PCBP3

Summary

PCBP3 (poly(rC) binding protein 3, HGNC:8651) is a protein-coding gene on chromosome 21q22.3, encoding Poly(rC)-binding protein 3 (P57721). Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Source: NCBI Gene 54039 — RefSeq curated summary.

At a glance

• GWAS associations: 15
• Clinical variants (ClinVar): 61 total — 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001384156

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8651
Approved symbol	PCBP3
Name	poly(rC) binding protein 3
Location	21q22.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ44028
Ensembl gene	ENSG00000183570
Ensembl biotype	protein_coding
OMIM	608502
Entrez	54039

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 20 protein_coding, 11 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000400304, ENST00000400305, ENST00000400308, ENST00000400309, ENST00000400310, ENST00000400314, ENST00000423045, ENST00000449640, ENST00000465077, ENST00000468429, ENST00000472191, ENST00000475402, ENST00000481302, ENST00000498121, ENST00000549265, ENST00000593338, ENST00000594149, ENST00000594320, ENST00000609985, ENST00000610200, ENST00000628776, ENST00000681687, ENST00000909830, ENST00000909831, ENST00000909832, ENST00000909833, ENST00000909834, ENST00000922168, ENST00000922169, ENST00000965783, ENST00000965784, ENST00000965785, ENST00000965786

RefSeq mRNA: 23 — MANE Select: NM_001384156 NM_001130141, NM_001348238, NM_001348239, NM_001348240, NM_001348241, NM_001348242, NM_001348243, NM_001348244, NM_001348245, NM_001382276, NM_001382277, NM_001382278, NM_001382279, NM_001382281, NM_001382282, NM_001382283, NM_001382284, NM_001382285, NM_001382286, NM_001382287, NM_001382288, NM_001384156, NM_020528

CCDS: CCDS42974, CCDS46652, CCDS86993, CCDS86994

Canonical transcript exons

ENST00000681687 — 18 exons

Exon	Start	End
ENSE00001299723	45900997	45901113
ENSE00001322404	45929917	45929995
ENSE00001542369	45735392	45735429
ENSE00002301087	45849961	45850095
ENSE00003472505	45917588	45917629
ENSE00003535780	45900591	45900623
ENSE00003585868	45909355	45909486
ENSE00003588949	45930786	45930845
ENSE00003604223	45935253	45935305
ENSE00003605727	45910902	45911030
ENSE00003635207	45940030	45940199
ENSE00003637603	45913951	45914025
ENSE00003639940	45899599	45899622
ENSE00003745442	45896208	45896362
ENSE00003911389	45755417	45755452
ENSE00003912086	45668874	45668952
ENSE00003915400	45643725	45643868
ENSE00003915807	45941670	45942450

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 95.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.4585 / max 334.6234, expressed in 1285 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189580	9.1793	1237
189577	0.4002	229
189579	0.3894	180
189576	0.2711	134
189578	0.1888	63
189583	0.0160	4
189584	0.0138	4

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.77	gold quality
cerebellar hemisphere	UBERON:0002245	95.76	gold quality
cerebellar cortex	UBERON:0002129	95.57	gold quality
cerebellum	UBERON:0002037	92.36	gold quality
adenohypophysis	UBERON:0002196	89.59	gold quality
right testis	UBERON:0004534	89.02	gold quality
left testis	UBERON:0004533	88.79	gold quality
pituitary gland	UBERON:0000007	86.34	gold quality
testis	UBERON:0000473	85.09	gold quality
mucosa of stomach	UBERON:0001199	84.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	83.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	82.46	gold quality
lower esophagus	UBERON:0013473	82.33	gold quality
right frontal lobe	UBERON:0002810	82.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.45	gold quality
cingulate cortex	UBERON:0003027	80.17	gold quality
anterior cingulate cortex	UBERON:0009835	80.03	gold quality
body of uterus	UBERON:0009853	79.88	gold quality
spleen	UBERON:0002106	79.52	gold quality
prefrontal cortex	UBERON:0000451	79.45	gold quality
spinal cord	UBERON:0002240	79.41	gold quality
nucleus accumbens	UBERON:0001882	78.16	gold quality
omental fat pad	UBERON:0010414	77.86	gold quality
sural nerve	UBERON:0015488	77.82	gold quality
peritoneum	UBERON:0002358	77.76	gold quality
left uterine tube	UBERON:0001303	77.62	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.60	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	6.76
E-ANND-3	no	4.79

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HNRNPK, TFCP2

miRNA regulators (miRDB)

22 targeting PCBP3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-7-5P	99.67	70.53	1809
HSA-MIR-2053	99.57	69.15	1635
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-4677-3P	99.49	67.91	1246
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-6808-5P	99.31	66.23	2150
HSA-MIR-6893-5P	99.31	66.25	2119
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-4763-3P	99.10	67.83	2649
HSA-MIR-760	98.81	66.65	1392
HSA-MIR-423-5P	98.69	67.48	1522
HSA-MIR-3184-5P	98.56	67.13	1491
HSA-MIR-4675	97.69	64.82	774
HSA-MIR-4741	97.69	64.14	883
HSA-MIR-4723-3P	97.67	65.91	1017
HSA-MIR-6769B-3P	97.41	65.53	1036
HSA-MIR-3183	97.40	65.68	978
HSA-MIR-6800-3P	96.15	65.16	461
HSA-MIR-3141	84.79	60.38	35

Literature-anchored findings (GeneRIF, showing 3)

• Study examined splicing factors located on chromosome 21 for their effect on tau exon 10 and discovered that one of them, hnRNPE3 (PCBP3), modestly activates splicing of exon 10 by interacting with its proximal downstream intron around position +19. (PMID:19914360)
• Low PCBP3 expression is associated with Pancreatic ductal adenocarcinoma. (PMID:30275197)
• LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3. (PMID:35920801)

Cross-species orthologs

13 orthologs

Organism	Symbol	Gene ID
danio_rerio	zgc:110045	ENSDARG00000057141
mus_musculus	Pcbp3	ENSMUSG00000001120
rattus_norvegicus	Pcbp3	ENSRNOG00000001245
drosophila_melanogaster	Psi	FBGN0014870
drosophila_melanogaster	ps	FBGN0261552
drosophila_melanogaster	mub	FBGN0262737
drosophila_melanogaster	Imp	FBGN0285926
caenorhabditis_elegans		WBGENE00003978
caenorhabditis_elegans		WBGENE00007534
caenorhabditis_elegans		WBGENE00010908
caenorhabditis_elegans		WBGENE00013347
caenorhabditis_elegans		WBGENE00016489
caenorhabditis_elegans	fubl-4	WBGENE00019692

Paralogs (12): IGF2BP2 (ENSG00000073792), KHSRP (ENSG00000088247), PCBP4 (ENSG00000090097), NOVA2 (ENSG00000104967), FUBP3 (ENSG00000107164), IGF2BP3 (ENSG00000136231), NOVA1 (ENSG00000139910), IGF2BP1 (ENSG00000159217), FUBP1 (ENSG00000162613), HNRNPK (ENSG00000165119), PCBP1 (ENSG00000169564), PCBP2 (ENSG00000197111)

Protein

Protein identifiers

Poly(rC)-binding protein 3 — P57721 (reviewed: P57721)

Alternative names: Alpha-CP3, PCBP3-overlapping transcript, PCBP3-overlapping transcript 1

All UniProt accessions (3): E9PFP8, P57721, J3QT27

UniProt curated annotations — full annotation on UniProt →

Function. Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Subcellular location. Cytoplasm.

Isoforms (5)

UniProt ID	Names	Canonical?
P57721-1	1	yes
P57721-2	2
P57721-3	3
P57721-4	4
P57721-5	5

RefSeq proteins (23): NP_001123613, NP_001335167, NP_001335168, NP_001335169, NP_001335170, NP_001335171, NP_001335172, NP_001335173, NP_001335174, NP_001369205, NP_001369206, NP_001369207, NP_001369208, NP_001369210, NP_001369211, NP_001369212, NP_001369213, NP_001369214, NP_001369215, NP_001369216, NP_001369217, NP_001371085, NP_065389 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004087	KH_dom	Domain
IPR004088	KH_dom_type_1	Domain
IPR036612	KH_dom_type_1_sf	Homologous_superfamily

Pfam: PF00013

UniProt features (7 total): domain 3, splice variant 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P57721-F1	67.29	0.02

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): MORF_RAGE, CAR_TNFRSF25, MORF_FANCG, CAR_MYST2, GOBP_VIRAL_GENOME_REPLICATION, GOBP_VIRAL_LIFE_CYCLE, CAR_MLANA, MORF_PML, MORF_PDPK1, MORF_IKBKG, chr21q22, MORF_MT4, GOMF_SINGLE_STRANDED_DNA_BINDING, MORF_ORC1L, MORF_RFC1

GO Biological Process (4): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), mRNA metabolic process (GO:0016071), viral RNA genome replication (GO:0039694)

GO Molecular Function (6): RNA binding (GO:0003723), mRNA binding (GO:0003729), C-rich single-stranded DNA binding (GO:1990829), nucleic acid binding (GO:0003676), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), extracellular exosome (GO:0070062), ribonucleoprotein complex (GO:1990904)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	2
nucleic acid binding	2
binding	2
cellular anatomical structure	2
regulation of transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
RNA metabolic process	1
viral genome replication	1
RNA biosynthetic process	1
RNA binding	1
single-stranded DNA binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
extracellular vesicle	1
protein-containing complex	1

Protein interactions and networks

STRING

1134 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PCBP3	YBEY	P58557	610
PCBP3	POFUT2	Q9Y2G5	558
PCBP3	RBM11	P57052	473
PCBP3	RWDD2B	P57060	437
PCBP3	COMMD9	Q9P000	433
PCBP3	TRIB3	Q96RU7	416
PCBP3	TRMT11	Q7Z4G4	400
PCBP3	PROP1	O75360	389
PCBP3	ART1	P52961	387
PCBP3	GEMIN5	Q8TEQ6	387
PCBP3	WDR7	Q9Y4E6	384
PCBP3	HNRNPDL	O14979	379
PCBP3	DIRAS1	O95057	377
PCBP3	SLC19A1	P41440	376
PCBP3	ZNF827	Q17R98	374

IntAct

81 interactions, top by confidence:

A	B	Type	Score
PSMA5	PSMA7	psi-mi:“MI:0914”(association)	0.800
COPRS	PRMT5	psi-mi:“MI:0914”(association)	0.770
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
ENO2	ENO1	psi-mi:“MI:0914”(association)	0.710
EIF4EBP1	EIF4E1B	psi-mi:“MI:0914”(association)	0.670
EIF3E	EIF3F	psi-mi:“MI:0914”(association)	0.640
GNPDA2	GNPDA1	psi-mi:“MI:0914”(association)	0.640
MSRB2	BLTP3B	psi-mi:“MI:0914”(association)	0.530
KCTD17	CBX4	psi-mi:“MI:0914”(association)	0.530
CCDC6	LZTS3	psi-mi:“MI:0914”(association)	0.530
PDCD2L	PRMT3	psi-mi:“MI:0914”(association)	0.530
WNT16	WNT11	psi-mi:“MI:0914”(association)	0.530
COLGALT2	COL1A1	psi-mi:“MI:0914”(association)	0.530
PLOD3	COL4A1	psi-mi:“MI:0914”(association)	0.530
BBOX1	ITPRID2	psi-mi:“MI:0914”(association)	0.530
PSMA2	PSMD11	psi-mi:“MI:0914”(association)	0.530
RAB6B	RAB6A	psi-mi:“MI:0914”(association)	0.530
Aif1l		psi-mi:“MI:0915”(physical association)	0.400
RTL8B	PCBP3	psi-mi:“MI:0915”(physical association)	0.400
GFUS	PCBP3	psi-mi:“MI:0915”(physical association)	0.400
TRMT5	PCBP3	psi-mi:“MI:0915”(physical association)	0.400
GCLM	PCBP3	psi-mi:“MI:0915”(physical association)	0.400
AGXT	PCBP3	psi-mi:“MI:0915”(physical association)	0.400
LGALSL	PCBP3	psi-mi:“MI:0915”(physical association)	0.400
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (185): PCBP3 (Affinity Capture-Western), PCBP1 (Affinity Capture-Western), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Proximity Label-MS), PCBP3 (Proximity Label-MS), PCBP3 (Affinity Capture-MS), PCBP3 (Affinity Capture-MS)

ESM2 similar proteins: A0A8I6G705, A1L3K1, B5DFF2, B5DFI8, G3MWR8, O19048, O19137, O88508, P06730, P29338, P57721, P57722, P60335, Q12800, Q13888, Q15365, Q15366, Q16763, Q1LZ53, Q1RML1, Q28D01, Q2TBV5, Q4W5Z4, Q5E9A3, Q5FVR7, Q5NVP9, Q5TDH0, Q61990, Q6AYU1, Q6DH13, Q6P1K8, Q6ZRY4, Q7RTP6, Q8C6G8, Q8CCI5, Q8CJ19, Q8IY57, Q8N488, Q8VC52, Q921J4

Diamond homologs: A0A0B4KGY6, A0A1W2P872, O19048, O19049, O73932, O74919, P51513, P57721, P57722, P60335, P61978, P61979, P61980, Q15365, Q15366, Q2PFW9, Q32PX7, Q3T0D0, Q4R4M6, Q5E9A3, Q5R5H8, Q5RB68, Q5SF07, Q5ZIQ3, Q5ZLP8, Q61990, Q80WA4, Q8UVD9, Q91WJ8, Q96AE4, Q96I24, Q9JKN6, Q9LZ82, Q9SZH4, Q9UNW9, Q9Y6M1, O00425, P38151, P57723, P57724

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 118 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Glycolysis	5	16.2×	9e-04
Regulation of RUNX3 expression and activity	6	15.9×	8e-04
Regulation of activated PAK-2p34 by proteasome mediated degradation	5	15.8×	9e-04
Regulation of ornithine decarboxylase (ODC)	5	15.4×	9e-04
Vpu mediated degradation of CD4	5	15.1×	9e-04
Autodegradation of the E3 ubiquitin ligase COP1	5	15.1×	9e-04
Ubiquitin-dependent degradation of Cyclin D	5	15.1×	9e-04
Defective CFTR causes cystic fibrosis	6	15.0×	8e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	42
Likely benign	6
Benign	4

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
394602	GRCh37/hg19 21q22.3(chr21:46955240-48080867)x1	Likely pathogenic

SpliceAI

8074 predictions. Top by Δscore:

Variant	Effect	Δscore
21:45643867:AGGT:A	donor_loss	1.0000
21:45643868:GGT:G	donor_loss	1.0000
21:45643869:GT:G	donor_loss	1.0000
21:45735380:AACT:A	acceptor_gain	1.0000
21:45735428:GT:G	donor_gain	1.0000
21:45735430:G:GG	donor_gain	1.0000
21:45899619:GAAGG:G	donor_loss	1.0000
21:45899623:G:GA	donor_loss	1.0000
21:45899624:T:G	donor_loss	1.0000
21:45900996:GA:G	acceptor_gain	1.0000
21:45901111:G:GT	donor_gain	1.0000
21:45911028:G:GT	donor_gain	1.0000
21:45911104:G:GT	donor_gain	1.0000
21:45643864:GGCAG:G	donor_gain	0.9900
21:45643865:GCAG:G	donor_gain	0.9900
21:45643865:GCAGG:G	donor_gain	0.9900
21:45643869:G:GG	donor_gain	0.9900
21:45649688:T:TA	acceptor_gain	0.9900
21:45735380:A:AG	acceptor_gain	0.9900
21:45735381:A:G	acceptor_gain	0.9900
21:45735383:T:A	acceptor_gain	0.9900
21:45735386:TTACA:T	acceptor_loss	0.9900
21:45735387:TACAG:T	acceptor_loss	0.9900
21:45735389:CA:C	acceptor_loss	0.9900
21:45735390:A:AT	acceptor_loss	0.9900
21:45735391:G:GT	acceptor_loss	0.9900
21:45735428:GTGTA:G	donor_loss	0.9900
21:45735430:G:GA	donor_loss	0.9900
21:45735431:T:TT	donor_loss	0.9900
21:45735432:A:AT	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000000905 (21:45884320 G>C), RS1000042485 (21:45923762 A>C,G), RS1000050760 (21:45721324 A>G), RS1000053826 (21:45892447 G>A), RS1000073459 (21:45780610 A>G), RS1000082110 (21:45862033 A>G,T), RS1000094531 (21:45695647 A>C), RS1000107756 (21:45902652 C>A), RS1000108670 (21:45726972 G>C), RS1000108993 (21:45770598 A>G), RS1000120266 (21:45748348 G>A,T), RS1000134741 (21:45789353 C>T), RS1000137666 (21:45853997 A>G), RS1000154893 (21:45848663 A>C), RS1000167375 (21:45778181 G>T)

Disease associations

OMIM: gene MIM:608502 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

15 associations (top):

Study	Trait	p-value
GCST001208_10	Insulin resistance/response	1.000000e-06
GCST003997_8	Myopia	5.000000e-13
GCST004952_39	Ankle injury	4.000000e-08
GCST005580_40	Intraocular pressure	5.000000e-13
GCST006291_125	Spherical equivalent or myopia (age of diagnosis)	1.000000e-14
GCST006976_96	Macular thickness	9.000000e-09
GCST007637_14	Diffusing capacity of carbon monoxide	2.000000e-06
GCST009306_19	Spatial processing	9.000000e-06
GCST010002_78	Refractive error	2.000000e-36
GCST011494_105	Daytime nap	4.000000e-11
GCST012402_14	Low myopia	3.000000e-06
GCST90013442_35	Keratoconus	9.000000e-12
GCST90020024_818	A body shape index	1.000000e-08
GCST90020029_163	Waist circumference adjusted for body mass index	4.000000e-10
GCST90020029_164	Waist circumference adjusted for body mass index	3.000000e-08

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:1002021	ankle injury
EFO:0004695	intraocular pressure measurement
EFO:0004847	age at onset
EFO:0009369	diffusing capacity of the lung for carbon monoxide
EFO:0008354	cognitive function measurement
EFO:0007828	daytime rest measurement
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5465293 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, decreases methylation, increases expression	3
(+)-JQ1 compound	increases expression	2
Benzo(a)pyrene	affects methylation, decreases expression, decreases methylation	2
Valproic Acid	affects expression, decreases methylation	2
triphenyl phosphate	affects expression	1
N-(1-naphthyl)ethylenediamine	affects response to substance	1
trichostatin A	affects expression	1
sodium arsenite	affects methylation	1
aflatoxin B2	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
jinfukang	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Phthalic Acids	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Progesterone	increases expression	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1
Smoke	increases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Tobacco Smoke Pollution	decreases methylation	1
Tretinoin	decreases expression	1
Aflatoxin B1	affects methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5338437	Binding	Binding affinity to Pcbp3 (unknown origin) at 200 uM preincubated for 2 hrs followed by pronase addition and measured after 30 mins by coomassie blue staining based SDS-PAGE gel analysis	Structurally Diverse Alkaloids with Anti-Renal-Fibrosis Activity from the Centipede Scolopendra subspinipes mutilans. — J Nat Prod

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.