PCAT18

Summary

PCAT18 (prostate cancer associated transcript 18, HGNC:49211) is a long non-coding RNA gene on chromosome 18q11.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 728606 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49211
Approved symbol	PCAT18
Name	prostate cancer associated transcript 18
Location	18q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC01092
Ensembl gene	ENSG00000265369
Ensembl biotype	lncRNA
OMIM	617647
Entrez	728606
RNAcentral	URS000016073B — lncRNA, 2598 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000579458, ENST00000830732, ENST00000830733, ENST00000830734, ENST00000830735

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579458 — 2 exons

Exon	Start	End
ENSE00004245497	26703392	26703783
ENSE00004245500	26687621	26689971

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 68.82.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4311 / max 161.1493, expressed in 49 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
171457	0.3838	46
171458	0.0399	16
171455	0.0054	3
171456	0.0019	1

Top tissues by expression

190 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	68.82	silver quality
minor salivary gland	UBERON:0001830	66.47	gold quality
body of stomach	UBERON:0001161	66.46	gold quality
stomach	UBERON:0000945	64.50	gold quality
mouth mucosa	UBERON:0003729	62.68	gold quality
saliva-secreting gland	UBERON:0001044	62.31	gold quality
cortical plate	UBERON:0005343	57.67	silver quality
fundus of stomach	UBERON:0001160	57.55	gold quality
right lobe of thyroid gland	UBERON:0001119	56.92	gold quality
left lobe of thyroid gland	UBERON:0001120	56.56	gold quality
prostate gland	UBERON:0002367	56.28	gold quality
thyroid gland	UBERON:0002046	55.67	gold quality
gall bladder	UBERON:0002110	55.15	gold quality
right lobe of liver	UBERON:0001114	52.28	gold quality
calcaneal tendon	UBERON:0003701	51.91	silver quality
mucosa of transverse colon	UBERON:0004991	51.81	gold quality
monocyte	CL:0000576	51.46	silver quality
right uterine tube	UBERON:0001302	51.26	gold quality
prefrontal cortex	UBERON:0000451	51.18	gold quality
rectum	UBERON:0001052	50.70	gold quality
Brodmann (1909) area 9	UBERON:0013540	49.95	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.96	gold quality
tonsil	UBERON:0002372	48.82	gold quality
putamen	UBERON:0001874	48.41	gold quality
right hemisphere of cerebellum	UBERON:0014890	47.63	gold quality
islet of Langerhans	UBERON:0000006	47.60	gold quality
right frontal lobe	UBERON:0002810	47.51	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	47.44	gold quality
nucleus accumbens	UBERON:0001882	47.20	gold quality
caudate nucleus	UBERON:0001873	47.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.09

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• tissue-specific down-regulation of PCAT18 and LINC01133 in gastric and other gastrointestinal cancers imply that these long noncoding RNAs may have a tumor suppressive function in the development of these tumor entities. (PMID:30518158)
• Over-expressed lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through regulation of miR-135b/CLDN11 (PMID:32119960)
• PCAT18, as a novel differentially regulated long noncoding RNA in adult acute myeloid leukemia patients revealed by next-generation sequencing. (PMID:33006448)
• lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p. (PMID:34787047)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.