PCAT14

Summary

PCAT14 (prostate cancer associated transcript 14, HGNC:48977) is a long non-coding RNA gene on chromosome 22q11.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48977
Approved symbol	PCAT14
Name	prostate cancer associated transcript 14
Location	22q11.23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000280623
Ensembl biotype	lncRNA
Entrez	101978785
RNAcentral	URS000075EBBE — lncRNA, 1201 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000626825, ENST00000627127, ENST00000629869, ENST00000738196

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000626825 — 4 exons

Exon	Start	End
ENSE00003769612	23538761	23538838
ENSE00003772626	23536899	23537136
ENSE00003773546	23546486	23547167
ENSE00003774923	23544228	23544306

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 83.37.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2318 / max 61.0750, expressed in 74 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191315	0.2190	72
209416	0.0129	6

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.15	gold quality
endometrium	UBERON:0001295	74.67	gold quality
right uterine tube	UBERON:0001302	74.37	gold quality
prostate gland	UBERON:0002367	73.11	gold quality
sural nerve	UBERON:0015488	72.36	gold quality
left ovary	UBERON:0002119	72.00	gold quality
ovary	UBERON:0000992	70.96	gold quality
thymus	UBERON:0002370	70.30	silver quality
left lobe of thyroid gland	UBERON:0001120	68.11	gold quality
right lobe of thyroid gland	UBERON:0001119	67.99	gold quality
right ovary	UBERON:0002118	67.87	gold quality
thyroid gland	UBERON:0002046	67.78	gold quality
quadriceps femoris	UBERON:0001377	67.36	gold quality
ventricular zone	UBERON:0003053	66.21	gold quality
cerebellar vermis	UBERON:0004720	64.61	gold quality
fallopian tube	UBERON:0003889	64.50	gold quality
adrenal tissue	UBERON:0018303	62.49	gold quality
right lung	UBERON:0002167	61.70	gold quality
cortical plate	UBERON:0005343	60.86	gold quality
testis	UBERON:0000473	60.30	gold quality
left uterine tube	UBERON:0001303	60.24	gold quality
ganglionic eminence	UBERON:0004023	60.03	gold quality
right testis	UBERON:0004534	60.02	gold quality
left testis	UBERON:0004533	58.20	gold quality
kidney	UBERON:0002113	57.00	gold quality
pituitary gland	UBERON:0000007	56.81	gold quality
endocervix	UBERON:0000458	56.73	gold quality
right adrenal gland	UBERON:0001233	56.73	gold quality
right adrenal gland cortex	UBERON:0035827	56.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Using RNA-sequencing data we identify PCAT14, a novel prostate cancer and lineage-specific lncRNA. PCAT14 is highly expressed in low grade disease and loss of PCAT14 predicts for disease aggressiveness and recurrence. (PMID:27566105)
• Results demonstrate that PCAT-14 expression is associated with hepatocellular carcinoma (HCC), metastasis, tumor size, and TNM stage. Also, PCAT-14 promotes cell invasion and proliferation, and inhibits miR-372 expression by inducing methylation of CpG islands in the miR-372 promoter. In addition, PCAT-14 regulates ATAD2 expression and activation of Hedgehog pathway in HCC cells, depending on miR-372. (PMID:28415780)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.