PCAT7

Summary

PCAT7 (prostate cancer associated transcript 7, HGNC:48824) is a long non-coding RNA gene on chromosome 9q22.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48824
Approved symbol	PCAT7
Name	prostate cancer associated transcript 7
Location	9q22.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	PCAN-R2
Ensembl gene	ENSG00000231806
Ensembl biotype	lncRNA
Entrez	101928099
RNAcentral	URS00026A19F7 — lncRNA, 4080 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000452148, ENST00000644721, ENST00000647389, ENST00000718017, ENST00000718018, ENST00000718019, ENST00000718020, ENST00000718021, ENST00000718022, ENST00000718149, ENST00000718150, ENST00000718151, ENST00000718152, ENST00000718153, ENST00000718154, ENST00000846118

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000452148 — 3 exons

Exon	Start	End
ENSE00001602795	94558969	94559152
ENSE00004033898	94567390	94568340
ENSE00004273601	94555034	94555310

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 84.99.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0360 / max 31.5205, expressed in 373 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
97462	0.9179	329
97461	0.1180	72

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.99	gold quality
secondary oocyte	CL:0000655	83.28	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.40	gold quality
hindlimb stylopod muscle	UBERON:0004252	79.33	gold quality
right lobe of liver	UBERON:0001114	76.33	gold quality
muscle of leg	UBERON:0001383	75.87	gold quality
gastrocnemius	UBERON:0001388	73.49	gold quality
colonic epithelium	UBERON:0000397	71.68	silver quality
body of stomach	UBERON:0001161	71.17	gold quality
stomach	UBERON:0000945	68.30	gold quality
fundus of stomach	UBERON:0001160	66.53	gold quality
mucosa of transverse colon	UBERON:0004991	65.15	gold quality
oocyte	CL:0000023	63.41	gold quality
liver	UBERON:0002107	63.40	gold quality
testis	UBERON:0000473	63.19	gold quality
left testis	UBERON:0004533	62.63	gold quality
right testis	UBERON:0004534	61.88	gold quality
body of pancreas	UBERON:0001150	60.89	gold quality
ventricular zone	UBERON:0003053	60.23	gold quality
duodenum	UBERON:0002114	59.86	gold quality
rectum	UBERON:0001052	58.89	gold quality
cortical plate	UBERON:0005343	58.88	gold quality
adult mammalian kidney	UBERON:0000082	58.81	gold quality
pancreas	UBERON:0001264	58.34	gold quality
transverse colon	UBERON:0001157	58.29	gold quality
ganglionic eminence	UBERON:0004023	56.87	silver quality
pons	UBERON:0000988	55.82	gold quality
right adrenal gland cortex	UBERON:0035827	55.73	gold quality
prefrontal cortex	UBERON:0000451	55.72	gold quality
skeletal muscle tissue	UBERON:0001134	55.69	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	688.65
E-ANND-3	yes	4.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• PCAT7 contributed to the progression of nasopharyngeal carcinoma through regulating miR-134-5p/ELF2 signaling pathway. (PMID:28728844)
• Overexpression of PCAT7 resulted in the promotion of tumor cell proliferation, inhibition of cells apoptosis, facilitation of cells metastasis, and formation of EMT phenotype, while PCAT7 expression deletion remarkably prohibited cell proliferation, accelerated their apoptosis, weakened metastasis, and reversed EMT to MET. (PMID:29275424)
• SMAD3/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-beta signaling promotes prostate cancer bone metastasis. (PMID:31925912)
• LncRNA PCAT6 promotes the proliferation, migration and invasion of pancreatic ductal adenocarcinoma via regulating miR-185-5p/CBX2 axis. (PMID:32825947)
• LncRNA PCAT7 promotes the malignant progression of breast cancer by regulating ErbB/PI3K/Akt pathway. (PMID:33401925)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.