PBX2

Summary

PBX2 (PBX homeobox 2, HGNC:8633) is a protein-coding gene on chromosome 6p21.32, encoding Pre-B-cell leukemia transcription factor 2 (P40425). Transcriptional activator that binds the sequence 5’-ATCAATCAA-3'.

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.

Source: NCBI Gene 5089 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 59 total
• MANE Select transcript: NM_002586

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8633
Approved symbol	PBX2
Name	PBX homeobox 2
Location	6p21.32
Locus type	gene with protein product
Status	Approved
Aliases	G17, HOX12, PBX2MHC
Ensembl gene	ENSG00000204304
Ensembl biotype	protein_coding
OMIM	176311
Entrez	5089

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 retained_intron, 1 protein_coding

ENST00000375050, ENST00000478678, ENST00000480254, ENST00000495300, ENST00000496171

RefSeq mRNA: 1 — MANE Select: NM_002586 NM_002586

CCDS: CCDS4748

Canonical transcript exons

ENST00000375050 — 9 exons

Exon	Start	End
ENSE00001348644	32184733	32186474
ENSE00001635556	32189695	32190202
ENSE00001739809	32186604	32186690
ENSE00001759610	32186813	32186901
ENSE00001795541	32187242	32187395
ENSE00003530237	32187647	32187782
ENSE00003532154	32188723	32188796
ENSE00003539392	32187966	32188156
ENSE00003585775	32188257	32188504

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 98.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.3840 / max 126.8765, expressed in 1787 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72921	15.3840	1787
72922	0.1781	61
72923	0.1302	37
72924	0.0698	20

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	98.14	gold quality
left lobe of thyroid gland	UBERON:0001120	97.99	gold quality
granulocyte	CL:0000094	97.98	gold quality
thyroid gland	UBERON:0002046	97.88	gold quality
right ovary	UBERON:0002118	97.60	gold quality
spleen	UBERON:0002106	97.58	gold quality
body of uterus	UBERON:0009853	97.56	gold quality
pituitary gland	UBERON:0000007	97.49	gold quality
left ovary	UBERON:0002119	97.46	gold quality
ovary	UBERON:0000992	97.29	gold quality
adenohypophysis	UBERON:0002196	97.26	gold quality
left uterine tube	UBERON:0001303	97.25	gold quality
blood	UBERON:0000178	97.19	gold quality
right uterine tube	UBERON:0001302	97.15	gold quality
right adrenal gland cortex	UBERON:0035827	96.96	gold quality
right adrenal gland	UBERON:0001233	96.92	gold quality
metanephros cortex	UBERON:0010533	96.87	gold quality
endocervix	UBERON:0000458	96.81	gold quality
myometrium	UBERON:0001296	96.79	gold quality
vermiform appendix	UBERON:0001154	96.77	gold quality
placenta	UBERON:0001987	96.70	gold quality
lymph node	UBERON:0000029	96.69	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.69	gold quality
fundus of stomach	UBERON:0001160	96.67	gold quality
fallopian tube	UBERON:0003889	96.63	gold quality
gall bladder	UBERON:0002110	96.52	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.44	gold quality
left adrenal gland cortex	UBERON:0035825	96.37	gold quality
prostate gland	UBERON:0002367	96.31	gold quality
left adrenal gland	UBERON:0001234	96.26	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6911	no	10.40
E-ANND-3	no	1.24

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA1113.1	PBX2	TALE-type homeo domain factors
MA1113.2	PBX2	TALE-type homeo domain factors
MA1113.3	PBX2	TALE-type homeo domain factors

JASPAR matrix evidence (PMIDs): PMID:10082572, PMID:12054735

miRNA regulators (miRDB)

179 targeting PBX2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-LET-7D-5P	99.96	71.76	1632

Literature-anchored findings (GeneRIF, showing 11)

• a PBX2 Regulatory Element PRE-1048 has been identified which contains a novel DNA-binding sequence and mediates significant activation of the HOX11 gene in K562 cells. (PMID:12054735)
• these studies demonstrate that the homeodomain proteins, MEIS1, PBX1B, and PBX2, play an important role in megakaryocytic gene expression. (PMID:12609849)
• PBX2 increases in F9 teratocarcinoma cells because PREP-1 prevents its degradation (PMID:12871956)
• PBX2 expression pattern is similar to HOXA7 expression in ovarian follicular development (PMID:18973687)
• Expression levels of PBX2 and VCP were immunohistochemically examined and compared with each other in 206 non-small cell lung cancer cases (PMID:19356220)
• Pre B cell leukemia homeobox 2 has a role in poor prognosis of gastric adenocarcinoma and esophageal squamous cell carcinoma (PMID:20126986)
• a high level of PBX2 is a poor prognosticator for disease-free survival and overall survival in gingival squamous cell carcinoma (PMID:22374608)
• findings suggest the disruption of the HOXB7/PBX2 complexes, miR-221&222 inhibition or even better their combination, as innovative therapeutic approaches (PMID:23400877)
• miR19153p functions as a silencer of apoptosis, which regulates lung cancer apoptosis via targeting DRG2/PBX2. (PMID:26572100)
• The findings from the present study that a SNP of the PBX2 gene in the MHC region (at 6p21.3) was associated with allergic rhinitis (AR) in allele and genotypic analysis suggests a new susceptibility gene for AR in the MHC region and another gene associated with both asthma and AR in Chinese subjects. (PMID:26852910)
• Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer. (PMID:33535170)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
mus_musculus	Pbx2	ENSMUSG00000034673
rattus_norvegicus	Pbx2	ENSRNOG00000000440
drosophila_melanogaster	exd	FBGN0000611
drosophila_melanogaster	hth	FBGN0001235
drosophila_melanogaster	vis	FBGN0033748
drosophila_melanogaster	achi	FBGN0033749
caenorhabditis_elegans		WBGENE00000443
caenorhabditis_elegans		WBGENE00006796
caenorhabditis_elegans		WBGENE00017690

Paralogs (13): MEIS3 (ENSG00000105419), PBX4 (ENSG00000105717), TGIF2 (ENSG00000118707), MEIS2 (ENSG00000134138), MEIS1 (ENSG00000143995), TGIF2LX (ENSG00000153779), PKNOX1 (ENSG00000160199), PKNOX2 (ENSG00000165495), PBX3 (ENSG00000167081), TGIF2LY (ENSG00000176679), TGIF1 (ENSG00000177426), PBX1 (ENSG00000185630), MEIS3P2 (ENSG00000188013)

Protein

Protein identifiers

Pre-B-cell leukemia transcription factor 2 — P40425 (reviewed: P40425)

Alternative names: Homeobox protein PBX2, Protein G17

All UniProt accessions (2): A0A024RCR3, P40425

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional activator that binds the sequence 5’-ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1.

Subunit / interactions. Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1.

Subcellular location. Nucleus.

Tissue specificity. Ubiquitously expressed.

Similarity. Belongs to the TALE/PBX homeobox family.

RefSeq proteins (1): NP_002577* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR005542	PBX_PBC_dom	Domain
IPR008422	KN_HD	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR050224	TALE_homeobox	Family

Pfam: PF03792, PF05920

UniProt features (17 total): modified residue 5, region of interest 5, compositionally biased region 3, chain 1, domain 1, sequence conflict 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P40425-F1	71.30	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 136, 151, 159, 330, 395

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 267 (showing top): HOFMANN_CELL_LYMPHOMA_UP, SP3_Q3, RIZ_ERYTHROID_DIFFERENTIATION_CCNE1, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_NEUROGENESIS, HNF1_Q6, BOYLAN_MULTIPLE_MYELOMA_D_DN, GOBP_PROXIMAL_DISTAL_PATTERN_FORMATION, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_DN, GOBP_APPENDAGE_DEVELOPMENT, GOBP_HEAD_DEVELOPMENT, HNF1_C, TGGNNNNNNKCCAR_UNKNOWN

GO Biological Process (9): eye development (GO:0001654), brain development (GO:0007420), animal organ morphogenesis (GO:0009887), proximal/distal pattern formation (GO:0009954), embryonic limb morphogenesis (GO:0030326), positive regulation of transcription by RNA polymerase II (GO:0045944), embryonic organ development (GO:0048568), neuron development (GO:0048666), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (8): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), chromatin binding (GO:0003682), DNA-binding transcription factor binding (GO:0140297), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), transcription regulator complex (GO:0005667)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
animal organ development	3
regulation of transcription by RNA polymerase II	2
transcription cis-regulatory region binding	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
binding	2
sensory organ development	1
visual system development	1
central nervous system development	1
head development	1
anatomical structure morphogenesis	1
regionalization	1
limb morphogenesis	1
embryonic appendage morphogenesis	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
embryo development	1
neuron differentiation	1
cell development	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
transcription factor binding	1
nucleic acid binding	1
regulation of DNA-templated transcription	1
transcription regulator activity	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

998 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PBX2	PKNOX1	P55347	808
PBX2	AGPAT1	Q99943	805
PBX2	HOXA10	P31260	795
PBX2	SLC38A2	Q96QD8	760
PBX2	HOXB7	P09629	749
PBX2	NOTCH4	Q99466	738
PBX2	SLC38A1	Q9H2H9	719
PBX2	HOXA9	P31269	687
PBX2	CREBBP	Q92793	665
PBX2	MEIS3	Q99687	646
PBX2	MEIS2	O14770	614
PBX2	AGER	Q15109	597
PBX2	AGPAT2	O15120	588
PBX2	TLX1	P31314	533
PBX2	EMX2	Q04743	524

IntAct

150 interactions, top by confidence:

A	B	Type	Score
STK25	STRN	psi-mi:“MI:0914”(association)	0.900
PKNOX1	PBX2	psi-mi:“MI:0915”(physical association)	0.740
PBX2	PKNOX1	psi-mi:“MI:0915”(physical association)	0.740
AFF4	ELL2	psi-mi:“MI:0914”(association)	0.730
MEIS2	PBX1	psi-mi:“MI:0914”(association)	0.660
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
PBX2	RIPPLY2	psi-mi:“MI:0915”(physical association)	0.630
RIPPLY2	PBX2	psi-mi:“MI:0915”(physical association)	0.630
MAB21L1	PBX2	psi-mi:“MI:0915”(physical association)	0.620
PBX2	HOXA1	psi-mi:“MI:0915”(physical association)	0.560
PBX2	CARD9	psi-mi:“MI:0915”(physical association)	0.560
CARD9	PBX2	psi-mi:“MI:0915”(physical association)	0.560
HOXC8	PBX2	psi-mi:“MI:0915”(physical association)	0.560
PBX2	PPFIBP1	psi-mi:“MI:0915”(physical association)	0.560
HOXB5	PBX2	psi-mi:“MI:0915”(physical association)	0.560
PBX2	FAM90A1	psi-mi:“MI:0915”(physical association)	0.560
PBX2	BFSP2	psi-mi:“MI:0915”(physical association)	0.560
PBX2	EFHC1	psi-mi:“MI:0915”(physical association)	0.560
HOXC9	PBX2	psi-mi:“MI:0915”(physical association)	0.560
PBX2	HOXC5	psi-mi:“MI:0915”(physical association)	0.560
PBX2	BRMS1L	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (100): PBX2 (Two-hybrid), CARD9 (Two-hybrid), PBX2 (Affinity Capture-RNA), PBX2 (Affinity Capture-RNA), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS), PBX2 (Affinity Capture-MS)

ESM2 similar proteins: A3KMR8, A7Z017, B3DM47, B4R090, D3ZNT6, O35317, O35984, O42290, O57342, O75030, O75444, P10083, P23091, P25932, P40424, P40425, P40426, P41778, P54841, P54842, P54843, P54844, P56224, P57102, P61295, P61296, P79745, P79746, Q05192, Q0V9K1, Q27350, Q2PFS4, Q32NP8, Q4U1U2, Q504L8, Q61039, Q6DE84, Q6PFG8, Q789F3, Q7RTU3

Diamond homologs: A1YER0, A2D5H2, A6NDR6, A8K0S8, A8WL06, B3DM47, B4F6V6, O00470, O04134, O04135, O14770, O17894, O22299, O35317, O35984, O42406, O46339, O65034, O73916, O80416, O93307, O95343, O95475, P10842, P24345, P40424, P40425, P40426, P40427, P41778, P41779, P41817, P46608, P46609, P46639, P46640, P48731, P53147, P56661, P56662

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
PBX2	“up-regulates quantity by expression”	EMX2	“transcriptional regulation”
PBXIP1	“down-regulates activity”	PBX2	binding
PBX2	“down-regulates quantity by repression”	FGF8	“transcriptional regulation”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 101 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
eye development	8	31.2×	1e-07
anatomical structure morphogenesis	9	13.9×	5e-06
anterior/posterior pattern specification	6	12.1×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1410 predictions. Top by Δscore:

Variant	Effect	Δscore
6:32187286:C:CA	donor_gain	1.0000
6:32187300:CA:C	donor_gain	1.0000
6:32187300:CACGG:C	donor_gain	1.0000
6:32187331:T:TA	donor_gain	1.0000
6:32187345:T:A	donor_gain	1.0000
6:32187391:GAGAC:G	acceptor_gain	1.0000
6:32187393:GAC:G	acceptor_gain	1.0000
6:32187394:AC:A	acceptor_gain	1.0000
6:32187395:CC:C	acceptor_gain	1.0000
6:32187396:C:CC	acceptor_gain	1.0000
6:32187643:ATACC:A	donor_loss	1.0000
6:32187644:TAC:T	donor_loss	1.0000
6:32187645:ACCTG:A	donor_loss	1.0000
6:32187646:C:CT	donor_loss	1.0000
6:32187780:CGT:C	acceptor_gain	1.0000
6:32187783:C:CC	acceptor_gain	1.0000
6:32187960:GCCCA:G	donor_loss	1.0000
6:32187961:CCCA:C	donor_loss	1.0000
6:32187962:CCAC:C	donor_loss	1.0000
6:32187963:CACCT:C	donor_loss	1.0000
6:32187965:C:CT	donor_loss	1.0000
6:32188152:CATGC:C	acceptor_gain	1.0000
6:32188253:TTACC:T	donor_loss	1.0000
6:32188255:A:AC	donor_gain	1.0000
6:32188256:C:CC	donor_gain	1.0000
6:32188256:CCTG:C	donor_gain	1.0000
6:32188526:T:C	acceptor_gain	1.0000
6:32186409:C:CA	donor_gain	0.9900
6:32187297:TGA:T	donor_gain	0.9900
6:32187299:A:AC	donor_gain	0.9900

AlphaMissense

2808 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:32187329:C:G	A313P	1.000
6:32187351:G:C	N305K	1.000
6:32187351:G:T	N305K	1.000
6:32187354:T:A	K304N	1.000
6:32187354:T:G	K304N	1.000
6:32187355:T:A	K304I	1.000
6:32187355:T:G	K304T	1.000
6:32187356:T:C	K304E	1.000
6:32187357:C:A	K303N	1.000
6:32187357:C:G	K303N	1.000
6:32187358:T:A	K303M	1.000
6:32187358:T:G	K303T	1.000
6:32187359:T:C	K303E	1.000
6:32187361:T:C	Y302C	1.000
6:32187361:T:G	Y302S	1.000
6:32187362:A:C	Y302D	1.000
6:32187362:A:G	Y302H	1.000
6:32187362:A:T	Y302N	1.000
6:32187364:C:G	R301P	1.000
6:32187364:C:T	R301H	1.000
6:32187365:G:A	R301C	1.000
6:32187365:G:C	R301G	1.000
6:32187365:G:T	R301S	1.000
6:32187367:A:C	I300S	1.000
6:32187367:A:G	I300T	1.000
6:32187367:A:T	I300N	1.000
6:32187369:C:A	R299S	1.000
6:32187369:C:G	R299S	1.000
6:32187370:C:A	R299M	1.000
6:32187370:C:G	R299T	1.000

dbSNP variants (sampled 300 via entrez): RS1000 (6:32186118 T>C), RS1000286697 (6:32184644 C>A), RS1000337149 (6:32184909 C>T), RS1001 (6:32186196 A>G), RS1001508058 (6:32184697 G>A), RS1001796081 (6:32190465 C>G,T), RS1002 (6:32186240 G>A,C), RS1002013736 (6:32189033 C>T), RS1002210751 (6:32190532 A>G), RS1003229811 (6:32187462 G>A), RS1003586041 (6:32191890 G>A), RS1003637966 (6:32187178 T>C), RS1004095 (6:32185632 A>C), RS1004674647 (6:32190731 C>T), RS1005024340 (6:32190344 G>A)

Disease associations

OMIM: gene MIM:176311 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, affects cotreatment, increases expression, decreases expression	7
Acetaminophen	decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
coumarin	decreases phosphorylation	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
entinostat	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
belinostat	decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Panobinostat	affects cotreatment, affects expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Caffeine	increases phosphorylation	1
Carmustine	decreases expression	1
Cisplatin	affects expression, affects cotreatment	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Flavonoids	increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Methotrexate	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Niclosamide	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_GZ92	K562 eGFP-PBX2	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.