PCAT2

Summary

PCAT2 (prostate cancer associated transcript 2, HGNC:45089) is a long non-coding RNA gene on chromosome 8q24.21.

At a glance

• GWAS associations: 2

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45089
Approved symbol	PCAT2
Name	prostate cancer associated transcript 2
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	PCA2, TCONS_00015167
OMIM	617678
Entrez	103164619
RNAcentral	URS000018F875 — lncRNA, 575 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Expression pattern of PCAT1, PCAT2, and PCAT5 lncRNAs and their value as diagnostic biomarkers in patients with gastric cancer. (PMID:37392552)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000210070 (8:127079922 A>G), RS1000262268 (8:127080453 T>C), RS1000633698 (8:127075337 T>C), RS1000698630 (8:127074326 C>G,T), RS1001151882 (8:127074616 A>C,G,T), RS1001565252 (8:127081865 TC>T), RS1001626247 (8:127076059 C>T), RS1001861030 (8:127073867 A>G), RS1001932539 (8:127081583 T>C), RS1002515955 (8:127072751 C>A), RS1002683142 (8:127084167 A>C,G,T), RS1002867489 (8:127072435 A>G), RS1003015770 (8:127072444 C>A,T), RS1003094620 (8:127078278 T>G), RS1003560694 (8:127082683 A>G)

Disease associations

OMIM: gene MIM:617678 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004747_17	Lung cancer in never smokers	9.000000e-06
GCST90020026_747	Hip index	6.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
OTX015	decreases expression	1
mivebresib	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Gold Compounds	increases expression	1
Okadaic Acid	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.