PCBP2-OT1

Summary

PCBP2-OT1 (PCBP2 overlapping transcript 1, HGNC:49150) is a long non-coding RNA gene on chromosome 12q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49150
Approved symbol	PCBP2-OT1
Name	PCBP2 overlapping transcript 1
Location	12q13.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	TUC338, uc.338, TUC.338
Ensembl gene	ENSG00000282977
Ensembl biotype	lncRNA
Entrez	102157401
RNAcentral	URS0000594F47 — lncRNA, 590 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000634357

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000634357 — 1 exons

Exon	Start	End
ENSE00003784645	53464468	53465057

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 82.91.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.91	gold quality
bone marrow	UBERON:0002371	82.76	gold quality
bone marrow cell	CL:0002092	82.11	gold quality
sural nerve	UBERON:0015488	79.23	gold quality
colonic epithelium	UBERON:0000397	77.93	gold quality
skeletal muscle tissue	UBERON:0001134	72.89	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.07	gold quality
tonsil	UBERON:0002372	70.27	gold quality
ganglionic eminence	UBERON:0004023	69.22	gold quality
uterine cervix	UBERON:0000002	68.94	gold quality
ventricular zone	UBERON:0003053	68.58	gold quality
skin of leg	UBERON:0001511	68.52	gold quality
tibial nerve	UBERON:0001323	68.25	gold quality
zone of skin	UBERON:0000014	68.22	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.75	gold quality
skin of abdomen	UBERON:0001416	67.69	gold quality
left ovary	UBERON:0002119	67.63	gold quality
ovary	UBERON:0000992	67.47	gold quality
right ovary	UBERON:0002118	67.28	gold quality
cortical plate	UBERON:0005343	67.26	gold quality
cerebellum	UBERON:0002037	67.18	gold quality
cerebellar cortex	UBERON:0002129	67.03	gold quality
adrenal tissue	UBERON:0018303	67.02	gold quality
cerebellar hemisphere	UBERON:0002245	66.97	gold quality
urinary bladder	UBERON:0001255	66.64	gold quality
popliteal artery	UBERON:0002250	66.36	gold quality
tibial artery	UBERON:0007610	66.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.27	gold quality
blood	UBERON:0000178	66.01	gold quality
mucosa of stomach	UBERON:0001199	65.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• overexpression leads to enhanced proliferation and reduced apoptosis in tongue squamous cell carcinoma (PMID:27637778)
• TUC338 role in in sorafenib-resistance of liver cancer cells (PMID:27878301)
• TUC.338 is up-regulated in colorectal cancer tissues and cell lines, and it is associated with lymphatic metastasis.TIMP-1 is negatively regulated by TUC.338 at the posttranscriptional level, via a specific target site within the 3’ UTR. TUC.338 acts as a novel oncogene by targeting the TIMP-1 gene thus promoting colorectal cancer cell migration and invasion. (PMID:27914101)
• After interfering and overexpressing TUC338, it was found that the activity of lung cancer cells was decreased, as well as the invasion ability after interference with TUC338. (PMID:29424901)
• Our results show that uc.338 may play an important role in tumorigenesis and progression and could serve as a potential independent prognostic biomarker for patients with non-small cell lung cancer (PMID:29843223)
• Results found that TUC338 was upregulated in tumor tissues of prostate carcinoma patients as well as its plasma levels which correlates with poor survival. Further results provide evidence that TUC338 may serve as an oncogene in prostate carcinoma patients by downregulating miR-466. (PMID:31085276)
• lncRNA TUC338 is a potential diagnostic biomarker for bladder cancer. (PMID:31162712)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.