PCAT4

Summary

PCAT4 (prostate cancer associated transcript 4, HGNC:24853) is a long non-coding RNA gene on chromosome 4q21.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24853
Approved symbol	PCAT4
Name	prostate cancer associated transcript 4
Location	4q21.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	GDEP, PCAN1, PCA4
Ensembl gene	ENSG00000251321
Ensembl biotype	lncRNA
OMIM	609717
Entrez	118425
RNAcentral	URS00004666D4 — lncRNA, 2091 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000504263, ENST00000514836, ENST00000775423, ENST00000775424

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000504263 — 2 exons

Exon	Start	End
ENSE00004142265	79861290	79863247
ENSE00004142269	79827323	79827603

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 91.70.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0582 / max 58.6290, expressed in 6 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
48504	0.0582	6

Top tissues by expression

201 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	91.70	gold quality
prostate gland	UBERON:0002367	85.47	gold quality
oocyte	CL:0000023	71.09	silver quality
tibialis anterior	UBERON:0001385	64.80	silver quality
secondary oocyte	CL:0000655	63.46	silver quality
pancreatic ductal cell	CL:0002079	60.45	silver quality
right hemisphere of cerebellum	UBERON:0014890	59.77	gold quality
calcaneal tendon	UBERON:0003701	59.66	gold quality
monocyte	CL:0000576	58.89	gold quality
ileal mucosa	UBERON:0000331	57.62	silver quality
epithelium of nasopharynx	UBERON:0001951	56.75	gold quality
islet of Langerhans	UBERON:0000006	55.84	gold quality
deltoid	UBERON:0001476	55.74	gold quality
upper leg skin	UBERON:0004262	55.27	silver quality
muscle of leg	UBERON:0001383	55.25	gold quality
right lobe of liver	UBERON:0001114	55.16	gold quality
epithelial cell of pancreas	CL:0000083	54.70	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
cerebellar hemisphere	UBERON:0002245	53.69	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
skin of hip	UBERON:0001554	53.12	silver quality
gastrocnemius	UBERON:0001388	53.06	gold quality
cerebellar vermis	UBERON:0004720	51.62	gold quality
cardiac atrium	UBERON:0002081	50.47	gold quality
pancreas	UBERON:0001264	50.40	gold quality
myocardium	UBERON:0002349	50.25	gold quality
prefrontal cortex	UBERON:0000451	49.05	gold quality
right atrium auricular region	UBERON:0006631	48.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NKX3-1

Literature-anchored findings (GeneRIF, showing 3)

• Study reports cloning a 2.6-kb fragment of the 5’ flanking region of the PCAN1 gene which represented promoter activity and was regulated by NKX3.1, p53, Sp1, Pten and 9-cis-RA in the luciferase reporter assay. (PMID:17468839)
• a 1.5 kb prostate-specific promoter from the proximal region of the GDEP gene was identified. A smaller 0.5 kb promoter exhibited minimal activity in the retinoblastoma cell line Y79, but not in the prostate cells tested. (PMID:18188713)
• These results suggested that two functional NKX3.1 binding sites located at -1848 to -1836 and -803 to -791 upstream of the PCAN1 gene were involved in the positive regulation of PCAN1 gene transcription by NKX3.1. (PMID:18454873)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.