PCBP1-AS1

Summary

PCBP1-AS1 (PCBP1 antisense RNA 1, HGNC:42948) is a long non-coding RNA gene on chromosome 2p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42948
Approved symbol	PCBP1-AS1
Name	PCBP1 antisense RNA 1
Location	2p13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	Linc-GALH
Ensembl gene	ENSG00000179818
Ensembl biotype	lncRNA
Entrez	400960
RNAcentral	URS000075CE39 — lncRNA, 2396 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 lncRNA, 1 retained_intron

ENST00000424748, ENST00000442326, ENST00000457870, ENST00000628659, ENST00000693139, ENST00000702462, ENST00000716044, ENST00000716045, ENST00000716046, ENST00000716047, ENST00000716048, ENST00000716049, ENST00000716050, ENST00000716051

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424748 — 2 exons

Exon	Start	End
ENSE00001691276	70093894	70094478
ENSE00001788541	70094959	70095166

Expression profiles

Bgee: expression breadth ubiquitous, 237 present calls, max score 97.05.

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.05	gold quality
lower esophagus mucosa	UBERON:0035834	96.93	gold quality
colonic epithelium	UBERON:0000397	96.60	gold quality
bone marrow cell	CL:0002092	96.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	96.31	gold quality
right lobe of liver	UBERON:0001114	95.05	gold quality
ganglionic eminence	UBERON:0004023	95.02	gold quality
adenohypophysis	UBERON:0002196	94.40	gold quality
calcaneal tendon	UBERON:0003701	94.33	gold quality
cortical plate	UBERON:0005343	94.04	gold quality
left ovary	UBERON:0002119	93.99	gold quality
right ovary	UBERON:0002118	93.50	gold quality
pituitary gland	UBERON:0000007	93.47	gold quality
right testis	UBERON:0004534	93.37	gold quality
left testis	UBERON:0004533	93.33	gold quality
cerebellar hemisphere	UBERON:0002245	93.09	gold quality
cerebellar cortex	UBERON:0002129	92.87	gold quality
body of uterus	UBERON:0009853	92.84	gold quality
body of pancreas	UBERON:0001150	92.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.55	gold quality
tibial nerve	UBERON:0001323	92.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.03	gold quality
endocervix	UBERON:0000458	91.96	gold quality
testis	UBERON:0000473	91.87	gold quality
ventricular zone	UBERON:0003053	91.80	gold quality
islet of Langerhans	UBERON:0000006	91.79	gold quality
ectocervix	UBERON:0012249	91.77	gold quality
cerebellum	UBERON:0002037	91.75	gold quality
adrenal tissue	UBERON:0018303	91.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.57	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	48.79
E-ANND-3	yes	5.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LncRNA PCBP1-AS1 correlated with the functional states of cancer cells and inhibited lung adenocarcinoma metastasis by suppressing the EMT progression. (PMID:34107009)
• lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma. (PMID:37256932)
• LncRNA PCBP1-AS1 Induces Cerebral Ischemia/Reperfusion Injury via the miR-506-3p/CCL2 Axis. (PMID:37437927)
• Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review. (PMID:37904442)
• A small protein encoded by PCBP1-AS1 is identified as a key regulator of influenza virus replication via enhancing autophagy. (PMID:39137200)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.