PCAT5

Summary

PCAT5 (prostate cancer associated transcript 5, HGNC:48665) is a long non-coding RNA gene on chromosome 10p11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48665
Approved symbol	PCAT5
Name	prostate cancer associated transcript 5
Location	10p11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	TPCAT-10-36067
Ensembl gene	ENSG00000280719
Ensembl biotype	lncRNA
Entrez	102578074
RNAcentral	URS0000003826 — lncRNA, 3550 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000626667, ENST00000846346

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000626667 — 3 exons

Exon	Start	End
ENSE00003768047	35798029	35800920
ENSE00003769037	35796606	35797049
ENSE00003771015	35778302	35778515

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 80.71.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.71	gold quality
monocyte	CL:0000576	69.83	gold quality
liver	UBERON:0002107	62.02	silver quality
muscle of leg	UBERON:0001383	61.06	gold quality
blood	UBERON:0000178	52.56	silver quality
gastrocnemius	UBERON:0001388	49.06	silver quality
anterior cingulate cortex	UBERON:0009835	48.40	silver quality
prostate gland	UBERON:0002367	47.96	gold quality
thyroid gland	UBERON:0002046	47.11	silver quality
adult mammalian kidney	UBERON:0000082	46.75	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	45.30	silver quality
frontal cortex	UBERON:0001870	43.82	silver quality
heart	UBERON:0000948	42.41	silver quality
tibial artery	UBERON:0007610	42.04	silver quality
ascending aorta	UBERON:0001496	42.01	silver quality
amygdala	UBERON:0001876	42.01	silver quality
popliteal artery	UBERON:0002250	42.01	silver quality
thoracic aorta	UBERON:0001515	41.59	silver quality
right frontal lobe	UBERON:0002810	41.42	silver quality
Brodmann (1909) area 9	UBERON:0013540	41.31	silver quality
right atrium auricular region	UBERON:0006631	39.63	silver quality
left coronary artery	UBERON:0001626	38.90	silver quality
tibial nerve	UBERON:0001323	36.34	silver quality
skin of leg	UBERON:0001511	33.17	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• PCAT5 is a regulatory target for the transcription factor ERG, expressed in 50% of prostate cancers. PCAT5 is associated with castration-resistance prostate cancer. (PMID:26282172)
• Expression pattern of PCAT1, PCAT2, and PCAT5 lncRNAs and their value as diagnostic biomarkers in patients with gastric cancer. (PMID:37392552)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.