PBOV1

Summary

PBOV1 (prostate and breast cancer overexpressed 1, HGNC:21079) is a protein-coding gene on chromosome 6q23.3, encoding Prostate and breast cancer overexpressed gene 1 protein (Q9GZY1).

This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer.

Source: NCBI Gene 59351 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_021635

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21079
Approved symbol	PBOV1
Name	prostate and breast cancer overexpressed 1
Location	6q23.3
Locus type	gene with protein product
Status	Approved
Aliases	UC28, UROC28
Ensembl gene	ENSG00000254440
Ensembl biotype	protein_coding
OMIM	605669
Entrez	59351

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000527246

RefSeq mRNA: 1 — MANE Select: NM_021635 NM_021635

CCDS: CCDS5190

Canonical transcript exons

ENST00000527246 — 1 exons

Exon	Start	End
ENSE00002142146	138215986	138218491

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 63.03.

Top tissues by expression

209 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	63.03	silver quality
epithelium of nasopharynx	UBERON:0001951	62.12	gold quality
corpus callosum	UBERON:0002336	58.44	gold quality
bone marrow cell	CL:0002092	58.36	gold quality
buccal mucosa cell	CL:0002336	55.71	gold quality
oocyte	CL:0000023	55.30	gold quality
sperm	CL:0000019	54.04	gold quality
nasal cavity epithelium	UBERON:0005384	52.74	gold quality
lower lobe of lung	UBERON:0008949	52.65	silver quality
heart right ventricle	UBERON:0002080	52.17	gold quality
metanephros cortex	UBERON:0010533	51.25	gold quality
tonsil	UBERON:0002372	48.19	gold quality
metanephros	UBERON:0000081	47.97	gold quality
oviduct epithelium	UBERON:0004804	47.93	silver quality
lateral nuclear group of thalamus	UBERON:0002736	47.65	gold quality
tendon of biceps brachii	UBERON:0008188	46.84	gold quality
bone marrow	UBERON:0002371	45.54	gold quality
cardia of stomach	UBERON:0001162	45.37	gold quality
upper leg skin	UBERON:0004262	45.04	silver quality
substantia nigra pars reticulata	UBERON:0001966	44.62	gold quality
adult organism	UBERON:0007023	43.72	gold quality
skeletal muscle tissue	UBERON:0001134	43.65	gold quality
gingiva	UBERON:0001828	43.56	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
tendon	UBERON:0000043	43.17	gold quality
ventral tegmental area	UBERON:0002691	43.00	gold quality
gingival epithelium	UBERON:0001949	42.58	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
calcaneal tendon	UBERON:0003701	42.47	gold quality
germinal epithelium of ovary	UBERON:0001304	41.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.44

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

73 targeting PBOV1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-132-3P	99.73	70.56	1424
HSA-MIR-212-3P	99.73	70.65	1424
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-586	99.65	70.40	2051
HSA-MIR-6848-3P	99.64	66.49	885
HSA-MIR-885-5P	99.59	68.59	879
HSA-MIR-2113	99.58	71.22	1521
HSA-MIR-4672	99.50	71.58	2893

Literature-anchored findings (GeneRIF, showing 6)

• UROC28 mRNA expression was greater in breast cancers than in noncancerous tissues (p < 0.0001), as was ERBB2 mRNA. (PMID:12553037)
• Approximately half of the prostate tumors displayed increased copy numbers of the BMP2, BMP5, BMP7, and UC28 gene loci, which may account for their abnormal gene expression patterns in neoplastic prostate tissue. (PMID:17656261)
• Data indicate that analysis of public microarray data suggests that PBOV1 activation in tumors could be dependent on the Hedgehog signaling pathway. (PMID:23418531)
• Study shows that patients with high PBOV1 expression had longer overall survival; patients with low PBOV1 expression had shorter survival suggesting that PBOV1 may play an important role in suppressing ovarian cancer proliferation and carcinogenesis. (PMID:26549570)
• Overexpression of PBOV1 in THP-1 cells resulted in cell cycle G1 arrest, differentiation into macrophages, a marked increase in IL-10 and CXCL10 mRNA levels, and upregulation of the costimulatory molecules. (PMID:30231487)
• FBXL19AS1 promotes the progression of nasopharyngeal carcinoma by acting as a competing endogenous RNA to sponge miR431 and upregulate PBOV1. (PMID:34278444)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Prostate and breast cancer overexpressed gene 1 protein — Q9GZY1 (reviewed: Q9GZY1)

Alternative names: Protein UROC28

All UniProt accessions (1): Q9GZY1

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary, and peripheral blood leukocytes. Up-regulated expression in prostate, breast, and bladder cancer, but not in lung and colon cancer.

RefSeq proteins (1): NP_067648* (*=MANE)

Domains & families (InterPro)

UniProt features (2 total): chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9GZY1-F1	51.83	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 24 (showing top): ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, TAATTA_CHX10_01, chr6q23, CHICAS_RB1_TARGETS_CONFLUENT, KRIEG_HYPOXIA_NOT_VIA_KDM3A, NOTCH_DN.V1_DN, MIR5688, MIR495_3P, MIR4291, MIR5010_3P, MIR3978, MIR212_3P, MIR132_3P, MIR504_3P, MIR885_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (5): nucleoplasm (GO:0005654), cytosol (GO:0005829), centriolar satellite (GO:0034451), nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
nuclear lumen	1
cytoplasm	1
centrosome	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

36 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PBOV1	ESCO1	Q5FWF5	222
PBOV1	BMP5	P22003	222
PBOV1	ESCO2	Q56NI9	221
PBOV1	HHLA1	C9JL84	201
PBOV1	CEBPB	P17676	200
PBOV1	FOXA1	P55317	181
PBOV1	ISM2	Q6H9L7	176
PBOV1	EYA4	O95677	174
PBOV1	AFF4	Q9UHB7	167
PBOV1	HNRNPL	P14866	163
PBOV1	CT47A11	Q5JQC4	161
PBOV1	TMC6	Q7Z403	161
PBOV1	ATOH7	Q8N100	160
PBOV1	SOCS7	O14512	159
PBOV1	HNRNPU	Q00839	159

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A023PXH2, A8MS09, B0L3A2, B6HUQ5, G2TRK6, G2TRL6, G2TRL8, G3V211, O13536, O14599, O30141, P03935, P05678, P0CE96, P0CE97, P0CE98, P19282, P38296, P38476, P39725, P40211, P53132, P53175, P53229, P53342, P75202, P92561, Q02918, Q03864, Q04434, Q07746, Q0Q027, Q10300, Q12174, Q12225, Q12327, Q3E7B9, Q54UZ5, Q65962, Q6B108

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

63 predictions. Top by Δscore:

Variant	Effect	Δscore
6:138218300:G:GT	donor_gain	0.8500
6:138216617:T:G	acceptor_gain	0.7900
6:138216616:T:TG	acceptor_gain	0.7400
6:138218300:G:T	acceptor_gain	0.6800
6:138218401:CTA:C	donor_gain	0.5600
6:138216752:T:G	donor_gain	0.5400
6:138218400:A:AC	donor_gain	0.5300
6:138218401:C:CC	donor_gain	0.5300
6:138218397:T:C	donor_gain	0.4600
6:138216523:AT:A	donor_gain	0.4200
6:138218469:GCCAC:G	donor_loss	0.4100
6:138218470:CCA:C	donor_loss	0.4100
6:138218471:CACCT:C	donor_loss	0.4100
6:138218472:A:T	donor_loss	0.4100
6:138218473:C:CC	donor_loss	0.4100
6:138218474:C:G	donor_loss	0.4000
6:138216861:G:T	donor_gain	0.3900
6:138218291:T:TA	donor_gain	0.3900
6:138218292:A:AA	donor_gain	0.3900
6:138217399:CATAG:C	acceptor_gain	0.3700
6:138218486:AAGGT:A	donor_gain	0.3600
6:138217399:C:T	acceptor_gain	0.3500
6:138218401:C:CT	donor_gain	0.3500
6:138218402:T:TT	donor_gain	0.3500
6:138218475:T:A	donor_loss	0.3400
6:138218475:T:TA	donor_gain	0.3400
6:138218402:T:C	donor_gain	0.3300
6:138218403:A:AC	donor_gain	0.3300
6:138218404:C:CC	donor_gain	0.3300
6:138218456:TA:T	donor_gain	0.3300

AlphaMissense

877 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:138218237:A:C	F53L	0.885
6:138218237:A:T	F53L	0.885
6:138218239:A:G	F53L	0.885
6:138218300:G:C	F32L	0.806
6:138218300:G:T	F32L	0.806
6:138218302:A:G	F32L	0.806
6:138218192:G:C	F68L	0.788
6:138218192:G:T	F68L	0.788
6:138218194:A:G	F68L	0.788
6:138218028:A:G	L123P	0.758
6:138218384:G:C	F4L	0.754
6:138218384:G:T	F4L	0.754
6:138218386:A:G	F4L	0.754
6:138218145:A:G	L84S	0.751
6:138218251:A:G	C49R	0.746
6:138218032:A:G	C122R	0.716
6:138218058:A:G	L113S	0.699
6:138218238:A:G	F53S	0.684
6:138218252:G:C	F48L	0.664
6:138218252:G:T	F48L	0.664
6:138218254:A:G	F48L	0.664
6:138218249:G:C	C49W	0.662
6:138218157:A:C	I80S	0.640
6:138218238:A:C	F53C	0.640
6:138218324:T:A	K24N	0.628
6:138218324:T:G	K24N	0.628
6:138218157:A:T	I80N	0.623
6:138218037:T:A	E120V	0.616
6:138218327:T:A	R23S	0.616
6:138218327:T:G	R23S	0.616

dbSNP variants (sampled 300 via entrez): RS1001295795 (6:138217649 G>A), RS1002749961 (6:138215896 G>A), RS1004831125 (6:138219654 G>T), RS1004881953 (6:138219308 G>A), RS1005700290 (6:138216558 T>C), RS1006538098 (6:138215667 A>C), RS1008180379 (6:138216781 A>G), RS1008213204 (6:138217132 A>C), RS1008548320 (6:138218443 T>A,C), RS1009048883 (6:138219984 T>A), RS1009122294 (6:138220181 T>C), RS1009812438 (6:138219952 G>A), RS1010254073 (6:138219620 T>C), RS1011739316 (6:138219982 AT>A,ATT), RS1012183567 (6:138220201 C>A,T)

Disease associations

OMIM: gene MIM:605669 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Estradiol	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.