	80.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA PAXIP1-AS1 was highly expressed in glioma and associated with poor prognosis. Highly expressed lncRNA PAXIP1-AS1 promoted glioma cell migration, invasion and angiogenesis by recruiting transcription factor ETS1 to upregulate KIF14 expression. However, its silencing inhibited migration, invasion and angiogenesis of glioma cells. (PMID:31823805)
• LncRNA PAXIP1-AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis. (PMID:34245091)
• The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation. (PMID:37225681)
• PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer. (PMID:37582104)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.