PCBP4

Summary

PCBP4 (poly(rC) binding protein 4, HGNC:8652) is a protein-coding gene on chromosome 3p21.2, encoding Poly(rC)-binding protein 4 (P57723). Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene’s protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.

Source: NCBI Gene 57060 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 70 total
• MANE Select transcript: NM_001174100

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8652
Approved symbol	PCBP4
Name	poly(rC) binding protein 4
Location	3p21.2
Locus type	gene with protein product
Status	Approved
Aliases	MCG10, LIP4
Ensembl gene	ENSG00000090097
Ensembl biotype	protein_coding
OMIM	608503
Entrez	57060

Gene structure

Transcript identifiers

Ensembl transcripts: 97 — 92 protein_coding, 4 retained_intron, 1 nonsense_mediated_decay

ENST00000322099, ENST00000355852, ENST00000428823, ENST00000461544, ENST00000461554, ENST00000466412, ENST00000468324, ENST00000471308, ENST00000471358, ENST00000471622, ENST00000483411, ENST00000484633, ENST00000489595, ENST00000490063, ENST00000492809, ENST00000497390, ENST00000497653, ENST00000498822, ENST00000893872, ENST00000893873, ENST00000893874, ENST00000893875, ENST00000893876, ENST00000893877, ENST00000893878, ENST00000893879, ENST00000893880, ENST00000893881, ENST00000893882, ENST00000893883, ENST00000893884, ENST00000893885, ENST00000893886, ENST00000893887, ENST00000893888, ENST00000893889, ENST00000893890, ENST00000893891, ENST00000893892, ENST00000893893, ENST00000893894, ENST00000913102, ENST00000913103, ENST00000913104, ENST00000913105, ENST00000913106, ENST00000913107, ENST00000913108, ENST00000913109, ENST00000913110, ENST00000913111, ENST00000913112, ENST00000913113, ENST00000913114, ENST00000913115, ENST00000913116, ENST00000913117, ENST00000913118, ENST00000913119, ENST00000913120, ENST00000952276, ENST00000952277, ENST00000952278, ENST00000952279, ENST00000952280, ENST00000952281, ENST00000952282, ENST00000952283, ENST00000952284, ENST00000952285, ENST00000952286, ENST00000952287, ENST00000952288, ENST00000952289, ENST00000952290, ENST00000952291, ENST00000952292, ENST00000952293, ENST00000952294, ENST00000952295, ENST00000952296, ENST00000952297, ENST00000952298, ENST00000952299, ENST00000952300, ENST00000952301, ENST00000952302, ENST00000952303, ENST00000952304, ENST00000952305, ENST00000952306, ENST00000952307, ENST00000952308, ENST00000952309, ENST00000952310, ENST00000952311, ENST00000952312

RefSeq mRNA: 5 — MANE Select: NM_001174100 NM_001174100, NM_001363885, NM_020418, NM_033008, NM_033010

CCDS: CCDS2839, CCDS2840, CCDS87085

Canonical transcript exons

ENST00000461554 — 14 exons

Exon	Start	End
ENSE00001938324	51967326	51967454
ENSE00003477655	51959047	51959099
ENSE00003498446	51959577	51959651
ENSE00003506962	51960189	51960320
ENSE00003628562	51959229	51959292
ENSE00003649262	51959367	51959411
ENSE00003655438	51957458	51958349
ENSE00003677254	51959895	51960023
ENSE00003683411	51958790	51958959
ENSE00003708437	51961941	51962088
ENSE00003780770	51961010	51961033
ENSE00003781813	51961160	51961304
ENSE00003781983	51960526	51960642
ENSE00003785480	51960866	51960898

Expression profiles

Bgee: expression breadth ubiquitous, 273 present calls, max score 99.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.6100 / max 1314.0799, expressed in 1544 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
42389	46.2963	1817
42379	22.1146	1509
42378	3.4896	1137
42377	1.6051	718
42381	0.5999	294
42383	0.4900	58
42384	0.4881	160
42382	0.4646	209
42376	0.1952	86
42385	0.1101	71

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	99.25	gold quality
cerebellar hemisphere	UBERON:0002245	99.18	gold quality
cerebellar cortex	UBERON:0002129	99.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.35	gold quality
tibial nerve	UBERON:0001323	98.21	gold quality
cerebellum	UBERON:0002037	98.20	gold quality
sural nerve	UBERON:0015488	98.11	gold quality
spinal cord	UBERON:0002240	97.74	gold quality
right frontal lobe	UBERON:0002810	97.31	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.30	gold quality
gastrocnemius	UBERON:0001388	97.19	gold quality
ganglionic eminence	UBERON:0004023	96.81	gold quality
muscle of leg	UBERON:0001383	96.57	gold quality
apex of heart	UBERON:0002098	96.48	gold quality
amygdala	UBERON:0001876	96.38	gold quality
cortical plate	UBERON:0005343	96.20	gold quality
hypothalamus	UBERON:0001898	96.06	gold quality
right atrium auricular region	UBERON:0006631	95.75	gold quality
inferior vagus X ganglion	UBERON:0005363	95.73	gold quality
cingulate cortex	UBERON:0003027	95.69	gold quality
anterior cingulate cortex	UBERON:0009835	95.62	gold quality
Brodmann (1909) area 9	UBERON:0013540	95.49	gold quality
inferior olivary complex	UBERON:0002127	95.11	gold quality
ascending aorta	UBERON:0001496	94.95	gold quality
putamen	UBERON:0001874	94.93	gold quality
thoracic aorta	UBERON:0001515	94.90	gold quality
olfactory bulb	UBERON:0002264	94.89	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	94.63	gold quality
descending thoracic aorta	UBERON:0002345	94.50	gold quality
subthalamic nucleus	UBERON:0001906	94.49	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-HCAD-5	yes	872.19
E-HCAD-56	yes	856.68
E-GEOD-93593	yes	732.18
E-MTAB-6108	yes	621.13
E-GEOD-137537	yes	13.09
E-MTAB-11121	no	946.22
E-MTAB-7316	no	29.29
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

60 targeting PCBP4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-2116-3P	99.74	64.32	889
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-10394-5P	99.65	66.83	1852
HSA-MIR-1205	99.65	66.76	1826
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-671-5P	99.52	67.11	1277
HSA-MIR-548G-3P	99.48	68.67	2159
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-4797-5P	99.39	68.01	1354
HSA-MIR-532-3P	99.34	65.76	1195

Literature-anchored findings (GeneRIF, showing 2)

• expression of alpha CP-4 can inhibit proliferation and tumorigenesis of lung cancer cells, both in vivo and in vitro, by delaying the progression of the cell cycle (PMID:17973258)
• PCBP4 plays important roles in the induction of cisplatin resistance in human maxillary cancers. (PMID:26196957)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	pcbp4	ENSDARG00000024276
mus_musculus	Pcbp4	ENSMUSG00000023495
rattus_norvegicus	Pcbp4	ENSRNOG00000012406
drosophila_melanogaster	ps	FBGN0261552
drosophila_melanogaster	mub	FBGN0262737
drosophila_melanogaster	Imp	FBGN0285926
caenorhabditis_elegans		WBGENE00003978
caenorhabditis_elegans		WBGENE00010908
caenorhabditis_elegans		WBGENE00013347
caenorhabditis_elegans		WBGENE00016489
caenorhabditis_elegans	fubl-4	WBGENE00019692

Paralogs (12): IGF2BP2 (ENSG00000073792), KHSRP (ENSG00000088247), NOVA2 (ENSG00000104967), FUBP3 (ENSG00000107164), IGF2BP3 (ENSG00000136231), NOVA1 (ENSG00000139910), IGF2BP1 (ENSG00000159217), FUBP1 (ENSG00000162613), HNRNPK (ENSG00000165119), PCBP1 (ENSG00000169564), PCBP3 (ENSG00000183570), PCBP2 (ENSG00000197111)

Protein

Protein identifiers

Poly(rC)-binding protein 4 — P57723 (reviewed: P57723)

Alternative names: Alpha-CP4

All UniProt accessions (10): P57723, C9IZV9, C9J0A4, C9J5V4, C9J7A9, C9JSA6, C9JTY5, C9JZY3, C9K0A2, F8WC71

UniProt curated annotations — full annotation on UniProt →

Function. Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.

Subcellular location. Cytoplasm.

Isoforms (2)

UniProt ID	Names	Canonical?
P57723-1	1	yes
P57723-2	2

RefSeq proteins (5): NP_001167571, NP_001350814, NP_065151, NP_127501, NP_127503 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004087	KH_dom	Domain
IPR004088	KH_dom_type_1	Domain
IPR036612	KH_dom_type_1_sf	Homologous_superfamily

Pfam: PF00013

UniProt features (6 total): domain 3, chain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P57723-F1	67.18	0.08

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-69895	Transcriptional activation of cell cycle inhibitor p21
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes

MSigDB gene sets: 231 (showing top): RNGTGGGC_UNKNOWN, CREL_01, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GCANCTGNY_MYOD_Q6, GOBP_NEGATIVE_REGULATION_OF_RNA_SPLICING, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, TGACCTY_ERR1_Q2, GGGTGGRR_PAX4_03, CAGCTG_AP4_Q5, YY1_Q6, NFKB_Q6, MODULE_66, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION

GO Biological Process (5): regulation of transcription by RNA polymerase II (GO:0006357), regulation of mRNA stability (GO:0043488), negative regulation of mRNA splicing, via spliceosome (GO:0048025), regulation of gene expression (GO:0010468), regulation of mRNA metabolic process (GO:1903311)

GO Molecular Function (6): DNA binding (GO:0003677), RNA binding (GO:0003723), mRNA binding (GO:0003729), mRNA 3’-UTR binding (GO:0003730), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
TP53 Regulates Transcription of Cell Cycle Genes	1
Transcriptional activation of p53 responsive genes	1
FOXO-mediated transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nucleic acid binding	2
binding	2
cellular anatomical structure	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
regulation of RNA stability	1
regulation of mRNA catabolic process	1
mRNA splicing, via spliceosome	1
negative regulation of RNA splicing	1
regulation of mRNA splicing, via spliceosome	1
negative regulation of mRNA processing	1
gene expression	1
regulation of macromolecule biosynthetic process	1
mRNA metabolic process	1
regulation of RNA metabolic process	1
RNA binding	1
mRNA binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
protein-containing complex	1

Protein interactions and networks

STRING

1011 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PCBP4	TP53	P04637	653
PCBP4	ZNF521	Q96K83	620
PCBP4	VTA1	Q9NP79	545
PCBP4	DNAJC14	Q6Y2X3	526
PCBP4	RBM38	Q9H0Z9	461
PCBP4	RBFOX2	O43251	454
PCBP4	HNRNPDL	O14979	444
PCBP4	MBNL2	Q5VZF2	418
PCBP4	ULK3	Q6PHR2	415
PCBP4	ZNF709	Q8N972	407
PCBP4	MBNL1	Q9NR56	400
PCBP4	CNTROB	Q8N137	392
PCBP4	IP6K3	Q96PC2	388
PCBP4	RBM8A	Q9Y5S9	377
PCBP4	SAMD7	Q7Z3H4	364

IntAct

25 interactions, top by confidence:

A	B	Type	Score
PCBP4	HSPA8	psi-mi:“MI:0915”(physical association)	0.560
MRPS18C	MRPS14	psi-mi:“MI:0914”(association)	0.530
MIEN1	PCBP4	psi-mi:“MI:0915”(physical association)	0.400
PPDPFL	PCBP4	psi-mi:“MI:0915”(physical association)	0.400
MRPL53		psi-mi:“MI:0914”(association)	0.350
ZNF664	GAPDHS	psi-mi:“MI:0914”(association)	0.350
PHF5A	VPS26C	psi-mi:“MI:0914”(association)	0.350
TMEM126A	IPO7	psi-mi:“MI:0914”(association)	0.350
GTF2A2	S100P	psi-mi:“MI:0914”(association)	0.350
TXNDC8	S100P	psi-mi:“MI:0914”(association)	0.350
ABCB9	PIK3CA	psi-mi:“MI:0914”(association)	0.350
SSR3	HMGCS2	psi-mi:“MI:0914”(association)	0.350
SPMIP9	PCBP4	psi-mi:“MI:0914”(association)	0.350
PCBP4	PPID	psi-mi:“MI:0914”(association)	0.350
PCBP4	TUSC2	psi-mi:“MI:0914”(association)	0.350
AFG2A	ESYT2	psi-mi:“MI:0914”(association)	0.350
AFG2B	MMP24OS	psi-mi:“MI:0914”(association)	0.350
INSR	ATOX1	psi-mi:“MI:0914”(association)	0.350
INSR	RIMOC1	psi-mi:“MI:0914”(association)	0.350
RBFOX1	PCBP4	psi-mi:“MI:0915”(physical association)	0.000
PCBP1	PCBP4	psi-mi:“MI:0915”(physical association)	0.000
QKI	PCBP4	psi-mi:“MI:0915”(physical association)	0.000
RNF138	PCBP4	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (55): PCBP1 (Affinity Capture-Western), PCBP4 (Affinity Capture-MS), PPID (Affinity Capture-MS), TRIM11 (Affinity Capture-MS), CSPG4 (Affinity Capture-MS), PPID (Affinity Capture-MS), TRIM11 (Affinity Capture-MS), CSPG4 (Affinity Capture-MS), PCBP4 (Affinity Capture-MS), DYNC1LI2 (Affinity Capture-MS), PCBP4 (Affinity Capture-MS), PCBP4 (Affinity Capture-MS), PCBP4 (Affinity Capture-MS), PCBP4 (Protein-RNA), PCBP4 (Proximity Label-MS)

ESM2 similar proteins: A0A1W2P872, A1L1C7, A4IIM2, B2RYD2, F1LQ48, O57406, O88532, O95319, P14866, P28659, P51513, P57723, P57724, Q28HE9, Q2PFW9, Q32PX7, Q3U0V1, Q3US41, Q4QQT3, Q4R535, Q58A45, Q5F3T7, Q5NVC8, Q5R8Y8, Q5R995, Q5U231, Q640Q5, Q6DGV1, Q6GPM1, Q6NXG1, Q6P0B1, Q6PF35, Q792H5, Q7T2T1, Q7TSY6, Q7ZXE2, Q80WA4, Q8R081, Q8UVD9, Q91WJ8

Diamond homologs: A0A0B4KGY6, A0A1W2P872, O00425, O19048, P38151, P51513, P57721, P57722, P57723, P57724, P60335, Q0VCU0, Q15365, Q15366, Q21920, Q2PFW9, Q5E9A3, Q5ZLP8, Q61990, Q80WA4, Q9CPN8, Q9JKN6, Q9SR13, Q9UNW9, A6ZKR5, A7TT46, B3LNH0, C5DIR2, C5E0I9, C7GND0, C8Z3W4, P38199, Q6CNI6, Q6FUD8, Q756R8, O42254, O57526, O73932, O75179, O88477

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2225 predictions. Top by Δscore:

Variant	Effect	Δscore
3:51958783:CGCT:C	donor_loss	1.0000
3:51958784:GCTCA:G	donor_loss	1.0000
3:51958785:CT:C	donor_loss	1.0000
3:51958786:TCACC:T	donor_loss	1.0000
3:51958787:CA:C	donor_loss	1.0000
3:51958788:A:AC	donor_gain	1.0000
3:51958788:A:C	donor_loss	1.0000
3:51958789:C:CC	donor_gain	1.0000
3:51958789:CCAGG:C	donor_gain	1.0000
3:51958955:ATCAA:A	acceptor_gain	1.0000
3:51958956:TCAA:T	acceptor_gain	1.0000
3:51958957:CAA:C	acceptor_gain	1.0000
3:51958957:CAAC:C	acceptor_gain	1.0000
3:51958958:A:T	acceptor_gain	1.0000
3:51958958:AA:A	acceptor_gain	1.0000
3:51958959:AC:A	acceptor_loss	1.0000
3:51958960:C:CA	acceptor_loss	1.0000
3:51958960:C:CC	acceptor_gain	1.0000
3:51959041:GCTCA:G	donor_loss	1.0000
3:51959042:CTCA:C	donor_loss	1.0000
3:51959043:TCAC:T	donor_loss	1.0000
3:51959044:CA:C	donor_loss	1.0000
3:51959045:A:AC	donor_gain	1.0000
3:51959045:A:C	donor_loss	1.0000
3:51959046:C:CC	donor_gain	1.0000
3:51959046:CATCG:C	donor_gain	1.0000
3:51959095:CAGTC:C	acceptor_gain	1.0000
3:51959097:GTC:G	acceptor_gain	1.0000
3:51959098:TC:T	acceptor_gain	1.0000
3:51959099:CC:C	acceptor_gain	1.0000

AlphaMissense

2567 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:51958802:A:G	L304P	1.000
3:51958811:G:T	A301D	1.000
3:51958836:C:G	G293R	1.000
3:51958841:A:T	I291N	1.000
3:51958847:A:T	V289D	1.000
3:51958889:A:C	I275S	1.000
3:51958889:A:G	I275T	1.000
3:51958889:A:T	I275N	1.000
3:51958910:C:G	R268P	1.000
3:51958913:A:C	I267S	1.000
3:51958922:A:C	I264S	1.000
3:51958922:A:G	I264T	1.000
3:51958922:A:T	I264N	1.000
3:51958931:C:T	G261D	1.000
3:51958940:C:A	G258V	1.000
3:51958940:C:T	G258E	1.000
3:51958943:A:T	I257N	1.000
3:51958952:C:T	G254D	1.000
3:51959057:A:T	V248D	1.000
3:51959624:A:C	Y182D	1.000
3:51959925:A:C	C162W	1.000
3:51959926:C:T	C162Y	1.000
3:51959927:A:G	C162R	1.000
3:51959950:C:A	G154V	1.000
3:51959950:C:T	G154E	1.000
3:51959951:C:A	G154W	1.000
3:51959951:C:G	G154R	1.000
3:51959951:C:T	G154R	1.000
3:51959956:A:T	V152E	1.000
3:51959962:A:T	V150D	1.000

dbSNP variants (sampled 300 via entrez): RS1000387144 (3:51962201 T>C), RS1000596514 (3:51966673 C>T), RS1000651797 (3:51957116 G>A,T), RS1000663011 (3:51959748 G>A), RS1000814477 (3:51963546 A>T), RS1000883490 (3:51961888 G>A,T), RS1000931956 (3:51966408 G>C,T), RS1001118988 (3:51963914 CT>C), RS1001217335 (3:51957657 G>T), RS1001224577 (3:51962657 C>T), RS1001359207 (3:51969037 G>A), RS1001369210 (3:51968676 C>G), RS1001483241 (3:51963280 G>A), RS1001716686 (3:51962348 C>G), RS1002056785 (3:51957968 G>C)

Disease associations

OMIM: gene MIM:608503 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, increases expression	3
Cyclosporine	increases expression, decreases expression	3
Air Pollutants	increases expression, decreases expression, affects cotreatment, increases abundance	2
Benzo(a)pyrene	decreases methylation, increases expression, increases methylation	2
Valproic Acid	increases methylation, affects expression, decreases expression	2
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects cotreatment, decreases methylation	1
bromoacetate	decreases expression	1
sulforaphane	decreases expression	1
delphinidin	affects expression	1
potassium chromate(VI)	decreases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression, increases expression	1
dorsomorphin	decreases expression, increases expression, affects cotreatment	1
SRT2183	increases expression	1
jinfukang	affects cotreatment, increases expression	1
brevetoxin 2	increases expression	1
MT19c compound	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Cisplatin	affects cotreatment, increases expression	1
Diazinon	increases methylation	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects cotreatment, increases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.