PCAT19

Summary

PCAT19 (prostate cancer associated transcript 19, HGNC:49593) is a long non-coding RNA gene on chromosome 19q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49593
Approved symbol	PCAT19
Name	prostate cancer associated transcript 19
Location	19q13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC01190
Ensembl gene	ENSG00000267107
Ensembl biotype	lncRNA
OMIM	618192
Entrez	100505495
RNAcentral	URS0000A776B1 — lncRNA, 3489 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 43 — 43 lncRNA

ENST00000588495, ENST00000594315, ENST00000595063, ENST00000595837, ENST00000597702, ENST00000598215, ENST00000599801, ENST00000650748, ENST00000650788, ENST00000650804, ENST00000650991, ENST00000651016, ENST00000651156, ENST00000651285, ENST00000651291, ENST00000651464, ENST00000651572, ENST00000651651, ENST00000651712, ENST00000651789, ENST00000651806, ENST00000651979, ENST00000652015, ENST00000652127, ENST00000652144, ENST00000652160, ENST00000652279, ENST00000652333, ENST00000652406, ENST00000652484, ENST00000652511, ENST00000652558, ENST00000656967, ENST00000664904, ENST00000668141, ENST00000783813, ENST00000783814, ENST00000783815, ENST00000783816, ENST00000783817, ENST00000783818, ENST00000783819, ENST00000783820

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000588495 — 4 exons

Exon	Start	End
ENSE00002843313	41479081	41479284
ENSE00002882507	41494540	41495427
ENSE00002888114	41454164	41456487
ENSE00002950105	41500584	41500644

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 96.77.

FANTOM5 (CAGE): breadth broad, TPM avg 2.6838 / max 108.7914, expressed in 308 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181072	1.2188	208
181074	0.8942	176
181073	0.3818	75
181071	0.0963	56
181069	0.0806	13
181070	0.0121	7

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oviduct epithelium	UBERON:0004804	96.77	gold quality
right lung	UBERON:0002167	96.42	gold quality
upper lobe of left lung	UBERON:0008952	93.28	gold quality
upper lobe of lung	UBERON:0008948	92.64	gold quality
right uterine tube	UBERON:0001302	92.34	gold quality
omental fat pad	UBERON:0010414	91.79	gold quality
peritoneum	UBERON:0002358	91.75	gold quality
adipose tissue of abdominal region	UBERON:0007808	91.10	gold quality
fallopian tube	UBERON:0003889	90.14	gold quality
lung	UBERON:0002048	89.09	gold quality
subcutaneous adipose tissue	UBERON:0002190	89.01	gold quality
apex of heart	UBERON:0002098	88.94	gold quality
spleen	UBERON:0002106	88.53	gold quality
adipose tissue	UBERON:0001013	87.04	gold quality
heart left ventricle	UBERON:0002084	85.88	gold quality
cardiac ventricle	UBERON:0002082	85.31	gold quality
left lobe of thyroid gland	UBERON:0001120	84.56	gold quality
thyroid gland	UBERON:0002046	84.23	gold quality
left uterine tube	UBERON:0001303	84.08	gold quality
right lobe of thyroid gland	UBERON:0001119	83.73	gold quality
colonic epithelium	UBERON:0000397	83.24	gold quality
heart	UBERON:0000948	83.22	gold quality
right atrium auricular region	UBERON:0006631	83.05	gold quality
endocervix	UBERON:0000458	83.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.77	gold quality
smooth muscle tissue	UBERON:0001135	82.44	gold quality
body of uterus	UBERON:0009853	82.37	gold quality
cardiac atrium	UBERON:0002081	82.29	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.01	gold quality
visceral pleura	UBERON:0002401	81.16	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-126	yes	1119.78
E-MTAB-10662	yes	744.10
E-MTAB-10287	yes	74.72
E-ANND-3	yes	32.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• rs11672691, a Prostate Cancer (PCa) risk SNP, has been associated with the diagnosis of aggressive and fatal PCa. Patients with homozygous risk allele genotype G showed significantly shorter biochemical recurrence-free survival compared to patients with the non-risk allele genotype A (p = 0.032), suggesting a role for the risk SNP in disease progression after local therapy. (PMID:30033362)
• lncRNA PCAT19 promotes the proliferation of laryngocarcinoma cells via modulation of the miR-182/PDK4 axis. (PMID:30868666)
• Suppression of long non-coding RNA PCAT19 inhibits glioma cell proliferation and invasion, and increases cell apoptosis through regulation of MELK targeted by miR-142-5p. (PMID:32980991)
• PCAT19 Regulates the Proliferation and Apoptosis of Lung Cancer Cells by Inhibiting miR-25-3p via Targeting the MAP2K4 Signal Axis. (PMID:35615401)
• Long Non-Coding RNA PCAT19 Regulates the Malignant Progression of Bladder Cancer through the miR-335-5p/IER2 Axis. (PMID:36017918)
• Inhibition of lncRNA PCAT19 promotes breast cancer proliferation. (PMID:36992525)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.